Suffering in ancient worldview: a comparative study of Acts, Fourth Maccabees, and Seneca

This thesis analyzes how suffering functions in the worldviews of the Roman Stoic Seneca, the Jewish author of 4 Maccabees, and the Christian historian Luke. Acts 17:17–18 invites such a comparison by presenting Paul’s Christian missionary activity in direct engagement with Hellenistic Judaism and popular Greco-Roman philosophy, including Stoicism. Chapters 1, 3, and 5 offer close readings of representative texts from Acts, 4 Maccabees, and Seneca’s essays and letters with a view to highlighting the authors’ treatments of suffering. Chapters 2, 4, and 6 utilize heuristic worldview questions to clarify and synthesize how each writer accounts for suffering, vis-à-vis their perspectives on God, humanity, the world’s problem and its solution, and the future. Chapter 7 presents an ancient conversation between these three authors modeled after Cicero’s De Natura Deorum. This thesis makes at least three significant contributions to scholarship. First, this is the only extended comparison of Seneca, Luke, and 4 Maccabees. The value and importance of studying early Christianity alongside Stoicism and Hellenistic Judaism is well known, but previous studies have focused on Paul, not Luke, who is typically compared with Josephus, not 4 Maccabees. Second, building on N. T. Wright’s work, this study demonstrates that worldview questions offer a fruitful method for comparing different authors and groups. This study does not attempt to prove literary or intellectual dependence but to compare these authors at the worldview level. Third, this thesis contributes to the important and often neglected theme of suffering in Luke-Acts, 4 Maccabees, and Seneca’s writings. This is the first systematic treatment of suffering in Seneca’s thought and in 4 Maccabees. This study builds on Cunningham’s and Mittelstadt’s recent monographs on suffering in Luke- Acts and advances the discussion by offering clear definitions of suffering and persecution, illustrated by first-century examples, and by an extended worldview comparison of Luke with other authors. In Luke-Acts, God is not “outside suffering” as Seneca argues but acts through the suffering of Jesus and his followers to set the world of sin and suffering right again, in fulfillment of his ancient promises

Northern Steamship Company: The depreciation problem in the nineteenth century

In 1889 a New Zealand company had to write down its paid-up capital by 27 percent, because, the Chairman stated, previous management had failed to allow for depreciation as an expense. An investigation was conducted to see if this capital reduction could have been avoided had the company followed modern depreciation policy. This revealed that the failure to depreciate adequately was not the main cause of the capital reduction, other firms followed the same practice and contemporary English legislation did not permit depreciation as a tax deductible item, while United States courts were rejecting depreciation as a valid expense

Targeted online liquid chromatography electron capture dissociation mass spectrometry for the localization of sites of in vivo phosphorylation in human Sprouty2

We demonstrate a strategy employing collision-induced dissociation for phosphopeptide discovery, followed by targeted electron capture dissociation (ECD) for site localization. The high mass accuracy and low background noise of the ECD mass spectra allow facile sequencing of coeluting isobaric phosphopeptides, with up to two isobaric phosphopeptides sequenced from a single mass spectrum. In contrast to the previously described neutral loss of dependent ECD method, targeted ECD allows analysis of both phosphotyrosine peptides and lower abundance phosphopeptides. The approach was applied to phosphorylation analysis of human Sprouty2, a regulator of receptor tyrosine kinase signaling. Fifteen sites of phosphorylation were identified, 11 of which are novel

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum

Minería de datos para el descubrimiento de patrones en enfermedades respiratorias en Bogotá, Colombia

Trabajo de InvestigaciónEl presente proyecto se basa en la aplicación de minería de datos mediante el algoritmo de clustering K- means que permita la generación de un modelo descriptivo con el análisis de los datos y con el objetivo de identificar posibles comportamientos en enfermedades respiratorias en la ciudad de Bogotá. El conjunto de clústeres generados por la herramienta RapidMiner es la recopilación de datos de un periodo de cinco años de 2012 a 2016, en donde se contemplan el número de casos asociados a 184 diagnósticos de enfermedades respiratorias y la edad de los pacientes corresponde de 0 a 5 años.Trabajo de Investigación1. GENERALIDADES 2. OBJETIVOS 3. JUSTIFICACIÓN 4. DELIMITACIÓN 5. MARCO REFERENCIAL 6. METODOLOGÍA 7. FUENTES DE EXTRACCIÓN Y SUS VARIABLES 8. DISEÑO 9. SELECCIÓN DE ALGORITMOS DE CLUSTERING 10. RECONOCER PATRONES A PARTIR DE LA INFORMACIÓN RECOPILADA 11. CONCLUSIONES 12. TRABAJOS FUTUROS 13. REFERENCIAS BIBLIOGRÁFICAS 14. ANEXOSPregradoIngeniero de Sistema

Current challenges in software solutions for mass spectrometry-based quantitative proteomics

This work was in part supported by the PRIME-XS project, grant agreement number 262067, funded by the European Union seventh Framework Programme; The Netherlands Proteomics Centre, embedded in The Netherlands Genomics Initiative; The Netherlands Bioinformatics Centre; and the Centre for Biomedical Genetics (to S.C., B.B. and A.J.R.H); by NIH grants NCRR RR001614 and RR019934 (to the UCSF Mass Spectrometry Facility, director: A.L. Burlingame, P.B.); and by grants from the MRC, CR-UK, BBSRC and Barts and the London Charity (to P.C.