1,710 research outputs found

    USING CENSUS BUREAU STATISTICS ON GOVERNMENTAL FINANCES

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    This report (1) briefly describes the way in which Census Bureau statistics on governmental finances are collected, (2) provides some guidelines concerning the use of these statistics, (3) defines some of the terms used in classifying governmental finances, and (4) lists the major publications on state and local governments issued by the Census Bureau.Public Economics,

    Los dos canales de transmisión de la política monetaria en una economía dolarizada

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    The purpose of this paper is to study the transmission mechanism of monetary policy under an institutional framework characterized by a dollarized banking system, a flexible exchange rate and free capital movements. The main result of this study is that a restrictive monetary policy can reactivate the economy if the share of their private debt in dollars is greater. Since a restrictive monetary policy increases the domestic interest rate and appreciates the exchange rate, the real burden of private debt can be reduced, and to increase the private expensive.

    THE NEW FEDERALISM: HOW WOULD IT AFFECT MINNESOTA?

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    Community/Rural/Urban Development, Political Economy,

    Electronic Data Transmission Pathways: Implications for Site Selection

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    Current technology and cost of on-site data transmission hardware, site communications channels, and interface equipment allow a firm the capability to routinely achieve both high speed and high quality of data transmission. However, the firm can easily exceed the capability of a common carrier's local and regional pathways (lines and switch gear), resulting in reduced cost effectiveness of business operations. This study presents a telecommunications evaluation structure that can be integrated into the firm's site selection and facilities planning decision framework. This structure is used to assess the capability of sites to meet required telecommunications support. Additional considerations affecting data transmission capability are included to assist the analyst in the evaluation progress.

    Comparación entre nutrición enteral precoz y nutrición enteral tardía en el estado nutricional de pacientes gastrectomizados

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    Indexación: ScieloLa nutrición enteral (NE) es un método efectivo para cubrir los requerimientos nutricionales en pacientes que presentan un estado nutricional deteriorado. Objetivos: Comparar la Nutrición Enteral Precoz (NEP) versus Nutrición Enteral Tardía (NET) en la evolución clínica y nutricional de pacientes sometidos a gastrectomía total por Cáncer Gástrico. Material y Método: 18 pacientes con cáncer gástrico resecable, fueron estudiados con parámetros antropométricos, funcionales y bioquímicos que evalúan el estado nutricional, en el período preoperatorio y postoperatorio. Recibieron una fórmula enteral polimérica (1 kcal/ml) en el período postoperatorio. De manera aleatoria fueron asignados al tipo de nutrición (precoz o tardía). Resultados: El grupo con NEP presentó mejoría significativa del porcentaje de adecuación del pliegue bicipital y dinamometría. El grupo con NET presentó disminución significativa de la albuminemia. La distensión abdominal fue más frecuente en grupo con NEP. Conclusión: La Nutrición Enteral Precoz es un soporte nutricional seguro, eficaz y que trae consigo ventajas nutricionales en comparación con la Nutrición Enteral Tardía en el grupo de pacientes gastrectomizados totales por presentar cáncer gástrico.Enteral nutrition (EN) is an effective method to meet the nutritional requirements in patients who have a deteriorated nutritional status. Objectives: To compare clinical and nutritional performance oftwo groups: Early Enteral Nutrition (EEN) versus Late Enteral Nutrition (LEN) of patients undergoing to total gastrectomy for gastric cancer. Material and Methods: 18 patients with resectable gastric cancer were studied with anthropometric, functional and biochemical parameters to assess nutritional status in the preoperative and postoperative period. They received a polimeric enteral formula (1 kcal/ml) in the postoperative period. They were randomly assigned to the type of nutrition (early or late). Results: The group with EEN had a significant improvement in the bicipital fold adequacy percentage and dynamometry. The LEN group had a significant decrease of albumin. The bloating was more fre quent in the group with EEN. Conclusion: Early enteral nutrition is a safe nutritional support, effective and that brings nutritional benefits compared with late enteral nutrition in patients undergoing to total gastrectomy for gastric cancer.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182009000100002&nrm=is

    Artificial escape from XCI by DNA methylation editing of the CDKL5 gene.

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    A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here, we created an artificial escape by editing DNA methylation on the promoter of CDKL5, a gene causative for an infantile epilepsy, from the silenced X-chromosomal allele in human neuronal-like cells. We identify that a fusion of the catalytic domain of TET1 to dCas9 targeted to the CDKL5 promoter using three guide RNAs causes significant reactivation of the inactive allele in combination with removal of methyl groups from CpG dinucleotides. Strikingly, we demonstrate that co-expression of TET1 and a VP64 transactivator have a synergistic effect on the reactivation of the inactive allele to levels >60% of the active allele. We further used a multi-omics assessment to determine potential off-targets on the transcriptome and methylome. We find that synergistic delivery of dCas9 effectors is highly selective for the target site. Our findings further elucidate a causal role for reduced DNA methylation associated with escape from X chromosome inactivation. Understanding the epigenetics associated with escape from X chromosome inactivation has potential for those suffering from X-linked disorders
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