A distributed analysis and visualization system for model and observational data

Software was developed with NASA support to aid in the analysis and display of the massive amounts of data generated from satellites, observational field programs, and from model simulations. This software was developed in the context of the PATHFINDER (Probing ATmospHeric Flows in an Interactive and Distributed EnviRonment) Project. The overall aim of this project is to create a flexible, modular, and distributed environment for data handling, modeling simulations, data analysis, and visualization of atmospheric and fluid flows. Software completed with NASA support includes GEMPAK analysis, data handling, and display modules for which collaborators at NASA had primary responsibility, and prototype software modules for three-dimensional interactive and distributed control and display as well as data handling, for which NSCA was responsible. Overall process control was handled through a scientific and visualization application builder from Silicon Graphics known as the Iris Explorer. In addition, the GEMPAK related work (GEMVIS) was also ported to the Advanced Visualization System (AVS) application builder. Many modules were developed to enhance those already available in Iris Explorer including HDF file support, improved visualization and display, simple lattice math, and the handling of metadata through development of a new grid datatype. Complete source and runtime binaries along with on-line documentation is available via the World Wide Web at: http://redrock.ncsa.uiuc.edu/ PATHFINDER/pathre12/top/top.html

Negative-Energy Perturbations in Circularly Cylindrical Equilibria within the Framework of Maxwell-Drift Kinetic Theory

The conditions for the existence of negative-energy perturbations (which could be nonlinearly unstable and cause anomalous transport) are investigated in the framework of linearized collisionless Maxwell-drift kinetic theory for the case of equilibria of magnetically confined, circularly cylindrical plasmas and vanishing initial field perturbations. For wave vectors with a non-vanishing component parallel to the magnetic field, the plane equilibrium conditions (derived by Throumoulopoulos and Pfirsch [Phys Rev. E {\bf 49}, 3290 (1994)]) are shown to remain valid, while the condition for perpendicular perturbations (which are found to be the most important modes) is modified. Consequently, besides the tokamak equilibrium regime in which the existence of negative-energy perturbations is related to the threshold value of 2/3 of the quantity $\eta_\nu = \frac {\partial \ln T_\nu} {\partial \ln N_\nu}$, a new regime appears, not present in plane equilibria, in which negative-energy perturbations exist for {\em any} value of $\eta_\nu$. For various analytic cold-ion tokamak equilibria a substantial fraction of thermal electrons are associated with negative-energy perturbations (active particles). In particular, for linearly stable equilibria of a paramagnetic plasma with flat electron temperature profile ($\eta_e=0$), the entire velocity space is occupied by active electrons. The part of the velocity space occupied by active particles increases from the center to the plasma edge and is larger in a paramagnetic plasma than in a diamagnetic plasma with the same pressure profile. It is also shown that, unlike in plane equilibria, negative-energy perturbations exist in force-free reversed-field pinch equilibria with a substantial fraction of active particles.Comment: 31 pages, late

Observational Analysis of the 27 May 1997 Central Texas Tornadic Event. Part II: Tornadoes

The 27 May 1997 central Texas tornadic event has been investigated in a two-part observational study. As demonstrated in Part I, the 1D environment associated with this event was unfavorable for significant (≥F2) tornadoes. Yet, the storm complex produced at least six significant tornadoes, including one rated F5 (the Jarrell, Texas, tornado). The purpose of this article is to examine the spatiotemporal interrelationships between tornadoes, preexisting boundaries, antecedent low-level mesocyclones, convective cells, and midlevel mesocyclones. It is shown that each of the six observed tornadoes that produced greater than F0 damage formed along the storm-generated gust front, not along preexisting boundaries. Half of these tornadoes formed on the distorted gust front, the portion of the storm-generated gust front whose orientation was deformed largely by the horizontal shear across the cold front. The remaining three tornadoes developed at the gust front cusp (the persistent gust front inflection located at the northeast end of the gust front distortion). Unlike the tornadoes south of the gust front cusp, these tornadoes are found to be associated with antecedent mesocyclones located in the low levels above the boundary layer. Furthermore, these mesocyclonic tornadoes are found to be larger and more destructive than the three nonmesocyclonic tornadoes. The formation of the Jarrell tornado is found to occur as a nearly stationary convective cell became collocated with a south-southwestward-moving low-level mesocyclone near the gust front cusp—a behavior that resembles the formation of nonsupercell tornadoes. It is argued that the back-building propagation/maintenance of the storm complex enabled this juxtaposition of convective cells with vorticity along the distorted gust front and may have therefore enabled tornado formation. Each of the convective cells without midlevel mesocyclones was found to remain farther from the boundaries than the mesocyclonic cells. Since the cells nearest to the boundaries were longer lived than the remaining cells, it is argued that cells near the boundaries were mesocyclonic because the boundaries yielded cells that were more likely to support temporally coherent midlevel rotation

Negative-energy perturbations in cylindrical equilibria with a radial electric field

The impact of an equilibrium radial electric field $E$ on negative-energy perturbations (NEPs) (which are potentially dangerous because they can lead to either linear or nonlinear explosive instabilities) in cylindrical equilibria of magnetically confined plasmas is investigated within the framework of Maxwell-drift kinetic theory. It turns out that for wave vectors with a non-vanishing component parallel to the magnetic field the conditions for the existence of NEPs in equilibria with E=0 [G. N. Throumoulopoulos and D. Pfirsch, Phys. Rev. E 53, 2767 (1996)] remain valid, while the condition for the existence of perpendicular NEPs, which are found to be the most important perturbations, is modified. For $|e_i\phi|\approx T_i$ ($\phi$ is the electrostatic potential) and $T_i/T_e > \beta_c\approx P/(B^2/8\pi)$ ($P$ is the total plasma pressure), a case which is of operational interest in magnetic confinement systems, the existence of perpendicular NEPs depends on $e_\nu E$, where $e_\nu$ is the charge of the particle species $\nu$. In this case the electric field can reduce the NEPs activity in the edge region of tokamaklike and stellaratorlike equilibria with identical parabolic pressure profiles, the reduction of electron NEPs being more pronounced than that of ion NEPs.Comment: 30 pages, late

An interactive environment for the analysis of large Earth observation and model data sets

Envision is an interactive environment that provides researchers in the earth sciences convenient ways to manage, browse, and visualize large observed or model data sets. Its main features are support for the netCDF and HDF file formats, an easy to use X/Motif user interface, a client-server configuration, and portability to many UNIX workstations. The Envision package also provides new ways to view and change metadata in a set of data files. It permits a scientist to conveniently and efficiently manage large data sets consisting of many data files. It also provides links to popular visualization tools so that data can be quickly browsed. Envision is a public domain package, freely available to the scientific community. Envision software (binaries and source code) and documentation can be obtained from either of these servers: ftp://vista.atmos.uiuc.edu/pub/envision/ and ftp://csrp.tamu.edu/pub/envision/. Detailed descriptions of Envision capabilities and operations can be found in the User's Guide and Reference Manuals distributed with Envision software

Design of a randomized controlled study of a multi-professional and multidimensional intervention targeting frail elderly people

<p>Abstract</p> <p>Background</p> <p>Frail elderly people need an integrated and coordinated care. The two-armed study "Continuum of care for frail elderly people" is a multi-professional and multidimensional intervention for frail community-dwelling elderly people. It was designed to evaluate whether the intervention programme for frail elderly people can reduce the number of visits to hospital, increase satisfaction with health and social care and maintain functional abilities. The implementation process is explored and analysed along with the intervention. In this paper we present the study design, the intervention and the outcome measures as well as the baseline characteristics of the study participants.</p> <p>Methods/design</p> <p>The study is a randomised two-armed controlled trial with follow ups at 3, 6 and 12 months. The study group includes elderly people who sought care at the emergency ward and discharged to their own homes in the community. Inclusion criteria were 80 years and older <it>or </it>65 to 79 years with at least one chronic disease and dependent in at least one activity of daily living. Exclusion criteria were acute severely illness with an immediate need of the assessment and treatment by a physician, severe cognitive impairment and palliative care. The intention was that the study group should comprise a representative sample of frail elderly people at a high risk of future health care consumption. The intervention includes an early geriatric assessment, early family support, a case manager in the community with a multi-professional team and the involvement of the elderly people and their relatives in the planning process.</p> <p>Discussion</p> <p>The design of the study, the randomisation procedure and the protocol meetings were intended to ensure the quality of the study. The implementation of the intervention programme is followed and analysed throughout the whole study, which enables us to generate knowledge on the process of implementing complex interventions. The intervention contributes to early recognition of both the elderly peoples' needs of information, care and rehabilitation and of informal caregivers' need of support and information. This study is expected to show positive effects on frail elderly peoples' health care consumption, functional abilities and satisfaction with health and social care.</p> <p>Trial registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01260493">NCT01260493</a></p

Fidelity and moderating factors in complex interventions: a case study of a continuum of care program for frail elderly people in health and social care

<p>Abstract</p> <p>Background</p> <p>Prior studies measuring fidelity of complex interventions have mainly evaluated adherence, and not taken factors affecting adherence into consideration. A need for studies that clarify the concept of fidelity and the function of factors moderating fidelity has been emphasized. The aim of the study was to systematically evaluate implementation fidelity and possible factors influencing fidelity of a complex care continuum intervention for frail elderly people.</p> <p>Methods</p> <p>The intervention was a systematization of the collaboration between a nurse with geriatric expertise situated at the emergency department, the hospital ward staff, and a multi-professional team with a case manager in the municipal care services for older people. Implementation was evaluated between September 2008 and May 2010 with observations of work practices, stakeholder interviews, and document analysis according to a modified version of The Conceptual Framework for Implementation Fidelity.</p> <p>Results</p> <p>A total of 16 of the 18 intervention components were to a great extent delivered as planned, while some new components were added to the model. No changes in the frequency or duration of the 18 components were observed, but the dose of the added components varied over time. Changes in fidelity were caused in a complex, interrelated fashion by all the moderating factors in the framework, i.e., context, staff and participant responsiveness, facilitation, recruitment, and complexity.</p> <p>Discussion</p> <p>The Conceptual Framework for Implementation Fidelity was empirically useful and included comprehensive measures of factors affecting fidelity. Future studies should focus on developing the framework with regard to how to investigate relationships between the moderating factors and fidelity over time.</p> <p>Trial registration</p> <p>ClinicalTrials.gov, <a href="http://www.clinicaltrials.gov/ct2/show/NCT01260493">NCT01260493</a>.</p

mTORC1-S6K Activation by Endotoxin Contributes to Cytokine Up-Regulation and Early Lethality in Animals

Background: mTORC1 (mammalian target of rapamycin complex 1) activation has been demonstrated in response to endotoxin challenge, but the mechanism and significance are unclear. We investigated the effect of mTORC1 suppression in an animal model of endotoxemia and in a cellular model of endotoxin signaling. Methodology/Principal Findings: Mice were treated with the mTORC1 inhibitor rapamycin or vehicle prior to lethal endotoxin challenge. Mortality and cytokine levels were assessed. Cultured macrophage-like cells were challenged with endotoxin with or without inhibitors of various pathways known to be upstream of mTORC1. Activated pathways, including downstream S6K pathway, were assessed by immunoblots. We found that mTORC1-S6K suppression by rapamycin delayed mortality of mice challenged with lethal endotoxin, and was associated with dampened circulating levels of VEGF, IL-1b, IFN-c and IL-5. Furthermore, in vitro cellular studies demonstrated that LPS (lipopolysaccharide) activation of mTORC1-S6K still occurs in the presence of PI3K-Akt inhibition alone, but can be suppressed by concurrent inhibition of PI3K-Akt and MEK-ERK pathways. Conclusions/Significance: We conclude that cellular activation of mTORC1-S6K contributes to cytokine up-regulation an

Obstructed Labor and Caesarean Delivery: The Cost and Benefit of Surgical Intervention

Background: Although advances in the reduction of maternal mortality have been made, up to 273,000 women will die this year from obstetric etiologies. Obstructed labor (OL), most commonly treated with Caesarean delivery, has been identified as a major contributor to global maternal morbidity and mortality. We used economic and epidemiological modeling to estimate the cost per disability-adjusted life-year (DALY) averted and benefit-cost ratio of treating OL with Caesarean delivery for 49 countries identified as providing an insufficient number of Caesarean deliveries to meet demand. Methods and Findings Using publicly available data and explicit economic assumptions, we estimated that the cost per DALY (3,0,0) averted for providing Caesarean delivery for OL ranged widely, from $251 per DALY averted in Madagascar to$3,462 in Oman. The median cost per DALY averted was $304. Benefit-cost ratios also varied, from 0.6 in Zimbabwe to 69.9 in Gabon. The median benefit-cost ratio calculated was 6.0. The main limitation of this study is an assumption that lack of surgical capacity is the main factor responsible for DALYs from OL. Conclusions: Using the World Health Organization's cost-effectiveness standards, investing in Caesarean delivery can be considered “highly cost-effective” for 48 of the 49 countries included in this study. Furthermore, in 46 of the 49 included countries, the benefit-cost ratio was greater than 1.0, implying that investment in Caesarean delivery is a viable economic proposition. While Caesarean delivery alone is not sufficient for combating OL, it is necessary, cost-effective by WHO standards, and ultimately economically favorable in the vast majority of countries included in this study