Phenomenological Lambda-Nuclear Interactions

Variational Monte Carlo calculations for ${_{\Lambda}^4}H$ (ground and excited states) and ${_{\Lambda}^5}He$ are performed to decipher information on ${\Lambda}$-nuclear interactions. Appropriate operatorial nuclear and ${\Lambda}$-nuclear correlations have been incorporated to minimize the expectation values of the energies. We use the Argonne $\upsilon_{18}$ two-body NN along with the Urbana IX three-body NNN interactions. The study demonstrates that a large part of the splitting energy in ${_{\Lambda}^4}H$ ($0^+-1^+$) is due to the three-body ${\Lambda}$ NN forces. $_{\Lambda}^{17}O$ hypernucleus is analyzed using the {\it s}-shell results. $\Lambda$ binding to nuclear matter is calculated within the variational framework using the Fermi-Hypernetted-Chain technique. There is a need to correctly incorporate the three-body ${\Lambda}$ NN correlations for $\Lambda$ binding to nuclear matter.Comment: 18 pages (TeX), 2 figure

Impact of gamma-ray irradiation on dynamic characteristics of Si and SiC power MOSFETs

Power electronic devices in spacecraft and military applications requires high radiation tolerant. The semiconductor devices face the issue of device degradation due to their sensitivity to radiation. Power MOSFET is one of the primary components of these power electronic devices because of its capabilities of fast switching speed and low power consumption. These abilities are challenged by ionizing radiation which damages the devices by inducing charge built-up in the sensitive oxide layer of power MOSFET. Radiations degrade the oxides in a power MOSFET through Total Ionization Dose effect mechanism that creates defects by generation of excessive electron–hole pairs causing electrical characteristics shifts. This study investigates the impact of gamma ray irradiation on dynamic characteristics of silicon and silicon carbide power MOSFET. The switching speed is limit at the higher doses due to the increase capacitance in power MOSFETs. Thus, the power circuit may operate improper due to the switching speed has changed by increasing or decreasing capacitances in power MOSFETs. These defects are obtained due to the penetration of Cobalt60 gamma ray dose level from 50krad to 600krad. The irradiated devices were evaluated through its shifts in the capacitance-voltage characteristics, results were analyzed and plotted for the both silicon and silicon carbide power MOSFET

Microcontroller Implementation Of Single Phase Inverter Switching Strategies.

This paper presents the practical microcontroller implementation of single phase inverter switching strategies

Compacton existence and spin-orbit density dependence in Bose-Einstein condensates

We demonstrate the existence of compactons matter waves in binary mixtures of Bose-Einstein condensates (BEC) trapped in deep optical lattices (OL) subjected to equal contributions of intra-species Rashba and Dresselhaus spin-orbit coupling (SOC) under periodic time modulations of the intra-species scattering length. We show that these modulations lead to the rescaling of the SOC parameters that involve the density imbalance of the two components. This gives rise to a density-dependent SOC parameters strongly influence the existence and stability of compacton matter waves. The stability of SOC-compactons is investigated both by linear stability analysis and by time integrations of the coupled Gross-Pitaevskii equations. We find that SOC restricts the parameter ranges for stable stationary SOC-compacton existence but, on the other side, it gives a more stringent signature of their occurrence. In particular, SOC-compactons should appear when the intra-species interactions and the number of atoms in the two components are perfectly balanced (or close to being balanced for metastable cases). The possibility to use SOC-compactons as a tool for indirect measurements of the number of atoms and/or the intra-species interactions, is also suggested.Comment: 14 pages, 11 figure

Prevalence of PALB2 Mutations in Breast Cancer Patients in Multi-Ethnic Asian Population in Malaysia and Singapore

10.1371/journal.pone.0073638PLoS ONE88-POLN

High-throughput screening of perovskite alloys for piezoelectric performance and thermodynamic stability

We screen a large chemical space of perovskite alloys for systems with optimal properties to accommodate a morphotropic phase boundary (MPB) in their composition-temperature phase diagram, a crucial feature for high piezoelectric performance. We start from alloy end points previously identified in a high-throughput computational search. An interpolation scheme is used to estimate the relative energies between different perovskite distortions for alloy compositions with a minimum of computational effort. Suggested alloys are further screened for thermodynamic stability. The screening identifies alloy systems already known to host an MPB and suggests a few others that may be promising candidates for future experiments. Our method of investigation may be extended to other perovskite systems, e.g., (oxy-)nitrides, and provides a useful methodology for any application of high-throughput screening of isovalent alloy systems

Effective Sampling-Based Assessment Method for Evaluating Electrical Engineering Programme Performance

Challenges in the conventional way of measuring programme outcome include large data sets to be processed, a large amount of manpower, operating cost increment and time consuming. A sampling-based approach to evaluate the performance of a programme is proposed and a mathematical model is developed to determine the overall programme outcome score. The criteria for course selection and percentage of students considered in the assessment, was designed to accelerate the process. The results obtained from the implementation of sampling based approach in the assessment have shown that the programme is successful and the students have achieved the required knowledge and skills. The sampling-based approach is capable of demonstrating the programme and the students’ achievement

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

Introduction: Tumor lymphocyte infiltration is associated with clinical response to chemotherapy in estrogen receptor (ER) negative breast cancer. To identify variants in immunosuppressive pathway genes associated with prognosis after adjuvant chemotherapy for ER-negative patients, we studied stage I-III invasive breast cancer patients of European ancestry, including 9,334 ER-positive (3,151 treated with chemotherapy) and 2,334 ER-negative patients (1,499 treated with chemotherapy). Methods: We pooled data from sixteen studies from the Breast Cancer Association Consortium (BCAC), and employed two independent studies for replications. Overall 3,610 single nucleotide polymorphisms (SNPs) in 133 genes were genotyped as part of the Collaborative Oncological Gene-environment Study, in which phenotype and clinical data were collected and harmonized. Multivariable Cox proportional hazard regression was used to assess genetic associations with overall survival (OS) and breast

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk