Observation of vortex-nucleated magnetization reversal in individual ferromagnetic nanotubes

The reversal of a uniform axial magnetization in a ferromagnetic nanotube (FNT) has been predicted to nucleate and propagate through vortex domains forming at the ends. In dynamic cantilever magnetometry measurements of individual FNTs, we identify the entry of these vortices as a function of applied magnetic field and show that they mark the nucleation of magnetization reversal. We find that the entry field depends sensitively on the angle between the end surface of the FNT and the applied field. Micromagnetic simulations substantiate the experimental results and highlight the importance of the ends in determining the reversal process. The control over end vortex formation enabled by our findings is promising for the production of FNTs with tailored reversal properties.Comment: 20 pages, 13 figure

Spin-aligned neutron-proton pair mode in atomic nuclei

Shell model calculations using realistic interactions reveal that the ground and low-lying yrast states of the $N=Z$ nucleus $^{92}_{46}$Pd are mainly built upon isoscalar neutron-proton pairs each carrying the maximum angular momentum J=9 allowed by the shell $0g_{9/2}$ which is dominant in this nuclear region. This structure is different from the ones found in the ground and low-lying yrast states of all other even-even nuclei studied so far. The low-lying spectrum of excited states generated by such correlated neutron-proton pairs has two distinctive features: i) the levels are almost equidistant at low energies and ii) the transition probability $I\rightarrow I-2$ is approximately constant and strongly selective. This unique mode is shown to replace normal isovector pairing as the dominating coupling scheme in $N=Z$ nuclei approaching the doubly-magic nucleus $^{100}$Sn.Comment: 11 pages, 5 figures, version to appear in Phys. Rev. C (Rapid communication

Imaging magnetic vortex configurations in ferromagnetic nanotubes

We image the remnant magnetization configurations of CoFeB and permalloy nanotubes (NTs) using x-ray magnetic circular dichroism photo-emission electron microscopy. The images provide direct evidence for flux-closure configurations, including a global vortex state, in which magnetization points circumferentially around the NT axis. Furthermore, micromagnetic simulations predict and measurements confirm that vortex states can be programmed as the equilibrium remnant magnetization configurations by reducing the NT aspect ratio.Comment: 14 pages, 4 figures, link to supplementary informatio

The Influence of the Degree of Heterogeneity on the Elastic Properties of Random Sphere Packings

The macroscopic mechanical properties of colloidal particle gels strongly depend on the local arrangement of the powder particles. Experiments have shown that more heterogeneous microstructures exhibit up to one order of magnitude higher elastic properties than their more homogeneous counterparts at equal volume fraction. In this paper, packings of spherical particles are used as model structures to computationally investigate the elastic properties of coagulated particle gels as a function of their degree of heterogeneity. The discrete element model comprises a linear elastic contact law, particle bonding and damping. The simulation parameters were calibrated using a homogeneous and a heterogeneous microstructure originating from earlier Brownian dynamics simulations. A systematic study of the elastic properties as a function of the degree of heterogeneity was performed using two sets of microstructures obtained from Brownian dynamics simulation and from the void expansion method. Both sets cover a broad and to a large extent overlapping range of degrees of heterogeneity. The simulations have shown that the elastic properties as a function of the degree of heterogeneity are independent of the structure generation algorithm and that the relation between the shear modulus and the degree of heterogeneity can be well described by a power law. This suggests the presence of a critical degree of heterogeneity and, therefore, a phase transition between a phase with finite and one with zero elastic properties.Comment: 8 pages, 6 figures; Granular Matter (published online: 11. February 2012

Common Creatine Kinase gene mutation results in falsely reassuring CK levels in muscle disorders

Introduction:Creatine Kinase(CK) is the enzyme responsible for catalysing the exchange of phosphates in the creatine/phosphocreatine shuttle(1). Skeletal muscle CK is made up of 90% muscle CK (CK-MM) and 10% heart CK (CK-MB). In muscle damage (e.g. rhabdomyolysis), extreme exercise and statin induced myositis, serum CK can be raised in excess of 10 times the upper limit of normal(4). However, the recent discovery of a single nucleotide polymorphism(SNP),rs11559024 in the CKM gene(5) results in an inability to produce skeletal muscle type CK and therefore low levels of CK in clinical scenarios that may result in crucial diagnosis such as rhabdomyolysis and statin-induced myositis being missed.Case Report:A female patient was found to be homozygous for rs11559024 with consistently low CK values. The patient had a past history of Type 2 Diabetes Mellitus, Chronic Kidney Disease and Peripheral Vascular Disease.Following an admission with extensive necrotising fasciitis, she underwent a debridement procedure for extensive necrotising fasciitis. Post-operative blood samples indicated her CK reached a maximum of 22 IU/L [nr 35-175IU/L] the day after her surgery. Whilst recovering this patient’s CK returned to 8 IU/L within 48hours after the operation. Further admissions in subsequent years for a hemicolectomy (for bowel cancer) also revealed significant blunting in her expected CK levels post-operatively. Her pre-operative CK of 34 IU/L remained relatively unchanged post-operatively (28 IU/L).Discussion:As a carrier of two copies of the rare allele at the SNP rs11559024 of her CKM gene, this patient was unable to produce measurable functioning skeletal muscle type creatine kinase resulting in consistently low serum CK even following necrotising fasciitis and open surgery. In her past history, the patient was also deemed “intolerant” to statins and was switched multiple times between different statins. Her CK levels were falsely reassuring when checked by clinicians looking for evidence of a statin-induced myositis. Learning Point for Clinicians:The mean allele frequency of this SNP is 0.02 (approx. 2.5 million people in the UK are carriers). Therefore, greater awareness of this CKM SNP is needed as there may be instances where the diagnosis of rhabdomyolysis, statin-induced myopathy, poly-/dermatomyositis and other muscle conditions that result in raised CK’s , is missed in these patients. <br/

Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice

Transforming growth factor-β (TGF-β) plays an important role in the development and maintenance of embryonic dopaminergic (DA) neurons in the midbrain. To study the function of TGF-β signaling in the adult nigrostriatal system, we generated transgenic mice with reduced TGF-β signaling in mature neurons. These mice display age-related motor deficits and degeneration of the nigrostriatal system. Increasing TGF-β signaling in the substantia nigra through adeno-associated virus expressing a constitutively active type I receptor significantly reduces 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration and motor deficits. These results suggest that TGF-β signaling is critical for adult DA neuron survival and that modulating this signaling pathway has therapeutic potential in Parkinson disease.SIGNIFICANCE STATEMENT We show that reducing Transforming growth factor-β (TGF-β) signaling promotes Parkinson disease-related pathologies and motor deficits, and increasing TGF-β signaling reduces neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a parkinsonism-inducing agent. Our results provide a rationale to pursue a means of increasing TGF-β signaling as a potential therapy for Parkinson's disease

Assessment of processing technologies which may improve the nutritional composition of dairy products – Overview of progress

Among consumers there is a growing demand for food products with a natural nutritional-physiological advantage over comparable conventional products. As part of an EU funded project, ALP is examining the possible impact of processing on nutritionally valuable milk components, using the example of conjugated linoleic acids (CLA). The extent to which processing influences the CLA content of the end product was determined by literature research and own investigations of organic and conventional butter. Furthermore, new chemical, sensory-based and bio crystallization methods were evaluated by ALP and the University of Kassel to determine the oxidation stability of butter. In a further step the storage stability of CLA enriched and conventional butter was examined and the different methods will be compared. As a third objective a process for low-input CLA enrichment of milk fat (with a focus on alpine butter) has been developed. Since the process selected for the work is a physical enrichment process, it is accepted by international organic farming and food groups. Among the many benefits ascribed to CLA, it is believed to be an effective agent against cancer. The demand for foods with properties that promote human health is growing. The dairy industry has the opportunity to meet this demand by developing new dairy products with a nutritional-physiological function for the functional food market

Diffusing-wave spectroscopy in a standard dynamic light scattering setup

Diffusing-wave spectroscopy (DWS) extends dynamic light scattering measurements to samples with strong multiple scattering. DWS treats the transport of photons through turbid samples as a diffusion process, thereby making it possible to extract the dynamics of scatterers from measured correlation functions. The analysis of DWS data requires knowledge of the path length distribution of photons traveling through the sample. While for flat sample cells this path length distribution can be readily calculated and expressed in analytical form; no such expression is available for cylindrical sample cells. DWS measurements have therefore typically relied on dedicated setups that use flat sample cells. Here we show how DWS measurements, in particular DWS-based microrheology measurements, can be performed in standard dynamic light scattering setups that use cylindrical sample cells. To do so we perform simple random-walk simulations that yield numerical predictions of the path length distribution as a function of both the transport mean free path and the detection angle. This information is used in experiments to extract the mean-square displacement of tracer particles in the material, as well as the corresponding frequency-dependent viscoelastic response. An important advantage of our approach is that by performing measurements at different detection angles, the average path length through the sample can be varied. For measurements performed on a single sample cell, this gives access to a wider range of length and time scales than obtained in a conventional DWS setup. Such angle-dependent measurements also offer an important consistency check, as for all detection angles the DWS analysis should yield the same tracer dynamics, even though the respective path length distributions are very different. We validate our approach by performing measurements both on aqueous suspensions of tracer particles and on solidlike gelatin samples, for which we find our DWS-based microrheology data to be in good agreement with rheological measurements performed on the same samples

Alternate proof of the Rowe-Rosensteel proposition and seniority conservation

For a system with three identical nucleons in a single-$j$ shell, the states can be written as the angular momentum coupling of a nucleon pair and the odd nucleon. The overlaps between these non-orthonormal states form a matrix which coincides with the one derived by Rowe and Rosensteel [Phys. Rev. Lett. {\bf 87}, 172501 (2001)]. The propositions they state are related to the eigenvalue problems of the matrix and dimensions of the associated subspaces. In this work, the propositions will be proven from the symmetric properties of the $6j$ symbols. Algebraic expressions for the dimension of the states, eigenenergies as well as conditions for conservation of seniority can be derived from the matrix.Comment: 9 pages, no figur