Probing the massive star forming environment - a multiwavelength investigation of the filamentary IRDC G333.73+0.37

We present a multiwavelength study of the filamentary infrared dark cloud (IRDC) G333.73+0.37. The region contains two distinct mid-infrared sources S1 and S2 connected by dark lanes of gas and dust. Cold dust emission from the IRDC is detected at seven wavelength bands and we have identified 10 high density clumps in the region. The physical properties of the clumps such as temperature: 14.3-22.3 K and mass: 87-1530 M_sun are determined by fitting a modified blackbody to the spectral energy distribution of each clump between 160 micron and 1.2 mm. The total mass of the IRDC is estimated to be $~4700 M_sun. The molecular line emission towards S1 reveals signatures of protostellar activity. Low frequency radio emission at 1300 and 610 MHz is detected towards S1 (shell-like) and S2 (compact morphology), confirming the presence of newly formed massive stars in the IRDC. Photometric analysis of near and mid-infrared point sources unveil the young stellar object population associated with the cloud. Fragmentation analysis indicates that the filament is supercritical. We observe a velocity gradient along the filament, that is likely to be associated with accretion flows within the filament rather than rotation. Based on various age estimates obtained for objects in different evolutionary stages, we attempt to set a limit to the current age of this cloud.Comment: 26 pages, 20 figures, accepted by Ap

Effect of ethanolic extract of the leaves of plant Annona squamosa on hematological and biochemical parameters in normal rats

The present study was designed to elucidate the effects of ethanolic extract of leaves of Annona squamosa L. (Annonaceae) on hematological and biochemical indices in normal rat. The male rats were gavaged ethanolic extract of Annona squamosa leaves at the dose level of 200 and 300 mg/Kg body weight/rat/day for 28 days. A significant decrease in hematological indices like hemoglobin, RBC count and increase in WBC count, serum parameter like serum cholesterol, serum GPT and GOT was observed

Biological utilities of Parthenium hysterophorus

Parthenium hysterophorus L. (Asteraceae) is a serious weed of pastures, wasteland and agricultural fields in world. Various problems are posed by the weed to human health, agriculture, live stock production and biodiversity. It is used as folk remedy against various afflictions. The review discusses several prominent biological utilities of P. hysterophorus as it contains several important chemical constituents mainly histamine, saponin, glucosides and triterpene (sesquiterpene) and can be of use for the purpose of biocontrol of various pathogens , for its medicinal utility and even for the purpose of food

Estimation of C II and C II* column densities along Galactic sight-lines

We present interstellar C II (1334.5323 \AA) and C II* (1335.7077 \AA) column density measurements along 14 Galactic sight-lines. These sight-lines sample a variety of Galactic disk environments and include paths that range nearly two orders of magnitude in average hydrogen densities () along the lines of sight. Five of the sight-lines show super-Solar gas phase abundances of carbon. Our results show that the excess carbon along these sight-lines may result from different mechanisms taking place in the regions associated with these stars.Comment: 9 pages, 3 figures; Accepted for publication in BAS

Dynamics of inter-district developmental disparities in Haryana

The present study deals with the development disparities in districts of Haryana according to their level of development. The study utilized data over three points of time, viz. 1991-92, 2001-02, and 2011-12. Assessment of development in agricultural, industrial, infrastructural and socio-economic sectors has been studied using composite indices based on forty indicators. Out of the forty indicators, 19 were directly concerned with agricultural development, 4, 8 and 9 respectively reflected the progress of development in industrial, infrastructural, and socio-economic sectors. Sector-wise indices were combined to obtain weighted index for the overall development. The study indicated wide disparities in level of development among districts of Haryana in all the periods of study.The district of Mahendragarh lagged behind in almost all the sectors considered for this study. The districts of Faridabad and Gurgaon lagged behind in agriculture while the district of Karnal excelled in agriculture in all the three periods. The districts of Ambala, Faridabad and Gurgaon ranked first in overall development in 1991-92, 2001-02 and 2011-12, respectively, whereas Mahendragarh ranked last in 1991-92 and 2001-02 and the newly formed district Mewat in 2011-12. Spearman’s rank correlation was used to study relationships among sectoral developments. Kruskal Wallis test indicated significant changes in development level of industry and infrastructure sectors over the periods 1991-92, 2001-02 and 2011-12

A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma has Potent Anti-tumor Activity

Multiple myeloma is incurable and invariably becomes resistant to chemotherapy. Although the mechanisms remain unclear, hypoxic conditions in the bone marrow have been implicated in contributing to multiple myeloma progression, angiogenesis, and resistance to chemotherapy. These effects occur via adaptive cellular responses mediated by hypoxia-inducible transcription factors (HIF), and targeting HIFs can have anticancer effects in both solid and hematologic malignancies. Here, it was found that in most myeloma cell lines tested, HIF1α, but not HIF2α expression was oxygen dependent, and this could be explained by the differential expression of the regulatory prolyl hydroxylase isoforms. The anti–multiple myeloma effects of a sequence-specific DNA-binding pyrrole-imidazole (Py-Im) polyamide (HIF-PA), which disrupts the HIF heterodimer from binding to its cognate DNA sequences, were also investigated. HIF-PA is cell permeable, localizes to the nuclei, and binds specific regions of DNA with an affinity comparable with that of HIFs. Most of the multiple myeloma cells were resistant to hypoxia-mediated apoptosis, and HIF-PA treatment could overcome this resistance in vitro. Using xenograft models, it was determined that HIF-PA significantly decreased tumor volume and increased hypoxic and apoptotic regions within solid tumor nodules and the growth of myeloma cells engrafted in the bone marrow. This provides a rationale for targeting the adaptive cellular hypoxic response of the O_2-dependent activation of HIFα using polyamides

Оценка эндоскопической картины и микробного пейзажа бронхиального дерева при хронических неспецифических заболеваниях легких у детей

БРОНХОСКОПИЯДЕТИ, СЛУЖБЫ ОХРАНЫ ЗДОРОВЬЯЛЕГКИХ БОЛЕЗНИ ОБСТРУКТИВНЫ