Mutations in the Mitochondrial Methionyl-tRNA Synthetase Cause a Neurodegenerative Phenotype in Flies and a Recessive Ataxia (ARSAL) in Humans

The study of Drosophila neurodegenerative mutants combined with genetic and biochemical analyses lead to the identification of multiple complex mutations in 60 patients with a novel form of ataxia/leukoencephalopathy

A semi-automated cleaning system for indoor floor and air quality control

Abstract Researchers have found through different tests, that all kinds of harmful substances are present in case of an indoor environment, such as heavy metals, pesticides - these come from household products, toys, carbon dioxide, humidity, etc. People are regularly exposed to these harmful substances through breathing and skin contact. This long-term exposure can affect people’s health very seriously. To achieve a good quality environment indoors, a portable device is proposed here. Through, the development of this device we can monitor indoor air quality, control the indoor air quality and also clean the floor. Monitoring is done by sensors; controlling is performed by a mini air purifier which is attached to a floor cleaner. Whenever the parameters which are received from the sensors are more than the permittable limit then the air purifier starts its operation and stops when the parameters are within the permittable limit, by this process we can reduce the power consumption of the device. The whole device is driven by a battery that can be rechargeable.</jats:p

A Methodology for Evaluating Delay and Power on Binary Counters and Block Level Optimization

Abstract: In this paper, slice level optimization is performed on the conventional 6:3 counter and then finally integrated all the slices to the original one. Slice level optimization corresponds to partition the given circuit in to number of blocks such that final integration can be done effectively. Considering individual blocks Power testing and delay testing, results were taken by triggering the activities which lead to power consumption and all possible critical paths were also tested for every individual block and then comparison is made. Test vectors are also applied such that every consecutive cycle output is complemented, so that low to high and high to low delays can be captured with in a smaller number of test vectors. Identical strategy is applied to measure the power because for every two cycles only one power consuming event occurs on a single node under consideration. The proposed 6:3 counter is 36% faster than the conventional one and also saves the power for about 56%. Utilizing more NAND, NOR and AOI gates instead of AND, OR gates have led to the achieved optimization. Keywords: Counter, Delay Testing, Power Testing, Slice level Optimization, Test Vectors</jats:p

Biosynthetic modulation of carbon-doped ZnO for rapid photocatalytic endocrine disruptive remediation and hydrogen evolution

Pharmaceuticals and industry effluents such as dyes, and organic contaminants in wastewater are being identified among the top endocrine disruptive compounds with inherent recalcitrant and hazardous effects. Herein, microwave-induced coconut shell-activated carbon-doped-zinc-oxide (CSAC-ZnO) nanocomposites at various calcined temperatures were synthesized by hydrothermal techniques, characterized and applied towards photocatalytic degradation of endocrine disruptive compounds (EDC) and green energy generation via photocatalytic hydrogen production. The surface area, structural crystallinity, optical properties, thermal stability, functional group and morphological properties were accessed via Powdered X-ray diffraction, UV-Diffuse Reflectance Spectroscopy, Fourier Transform Infrared, Thermal Gravimetric Analysis, Brunauer-Emmett-Teller, X-ray Photoelectron Spectroscopy, Scanning Electron Microscopy, and Transmission Electron Microscopy. An extremely high surface area of 320.65 m2g-1 was observed from the as-prepared carbon decorated (CSAC-ZnO) and excellent light absorption was shown by all the photocatalysts. The exceptional photo-degradation efficiencies of CSAC-ZnO on methylene blue (MB) cationic dye as well as ibuprofen (IBP) pharmaceutical are reported. Very rapid 91% MB and 94% IBP pharmaceutical degradation efficiency obtained within 60 min and 30 min, respectively were observed. The kinetics of the photocatalytic activities at different pH followed pseudo-first-order kinetics. The Liquid Chromatography-Mass Spectrometry analysis on MB and IBP before and after photodegradation confirmed the formation of intermediate products. The modulated CSAC-ZnO@600 exhibits hydrogen production of 18947μmolg−1h−1. The photocatalysts showed current densities ranging from 0.03 to 0.05 mA/cm2. The Fast charge transfer is supported by electrochemical impedance spectroscopy and −0.3 and −0.49 V versus Ag/AgCl flat band potentials. The relation between the electronic and catalytic properties is revealed from the calculation of density functional theory (DFT). The study revealed the impact of calcination on the properties of the biomass carbon-doped-photocatalysts, excellent photocatalytic degradation efficiency and efficient hydrogen production from water-splitting giving relevance to biomass carbon-doped CSAC-ZnO in environmental remediation and green energy production