Optimal adult growth of Daphnia in a seasonal environment

1. The cladoceran Daphnia serves as an example of an iteroparous organism, with overlapping generations, that is capable of substantial adult growth. The life history of Daphnia was modelled as the consequence of a series of decisions about allocation of energetic resources to growth and reproduction. 2. We used numerical methods to find resource allocation patterns that maximized fitness of Daphnia in a temporally variable environment. Temporal variation was modelled as alternating active and dormant seasons; length of the active season was uniformly distributed. Fitness was measured by the geometric mean of resting eggs produced at the end of the active season. We examined effects of mean and range of the active season on the optimal life history; we also examined effects of increasing (invertebrate predation), constant (non-selective) and decreasing (fish) size-specific survival rates. For comparison, we found resource allocation patterns that maximized fitness in a constant environment, where fitness was measured by the intrinsic rate of increase r. 3. Life histories optimized for seasonal environments generally showed earlier maturity and greater adult growth than those optimized for constant environments. Adult growth occurred with non-selective predation, and even with fish predation, conditions under which it does not occur in the optimal life histories for constant environments. 4. Greatest size at maturity and adult growth occurred in life histories optimized to invertebrate predation in seasonal environments. Smallest size at maturity and least adult growth occurred in life histories optimized to fish predation. 5. In the optimal life histories, size at maturity generally increased with mean length of the active season. Adult growth reached a maximum for mean seasons of length equal to about one-half to one life span of Daphnia. 6. Increasing the variation in season length decreased adult growth in the optimal life history, but had little effect on size at maturity. 7. We expect that life histories are adapted to the long-term average of season length and its variation. If the animals can detect the type of predator, selection could favour phenotypic variation in resource allocation

Histamine release after intravenous application of short-acting hypnotics. A comparison of etomidate, Althesin (CT1341) and propanidid

The subject of histamine release was investigated in 16 volunteers by means of plasma histamine determination after the administration of etornidate, Althesin, propanidid, and Cremophor EL. Althesin and propanidid caused release of histamine in various degrees of frequency. Blood pressure changes were rather pronounced with both anaesthetic agents; tachycardia reached its maximum in the first and second minute, which seems to be an argument against histamine release as the underlying cause of this reaction. Histamine was, indeed, only released to such an extent (with the exception of one borderline case) that no clinical symptoms other than secretion of gastric juice and erythema were to be expected. After the application of etomidate and Cremophor EL an increase in plasma histamine was not detectable. Changes in the differential blood picture in terms of a decrease in basophils only occurred after Althesin and propanidid; not, however, after etomidate and Cremophor EL. Etomidate is, therefore, the first hypnotic drug for intravenous application which is unlikely to cause chemical histamine release

Тестування як засіб контролю студентів в дистанційних курсах

Some questions of electronic testing in distance learning are concerned in the article: its importance in checking students’ knowledge, the main spheres of tests usage, testing possibilities in the virtual educational environment "Web-Class-KPI", special moments in criteria testings

Erosion at extended continental margins: Insights from new aerogeophysical data in eastern Dronning Maud Land

Modelling-, rock cooling-, sedimentation- and exposure-based interpretations of the mechanisms by which topography evolves at extended continental margins vary widely. Observations from the margin of Dronning Maud Land, Antarctica, have until now not strongly contributed to these interpretations. Here, we present new airborne gravity and radar data describing the eastern part of this margin. Inland of a tall (2.5 km) great escarpment, a plateau topped by a branching network of valleys suggests preservation of a fluvial landscape with SW-directed drainage beneath a cold-based ice sheet. The valley floor slopes show that this landscape was modified during a period of alpine-style glaciation prior to the onset of the current cold-based phase around 34 Ma. The volume of sediments in basins offshore in the Riiser-Larsen Sea balances with the volume of rock estimated to have been eroded and transported by north-directed drainage from between the escarpment and the continental shelf break. The stratigraphy of these basins shows that most of the erosion occurred during the ~40 Myr following late Jurassic continental breakup. This erosion is unlikely to have been dominated by backwearing because the required rate of escarpment retreat to its present location is faster than numerical models of landscape evolution suggest to be possible. We suggest an additional component of erosion by downwearing seawards of a pre-existing inland drainage divide. The eastern termination of the great escarpment and inland plateau is at the West Ragnhild trough, a 300 km long, 15–20 km wide and up to 1.6 km deep subglacial valley hosting the West Ragnhild glacier. Numerous overdeepened (by >300 m) segments of the valley floor testify to its experience of significant glacial erosion. Thick late Jurassic and early Cretaceous sediments fanning out from the trough's mouth into the eastern Riiser-Larsen Sea betray an earlier history as a river valley. The lack of late Jurassic relief-forming processes in this river's catchment in the interior of East Antarctica suggests this erosion was related to regional climatic change

Miocene uplift of the NE Greenland margin linked to plate tectonics: Seismic evidence from the Greenland Fracture Zone, NE Atlantic:Margin Uplift and Plate Tectonics

Tectonic models predict that following breakup, rift margins undergo only decaying thermal subsidence during their postrift evolution. However, postbreakup stratigraphy beneath the NE Atlantic shelves shows evidence of regional-scale unconformities, commonly cited as outer margin responses to inner margin episodic uplift, including the formation of coastal mountains. The origin of these events remains enigmatic. We present a seismic reflection study from the Greenland Fracture Zone-East Greenland Ridge (GFZ-EGR) and the NE Greenland shelf. We document a regional intra-Miocene seismic unconformity (IMU), which marks the termination of synrift deposition in the deep-sea basins and onset of (i) thermomechanical coupling across the GFZ, (ii) basin compression, and (iii) contourite deposition, north of the EGR. The onset of coupling across the GFZ is constrained by results of 2-D flexural backstripping. We explain the thermomechanical coupling and the deposition of contourites by the formation of a continuous plate boundary along the Mohns and Knipovich ridges, leading to an accelerated widening of the Fram Strait. We demonstrate that the IMU event is linked to onset of uplift and massive shelf progradation on the NE Greenland margin. Given an estimated middle to late Miocene (~15–10Ma) age of the IMU, we speculate that the event is synchronous with uplift of the east and west Greenland margins. The correlation between margin uplift and plate motion changes further indicates that the uplift was triggered by plate tectonic forces, induced perhaps by a change in the Iceland plume (a hot pulse) and/or by changes in intraplate stresses related to global tectonics

A quantitative framework for characterizing the evolutionary history of mammalian gene expression

The evolutionary history of a gene helps predict its function and relationship to phenotypic traits. Although sequence conservation is commonly used to decipher gene function and assess medical relevance, methods for functional inference from comparative expression data are lacking. Here, we use RNA-seq across seven tissues from 17 mammalian species to show that expression evolution across mammals is accurately modeled by the Ornstein–Uhlenbeck process, a commonly proposed model of continuous trait evolution. We apply this model to identify expression pathways under neutral, stabilizing, and directional selection. We further demonstrate novel applications of this model to quantify the extent of stabilizing selection on a gene’s expression, parameterize the distribution of each gene’s optimal expression level, and detect deleterious expression levels in expression data from individual patients. Our work provides a statistical framework for interpreting expression data across species and in disease