Shape memory alloy based smart landing gear for an airship

The design and development of a shape memory alloy based smart landing gear for aerospace vehicles is based on a13; novel design approach. The smart landing gear comprises a landing beam, an arch, and a superelastic nickeltitanium shape memory alloy element. This design is of a generic nature and is applicable to a certain class of light13; aerospace vehicles. In this paper a specixFB01;c case of the shape memory alloy based smart landing gear design and13; development applicable to a radio controlled semirigid airship (radio controlled blimp) of 320 m3 volume is13; presented.Ajudicious combination of carbon xFB01;ber reinforced plastic for the landing beam, cane (naturally occurring13; plant product) wrapped with carbon xFB01;ber reinforced plastic for the arch, and superelastic shape memory alloy is13; used in the development. An appropriate sizing of the arch and landing beam is arrived at to meet the dual requirement of low weight and high-energy dissipation while ndergoing x201C;large elasticx201D; (large nonlinear recoverable13; elastic strain) deformations to ensure soft landings when the airship impacts the ground. The soft landing is required13; to ensure that shock and vibration are minimized (to protect the sensitive payload). The inherently large energydissipating character of the superelastic shape memory alloy element in the tensile mode of deformation and the superior elastic bounce back features of the landing gear provide the ideal solution.Anonlinear analysis based on the classical and xFB01;nite element method approach is followed to analyze the structure. Necessary experiments and tests have been conducted to check the veracity of the design. Good correlation has been found between the analyses and testing. This exercise is intended to provide an alternate method of developing an efxFB01;cient landing gear with satisfactory geometry for a x201C;certain class of light aerospace vehiclesx201D; such as airships, rotorcraft, and other light unmanned air vehicles

Parameter estimation with Bayesian estimation applied to multiple species in the presence of biases and correlations

The original formulation of Bayesian estimation applied to multiple species (BEAMS) showed how to use a data set contaminated by points of multiple underlying types to perform unbiased parameter estimation. An example is cosmological parameter estimation from a photometric supernova sample contaminated by unknown Type Ibc and II supernovae. Where other methods require data cuts to increase purity, BEAMS uses all of the data points in conjunction with their probabilities of being each type. Here we extend the BEAMS formalism to allow for correlations between the data and the type probabilities of the objects as can occur in realistic cases. We show with simple simulations that this extension can be crucial, providing a 50 per cent reduction in parameter estimation variance when such correlations do exist. We then go on to perform tests to quantify the importance of the type probabilities, one of which illustrates the effect of biasing the probabilities in various ways. Finally, a general presentation of the selection bias problem is given, and discussed in the context of future photometric supernova surveys and BEAMS, which lead to specific recommendations for future supernova survey

Statistical classification techniques for photometric supernova typing

Future photometric supernova surveys will produce vastly more candidates than can be followed up spectroscopically, highlighting the need for effective classification methods based on light curves alone. Here we introduce boosting and kernel density estimation techniques which have minimal astrophysical input, and compare their performance on 20 000 simulated Dark Energy Survey light curves. We demonstrate that these methods perform very well provided a representative sample of the full population is used for training. Interestingly, we find that they do not require the redshift of the host galaxy or candidate supernova. However, training on the types of spectroscopic subsamples currently produced by supernova surveys leads to poor performance due to the resulting bias in training, and we recommend that special attention be given to the creation of representative training samples. We show that given a typical non-representative training sample, S, one can expect to pull out a representative subsample of about 10 per cent of the size of S, which is large enough to outperform the methods trained on all of

Statistical Classification Techniques for Photometric Supernova Typing

Future photometric supernova surveys will produce vastly more candidates than can be followed up spectroscopically, highlighting the need for effective classification methods based on lightcurves alone. Here we introduce boosting and kernel density estimation techniques which have minimal astrophysical input, and compare their performance on 20,000 simulated Dark Energy Survey lightcurves. We demonstrate that these methods are comparable to the best template fitting methods currently used, and in particular do not require the redshift of the host galaxy or candidate. However both methods require a training sample that is representative of the full population, so typical spectroscopic supernova subsamples will lead to poor performance. To enable the full potential of such blind methods, we recommend that representative training samples should be used and so specific attention should be given to their creation in the design phase of future photometric surveys.Comment: 19 pages, 41 figures. No changes. Additional material and summary video available at http://cosmoaims.wordpress.com/2010/09/30/boosting-for-supernova-classification

The variability of sagittal spino-pelvic mobility in Indian population

Background: Abnormal spino-pelvic mobility is increasingly recognized as a leading cause for hip instability following arthroplasty.Methods: We studied the lateral spino-pelvic radiographs of 90 patients, with no spine/hip pathology in standing and sitting positions. We measured the change in sacral slope and grouped them into three spino-pelvic patterns.Results: We found that 50% of study subjects had normal spino-pelvic mobility. The remaining 50% were either hypermobile (24%) or stiff (26%). The stiff spines were either fixed (11%) or hypomobile (15%).Conclusions: Our study shows that in a normal population without any prior hip/spine pathology a significant percentage (50%) have abnormal spino-pelvic mobility. The significance of spinal stiffness in younger age group need to be looked further to make any changes in acetabular cup placement during hip replacement

Gaucher disease: A cause of massive splenomegaly in a 15-year-old black African male

Patients with Gaucher disease (GD), a rare autosomal recessive lysosomal storage disease, commonly present to paediatricians with massive splenomegaly. While the diagnosis and management of patients with this chronic multisystem disorder has evolved significantly in recent years, the initial diagnosis represents a challenge. We describe the case of a 15-year-old black African male who presented with abdominal distension, delayed growth and fatigue. Initial laboratory studies revealed severe anaemia (haemoglobin concentration 8 g/dL) and moderate thrombocytopenia (platelet count 80 × 109/L). A computed tomography scan of the abdomen showed an enlarged liver of 173 mm and massive splenomegaly of 27 mm. The diagnosis of GD was confirmed by reduced beta-glucocerebrosidase activity and heterozygous mutations in the GBA1 gene. The patient was managed at a dedicated paediatric haematology unit with enzyme replacement therapy and regular clinical, biochemical and radiological monitoring

Global, regional, and national burden of chronic kidney disease, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods The main data sources we used were published literature, vital registration systems, end-stage kidney disease registries, and household surveys. Estimates of CKD burden were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool, and included incidence, prevalence, years lived with disability, mortality, years of life lost, and disability-adjusted life-years (DALYs). A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. Findings Globally, in 2017, 1·2 million (95% uncertainty interval [UI] 1·2 to 1·3) people died from CKD. The global all-age mortality rate from CKD increased 41·5% (95% UI 35·2 to 46·5) between 1990 and 2017, although there was no significant change in the age-standardised mortality rate (2·8%, −1·5 to 6·3). In 2017, 697·5 million (95% UI 649·2 to 752·0) cases of all-stage CKD were recorded, for a global prevalence of 9·1% (8·5 to 9·8). The global all-age prevalence of CKD increased 29·3% (95% UI 26·4 to 32·6) since 1990, whereas the age-standardised prevalence remained stable (1·2%, −1·1 to 3·5). CKD resulted in 35·8 million (95% UI 33·7 to 38·0) DALYs in 2017, with diabetic nephropathy accounting for almost a third of DALYs. Most of the burden of CKD was concentrated in the three lowest quintiles of Socio-demographic Index (SDI). In several regions, particularly Oceania, sub-Saharan Africa, and Latin America, the burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected. 1·4 million (95% UI 1·2 to 1·6) cardiovascular disease-related deaths and 25·3 million (22·2 to 28·9) cardiovascular disease DALYs were attributable to impaired kidney function. Interpretation Kidney disease has a major effect on global health, both as a direct cause of global morbidity and mortality and as an important risk factor for cardiovascular disease. CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle SDI

The changing global distribution and prevalence of canine transmissible venereal tumour.

BACKGROUND: The canine transmissible venereal tumour (CTVT) is a contagious cancer that is naturally transmitted between dogs by the allogeneic transfer of living cancer cells during coitus. CTVT first arose several thousand years ago and has been reported in dog populations worldwide; however, its precise distribution patterns and prevalence remain unclear. RESULTS: We analysed historical literature and obtained CTVT prevalence information from 645 veterinarians and animal health workers in 109 countries in order to estimate CTVT's former and current global distribution and prevalence. This analysis confirmed that CTVT is endemic in at least 90 countries worldwide across all inhabited continents. CTVT is estimated to be present at a prevalence of one percent or more in dogs in at least 13 countries in South and Central America as well as in at least 11 countries in Africa and 8 countries in Asia. In the United States and Australia, CTVT was reported to be endemic only in remote indigenous communities. Comparison of current and historical reports of CTVT indicated that its prevalence has declined in Northern Europe, possibly due to changes in dog control laws during the nineteenth and twentieth centuries. Analysis of factors influencing CTVT prevalence showed that presence of free-roaming dogs was associated with increased CTVT prevalence, while dog spaying and neutering were associated with reduced CTVT prevalence. Our analysis indicated no gender bias for CTVT and we found no evidence that animals with CTVT frequently harbour concurrent infectious diseases. Vincristine was widely reported to be the most effective therapy for CTVT. CONCLUSIONS: Our results provide a survey of the current global distribution of CTVT, confirming that CTVT is endemic in at least 90 countries worldwide. Additionally, our analysis highlights factors that continue to modify CTVT's prevalence around the world and implicates free-roaming dogs as a reservoir for the disease. Our analysis also documents the disappearance of the disease from the United Kingdom during the twentieth century, which appears to have been an unintentional result of the introduction of dog control policies.This is the author's accepted manuscript. The final version of this article has been published by BioMed Central: http://www.biomedcentral.com/1746-6148/10/168

Magnetic and transport properties of Mo substituted La0.67Ba0.33Mn1-xMoxO3 perovskite system

The effect of doping Mo for Mn on the magnetic and transport properties of the colossal magnetoresistance material, La0.67Ba0.33MnO3, has been studied. Compounds of the series La0.67Ba0.33Mn1-xMoxO3 (x=0.0 to 0.1) have been prepared and found to crystallize in the orthorhombic structure (space group Pbnm). Energy Dispersive X-ray Analysis (EDAX) measurements confirm the stoichiometry of all the samples. Magnetotransport and magnetization measurements reveal that the metal-insulator transition temperature (Tp) decreases from 330K for x=0 to 255K for x=0.1. The change in Tp on Mo substitution is relatively much smaller than the corresponding change observed on substitution by other transition elements, such as Ti, Fe, Co, Ni, etc. Further, the ferromagnetic transition temperature (TC) is nearly unchanged by Mo substitution. This is in striking contrast to the large decrease in TC observed with substitution of above-mentioned 3d elements. These unusual magnetic and transport properties of La0.67Ba0.33Mn1-xMoxO3 may be either due to the formation of magnetic pair between Mn and Mo or due to strong Mo(4d)-O(2p) overlap, which in turn, may affect the Mn-Mn interaction via the oxygen atomsComment: 25 pages, 5 figure