Prevention and treatment of parasitic infections in organic pigs

Organic and free range pigs are potentially exposed to a wider range of parasites and zoonotic challenges. The livestock Subproject QLIF addresses 4 strategies to combat these challenges, and the present paper describes the initial results. Rodent control is the first strategy, and a survey concludes that Salmonella and Campylobacter infections were encountered in house mice and Norway rats, but not in other species. T. gondii antibodies could be detected in 6.4% of the blood samples taken from 235 wild small mammals. To reduce the presence of rodents around farms, the use of live-traps may be a good alternative for the use of rodenticides on organic farms. A second strategy is aimed at directing pig dunging behaviour in such a way that contact with (infected) faeces is minimised. The study showed that a rooting area resulted in a cleaner outdoor are and an extra outdoor drinker led to a cleaner area around the drinker, but to a dirtier indoor area. However, no difference in Ascaris suum infection were found. The nutritional strategy tested showed that pure inulin appeared the most effective as Oesophagostomum dentatum presence was reduced by 91%. Finally, as part of Strategy 4, a mixture of dried Thymus vulgaris, Melissa officinalis and Echinacea purpurea in a dosage of 5% in the diet showed to be preventive against a mild round-worm infection. The same mixture, however, was not effective in a lower dosage (3% in the diet) against a serious round-worm infection. Work is continuing to develop the above strategies further

Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans

In conventional phase-resolved OCT blood flow is detected from phase changes between successive A-scans. Especially in high-speed OCT systems this results in a short evaluation time interval. This method is therefore often unable to visualize complete vascular networks since low flow velocities cause insufficient phase changes. This problem was solved by comparing B-scans instead of successive A-scans to enlarge the time interval. In this paper a detailed phase-noise analysis of our OCT system is presented in order to calculate the optimal time intervals for visualization of the vasculature of the human retina and choroid. High-resolution images of the vasculature of a healthy volunteer taken with various time intervals are presented to confirm this analysis. The imaging was performed with a backstitched B-scan in which pairs of small repeated B-scans are stitched together to independently control the time interval and the imaged lateral field size. A time interval of ≥2.5 ms was found effective to image the retinal vasculature down to the capillary level. The higher flow velocities of the choroid allowed a time interval of 0.64 ms to reveal its dense vasculature. Finally we analyzed depth-resolved histograms of volumetric phase-difference data to assess changes in amount of blood flow with depth. This analysis indicated different flow regimes in the retina and the choroid. © 2012 Optical Society of America

Stress-strain behavior and geometrical properties of packings of elongated particles

We present a numerical analysis of the effect of particle elongation on the quasistatic behavior of sheared granular media by means of the Contact Dynamics method. The particle shapes are rounded-cap rectangles characterized by their elongation. The macroscopic and microstructural properties of several packings subjected to biaxial compression are analyzed as a function of particle elongation. We find that the shear strength is an increasing linear function of elongation. Performing an additive decomposition of the stress tensor based on a harmonic approximation of the angular dependence of branch vectors, contact normals and forces, we show that the increasing mobilization of friction force and the associated anisotropy are key effects of particle elongation. These effects are correlated with partial nematic ordering of the particles which tend to be oriented perpendicular to the major principal stress direction and form side-to-side contacts. However, the force transmission is found to be mainly guided by cap-to-side contacts, which represent the largest fraction of contacts for the most elongated particles. Another interesting finding is that, in contrast to shear strength, the solid fraction first increases with particle elongation, but declines as the particles become more elongated. It is also remarkable that the coordination number does not follow this trend so that the packings of more elongated particles are looser but more strongly connected.Comment: Submited to Physical Review

Real-time eye motion correction in phase-resolved OCT angiography with tracking SLO

In phase-resolved OCT angiography blood flow is detected from phase changes in between A-scans that are obtained from the same location. In ophthalmology, this technique is vulnerable to eye motion. We address this problem by combining inter-B-scan phase-resolved OCT angiography with real-time eye tracking. A tracking scanning laser ophthalmoscope (TSLO) at 840 nm provided eye tracking functionality and was combined with a phase-stabilized optical frequency domain imaging (OFDI) system at 1040 nm. Real-time eye tracking corrected eye drift and prevented discontinuity artifacts from (micro)saccadic eye motion in OCT angiograms. This improved the OCT spot stability on the retina and consequently reduced the phase-noise, thereby enabling the detection of slower blood flows by extending the inter-B-scan time interval. In addition, eye tracking enabled the easy compounding of multiple data sets from the fovea of a healthy volunteer to create high-quality eye motion artifact-free angiograms. High-quality images are presented of two distinct layers of vasculature in the retina and the dense vasculature of the choroid. Additionally we present, for the first time, a phase-resolved OCT angiogram of the mesh-like network of the choriocapillaris containing typical pore openings. © 2012 Optical Society of America

The anisotropy of granular materials

The effect of the anisotropy on the elastoplastic response of two dimensional packed samples of polygons is investigated here, using molecular dynamics simulation. We show a correlation between fabric coefficients, characterizing the anisotropy of the granular skeleton, and the anisotropy of the elastic response. We also study the anisotropy induced by shearing on the subnetwork of the sliding contacts. This anisotropy provides an explanation to some features of the plastic deformation of granular media.Comment: Submitted to PR

Towards a framework to evaluate the ‘total’ performance of buildings

Internationally, buildings are a major contributor to carbon emissions. Despite significant advances in the technology and construction of energy-efficient buildings, in many cases a performance gap between designed and actual performance exists. While much research has investigated the drivers of the building energy performance gap – both static and transient– there has been considerably less research into the total performance gap, defined here as performance gaps in building energy use, occupant satisfaction and Indoor Environmental Quality parameters such as thermal comfort and air quality which may impact on occupant health and wellbeing. This paper presents a meta-analysis of building performance data from buildings in the UK and China – selected due to their contrasting development environments – which illustrate the presence of and complexities of evaluating total performance gaps in both countries. The data demonstrate the need for (1) high end-use, spatial granularity and temporal resolution data for both energy and Indoor Environmental Quality, and (2) developing methodologies that allow meaningful comparisons between buildings internationally to facilitate learning from successful building design, construction methodologies and policy environments internationally. Using performance data from a UK building, a potential forward path is illustrated with the objective of developing a framework to evaluate total building performance. Practical application: While much research has examined building energy performance gaps, Indoor Environmental Quality and occupant satisfaction gaps are rarely included despite their relationship to energy. We use a meta-analysis of energy, indoor environmental quality, and occupant satisfaction data from buildings in the UK and China to illustrating the presence of and complexities of evaluating total performance gaps for buildings in the two countries, and the need for high resolution dynamic buildings data and novel methodologies for comparison between buildings across different contexts. Illustrative case studies are used to demonstrate potential future directions for evaluating ‘total’ building performance

Quantum Monte Carlo Calculations of Pion Scattering from Li

We show that the neutron and proton transition densities predicted by recent quantum Monte Carlo calculations for A=6,7 nuclei are consistent with pion scattering from 6Li and 7Li at energies near the Delta resonance. This has provided a microscopic understanding of the enhancement factors for quadrople excitations, which were needed to describe pion inelastic scattering within the nuclear shell model of Cohen and Kurath.Comment: 10 pages, REVTeX, 3 postscript figures; added calculation of elastic and inelastic pion scattering from 6Li at multiple energie

Extended M1 sum rule for excited symmetric and mixed-symmetry states in nuclei

A generalized M1 sum rule for orbital magnetic dipole strength from excited symmetric states to mixed-symmetry states is considered within the proton-neutron interacting boson model of even-even nuclei. Analytic expressions for the dominant terms in the B(M1) transition rates from the first and second $2^+$ states are derived in the U(5) and SO(6) dynamic symmetry limits of the model, and the applicability of a sum rule approach is examined at and in-between these limits. Lastly, the sum rule is applied to the new data on mixed-symmetry states of 94Mo and a quadrupole d-boson ratio $nd(0^+_1)/nd(2^+_2) \approx 0.6$ is obtained in a largely parameter-independent wayComment: 19 pages, 3 figures, Revte

Rheophysics of dense granular materials : Discrete simulation of plane shear flows

We study the steady plane shear flow of a dense assembly of frictional, inelastic disks using discrete simulation and prescribing the pressure and the shear rate. We show that, in the limit of rigid grains, the shear state is determined by a single dimensionless number, called inertial number I, which describes the ratio of inertial to pressure forces. Small values of I correspond to the quasi-static regime of soil mechanics, while large values of I correspond to the collisional regime of the kinetic theory. Those shear states are homogeneous, and become intermittent in the quasi-static regime. When I increases in the intermediate regime, we measure an approximately linear decrease of the solid fraction from the maximum packing value, and an approximately linear increase of the effective friction coefficient from the static internal friction value. From those dilatancy and friction laws, we deduce the constitutive law for dense granular flows, with a plastic Coulomb term and a viscous Bagnold term. We also show that the relative velocity fluctuations follow a scaling law as a function of I. The mechanical characteristics of the grains (restitution, friction and elasticity) have a very small influence in this intermediate regime. Then, we explain how the friction law is related to the angular distribution of contact forces, and why the local frictional forces have a small contribution to the macroscopic friction. At the end, as an example of heterogeneous stress distribution, we describe the shear localization when gravity is added.Comment: 24 pages, 19 figure