Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency

A new case of 3-hydroxyacyl-CoA dehydrogenase deficiency is described with a relatively benign course

Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT

Measurement of tt‾\mathrm {t}\overline{\mathrm {t}} t t ¯ production with additional jet activity, including b\mathrm {b} b quark jets, in the dilepton decay channel using pp collisions at s=8 TeV\sqrt{s} = 8\,\text {TeV} s = 8 TeV

Jet multiplicity distributions in top quark pair ( ${{\rm t}}{\rm {\overline{t}}}$ ) events are measured in pp collisions at a centre-of-mass energy of 8 TeV with the CMS detector at the LHC using a data set corresponding to an integrated luminosity of 19.7 $\,\text {fb}^\text {-1}$ . The measurement is performed in the dilepton decay channels ( $\mathrm {e}^+\mathrm {e}^-$ , $\mathrm {\mu ^+}\mathrm {\mu ^-}$ , and $\mathrm {e}^{\pm }\mathrm {\mu }^{\mp }$ ). The absolute and normalized differential cross sections for $\mathrm {t}\overline{\mathrm {t}}$ production are measured as a function of the jet multiplicity in the event for different jet transverse momentum thresholds and the kinematic properties of the leading additional jets. The differential $\mathrm {\mathrm {t} \overline{\mathrm {t}} \mathrm {b}}$ and $\mathrm {\mathrm {t} \overline{\mathrm {t}} \mathrm {b} \overline{\mathrm {b}}}$ cross sections are presented for the first time as a function of the kinematic properties of the leading additional $\mathrm {b}$ jets. Furthermore, the fraction of events without additional jets above a threshold is measured as a function of the transverse momenta of the leading additional jets and the scalar sum of the transverse momenta of all additional jets. The data are compared and found to be consistent with predictions from several perturbative quantum chromodynamics event generators and a next-to-leading order calculation

A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP

Parkinson’s disease (PD) is a neurodegenerative disorder frequent at old age characterized by atrophy of the nigrostriatal projection. Overexpression and A53T-mutation of the presynaptic, vesicle-associated chaperone alpha-synuclein are known to cause early-onset autosomal dominant PD. We previously generated mice with transgenic overexpression of human A53T-alpha-synuclein (A53T-SNCA) in dopaminergic substantia nigra neurons as a model of early PD. To elucidate the early and late effects of A53T-alpha-synuclein on the proteome of dopaminergic nerve terminals in the striatum, we now investigated expression profiles of young and old mice using two-dimensional fluorescence difference in gel electrophoresis (2D-DIGE) and mass spectrometry. In total, 15 proteins were upregulated and 2 downregulated. Mice before the onset of motor anomalies showed an upregulation of the spot containing 14-3-3 proteins, in particular the epsilon isoform, as well as altered levels of chaperones, vesicle trafficking and bioenergetics proteins. In old mice, the persistent upregulation of 14-3-3 proteins was aggravated by an increase of glial fibrillary acidic protein (GFAP) suggesting astrogliosis due to initial neurodegeneration. Independent immunoblots corroborated GFAP upregulation and 14-3-3 upregulation for the epsilon isoform, and also detected significant eta and gamma changes. Only for 14-3-3 epsilon a corresponding mRNA increase was observed in midbrain, suggesting it is transcribed in dopaminergic perikarya and accumulates as protein in presynapses, together with A53T-SNCA. 14-3-3 proteins associate with alpha-synuclein in vitro and in pathognomonic Lewy bodies of PD brains. They act as chaperones in signaling, dopamine synthesis and stress response. Thus, their early dysregulation probably reflects a response to alpha-synuclein toxicity

A search for new phenomena in pp collisions at root s=13TeV in final states with missing transverse momentum and at least one jet using the alpha(T) variable

Peer reviewe

Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV

Properties of the Higgs boson with mass near 125$$, ext GeV$$GeV are measured in proton-proton collisions with the CMS experiment at the LHC. Comprehensive sets of production and decay measurements are combined. The decay channels include γγ, ZZ, WW, ττ, bb, and μμ pairs. The data samples were collected in 2011 and 2012 and correspond to integrated luminosities of up to 5.1fb-1at 7TeV and up to 19.7fb-1at 8 TeV. From the high-resolution γγ and ZZ channels, the mass of the Higgs boson is determined to be (Formula presented). For this mass value, the event yields obtained in the different analyses tagging specific decay channels and production mechanisms are consistent with those expected for the standard model Higgs boson. The combined best-fit signal relative to the standard model expectation is (Formula presented) at the measured mass. The couplings of the Higgs boson are probed for deviations in magnitude from the standard model predictions in multiple ways, including searches for invisible and undetected decays. No significant deviations are found