Influence of the degree of adherence to the mediterranean diet and its components on cardiometabolic risk during pregnancy. The GESTAFIT project

The study was funded by the Regional Ministry of Health of the Junta de Andalucia (PI-0395-2016) and the University of Granada, Unit of Excellence on Exercise and Health (UCEES) . MFA was additionally funded by the Spanish Ministry of Education, Culture and Sports (Grant number FPU17/03715) . The funders of the study had no role in the design of the study, data collection, data analysis or data interpretation. This study is included in the thesis of MFA enrolled in the Doctoral Programme in Nutrition and Food Sciences of the University of Granada.Background and aims: Studies regarding dietary patterns and cardiometabolic risk markers during pregnancy are scarce. The aim of the present study was to analyse whether different degrees of adherence to the Mediterranean diet (MD) and the MD components were associated with cardiometabolic markers and a clustered cardiometabolic risk during pregnancy. Methods and results: This study comprised 119 pregnant women from the GEStation and FITness (GESTAFIT) project. Dietary habits were assessed with a food frequency questionnaire at the 16th and 34th gestational weeks (g.w.). The Mediterranean Diet Score was employed to assess MD adherence. The following cardiometabolic markers were assessed: pre-pregnancy body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose, triglycerides and high-density lipoprotein cholesterol (HDL-C). A greater MD adherence was associated with a better cardiometabolic status in cross-sectional (16th g.w. and 34th g.w.) and prospective analyses (MD adherence at the 16th g.w. and cardiometabolic markers at the 34th g.w.; SBP, DBP and HDL-C; all, p < 0.05). Participants with the highest MD adherence (Tertile 3) had a lower clustered cardiometabolic risk than those with the lowest MD adherence (Tertile 1) at the 16th and 34th g.w. (both, p < 0.05). A higher intake of fruits, vegetables and fish and a lower intake of refined cereals and red meat and subproducts were associated with a lower cardiometabolic risk during pregnancy (all, p < 0.05). Conclusion: A higher MD adherence, a greater intake of fruits, vegetables and fish and a lower intake of refined cereals and red meat and subproducts showed a cardioprotective effect throughout gestation.Regional Ministry of Health of the Junta de Andalucia PI-0395-2016University of Granada, Unit of Excellence on Exercise and Health (UCEES)Spanish Ministry of Education, Culture and Sports FPU17/0371

Predictors and outcomes in primary depression care (POKAL) – a research training group develops an innovative approach to collaborative care

BACKGROUND: The interdisciplinary research training group (POKAL) aims to improve care for patients with depression and multimorbidity in primary care. POKAL includes nine projects within the framework of the Chronic Care Model (CCM). In addition, POKAL will train young (mental) health professionals in research competences within primary care settings. POKAL will address specific challenges in diagnosis (reliability of diagnosis, ignoring suicidal risks), in treatment (insufficient patient involvement, highly fragmented care and inappropriate long-time anti-depressive medication) and in implementation of innovations (insufficient guideline adherence, use of irrelevant patient outcomes, ignoring relevant context factors) in primary depression care. METHODS: In 2021 POKAL started with a first group of 16 trainees in general practice (GPs), pharmacy, psychology, public health, informatics, etc. The program is scheduled for at least 6 years, so a second group of trainees starting in 2024 will also have three years of research-time. Experienced principal investigators (PIs) supervise all trainees in their specific projects. All projects refer to the CCM and focus on the diagnostic, therapeutic, and implementation challenges. RESULTS: The first cohort of the POKAL research training group will develop and test new depression-specific diagnostics (hermeneutical strategies, predicting models, screening for suicidal ideation), treatment (primary-care based psycho-education, modulating factors in depression monitoring, strategies of de-prescribing) and implementation in primary care (guideline implementation, use of patient-assessed data, identification of relevant context factors). Based on those results the second cohort of trainees and their PIs will run two major trials to proof innovations in primary care-based a) diagnostics and b) treatment for depression. CONCLUSION: The research and training programme POKAL aims to provide appropriate approaches for depression diagnosis and treatment in primary care

Display data on categories of total (geological) reserves of uranium in Serbia in classes of mineral reserves from the current legislative

Geological data on the results of the research and on the 'determined masses of reserves', i.e. the total (geological) reserves of nuclear mineral resources, uranium and thorium in Serbia, were obtained by research carried out in accordance with the legal regulations of SFR Yugoslavia and of SR Serbia. In this paper, the mentioned data are considered in the light of the newly adopted concepts, mineral resources and reserves from the Law on Mining and Geological Exploration of the Republic of Serbia (Official Gazette of RS No. 101/15). By the moratorium on the construction of nuclear power plants in the SFR Yugoslavia in 1989 and the Law on the Prohibition of the Construction of Nuclear Power Plants in the Federal Republic of Yugoslavia (1995), half-century geological exploration of nuclear mineral raw materials started in 1948/1949 was interrupted. With this interruption, the many uranium occurrences and uranium deposits remained unexplored and unrated, and the separate categories of reserves B + C1 + C2 + D1 + D2 were not balanced, which reflects the low level of their research. Data on the total uranium reserves of categories B + C1 + C2 + D1 + D2 in Serbia, in the amount of 19 651 680 t or 13 537 779 t [14], are (with appropriate correction) shown via the 'established' conversion map (as a Bridging Document) in the classes of superiors , indicated and measured mineral resources (in situ) from the current Serbian law. The position of the author of the paper is to present the existing data on the total (geological) uranium reserves in the newly introduced terms from the current law and as such approximate to the interested users

The role of maintenance therapy in multiple myeloma

AbstractMultiple myeloma is the second most common type of blood cancer and remains incurable despite advances in therapy. Current therapy for multiple myeloma includes a phased-approach, often consisting of initial induction therapy, consolidation and maintenance therapy. With an ever-growing landscape of treatment options, the approach to optimal therapy has become increasingly complex. Specifically, controversy surrounds the optimal use and duration of maintenance therapy. We conducted a comprehensive literature search to analyze the most current literature and to provide recommendations for maintenance therapy in multiple myeloma.</jats:p

Risk assessment by the occupational safety and health at work in the process of geological exploration

This paper presents a model of risk assessment in terms of safety and health at work in the process of geological work/ drilling. Optimization model estimates OH & S risk for work place qualified driller, is in line with the provisions of the Mining and Geological exploration, the Law on Safety and Health at Work, the application of the requirements of ISO 31000 and criteria Kinny methods. Model estimates OH & S risks is the basis for the development and implementation of the management system of protection of health and safety at work according to BS OHSAS 18001: 2008 model is applied, checked and verified the approved exploration areas during execution and supervision applied geological exploration (of metals) on the territory of the Republic of Serbia