Primary neurons that express the L2/HNK-1 carbohydrate during early development in the zebrafish

In zebrafish, many nerve pathways in both the CNS and periphery are pioneered by a small and relatively simple set of ‘primary’ neurons that arise in the early embryo. We now have used monoclonal antibodies to show that, as they develop, primary neurons of several functional classes express on their surfaces the L2/HNK-1 tetrasaccharide that is associated with a variety of cell surface adhesion molecules. We have studied the early labeling patterns of these neurons, as well as some non-neural cells, and found that the time of onset and intensity of immunolabeling vary specifically according to cell type. The first neuronal expression is by Rohon-Beard and trigeminal ganglion neurons, both of which are primary sensory neurons that mediate touch sensitivity. These cells express the epitope very strongly on their growth cones and axons, permitting study of their development unobscured by labeling in other cells. Both types initiate axogenesis at the same early time, and appear to be the first neurons in the embryo to do so. Their peripheral neurites display similar branching patterns and have similar distinctive growth cone morphologies. Their central axons grow at the same rate along the same longitudinal fiber pathway, but in opposite directions, and where they meet they appear to fasciculate with one another. The similarities suggest that Rohon-Beard and trigeminal ganglion neurons, despite their different positions, share a common program of early development. Immunolabeling is also specifically present on a region of the brain surface where the newly arriving trigeminal sensory axons will enter the brain. Further, the trigeminal expression of the antigen persists in growth cones during the time that they contact an individually identified central target neuron, the Mauthner cell, which also expresses the epitope. These findings provide descriptive evidence for possible roles of L2/HNK-1 immunoreactive molecules in axonal growth and synaptogenesis

Epilogue: Superconducting Materials Past, Present and Future

Experimental contributors to the field of Superconducting Materials share their informal views on the subject.Comment: Epilogue to Physica C Special Issue on Superconducting Materials, Volume 514 (2015

Technological change and price effects in agriculture

This paper addresses the conceptual issues around the negative price effects of technological change on agricultural producers, explores price policy options vis-à-vis this problem, and reviews and compares experiences across Asian countries as they transformed their rural economies. It then draws implications for the challenge of achieving a smallholder-led agricultural revolution in Africa in the context of market liberalization.Small farmers ,technicological change ,market prices ,

High-Performance, Multi-Node File Copies and Checksums for Clustered File Systems

Modern parallel file systems achieve high performance using a variety of techniques, such as striping files across multiple disks to increase aggregate I/O bandwidth and spreading disks across multiple servers to increase aggregate interconnect bandwidth. To achieve peak performance from such systems, it is typically necessary to utilize multiple concurrent readers/writers from multiple systems to overcome various singlesystem limitations, such as number of processors and network bandwidth. The standard cp and md5sum tools of GNU coreutils found on every modern Unix/Linux system, however, utilize a single execution thread on a single CPU core of a single system, and hence cannot take full advantage of the increased performance of clustered file systems. Mcp and msum are drop-in replacements for the standard cp and md5sum programs that utilize multiple types of parallelism and other optimizations to achieve maximum copy and checksum performance on clustered file systems. Multi-threading is used to ensure that nodes are kept as busy as possible. Read/write parallelism allows individual operations of a single copy to be overlapped using asynchronous I/O. Multinode cooperation allows different nodes to take part in the same copy/checksum. Split-file processing allows multiple threads to operate concurrently on the same file. Finally, hash trees allow inherently serial checksums to be performed in parallel. Mcp and msum provide significant performance improvements over standard cp and md5sum using multiple types of parallelism and other optimizations. The total speed-ups from all improvements are significant. Mcp improves cp performance over 27x, msum improves md5sum performance almost 19x, and the combination of mcp and msum improves verified copies via cp and md5sum by almost 22x. These improvements come in the form of drop-in replacements for cp and md5sum, so are easily used and are available for download as open source software at http://mutil.sourceforge.net

Dielectric properties measurements of brown and white adipose tissue in rats from 0.5 to 10 GHz

Brown adipose tissue (BAT) plays an important role in whole body metabolism and with appropriate stimulus could potentially mediate weight gain and insulin sensitivity. Although imaging techniques are available to detect subsurface BAT, there are currently no viable methods for continuous acquisition of BAT energy expenditure. Microwave (MW) radiometry is an emerging technology that allows the quantification of tissue temperature variations at depths of several centimeters. Such temperature differentials may be correlated with variations in metabolic rate, thus providing a quantitative approach to monitor BAT metabolism. In order to optimize MW radiometry, numerical and experimental phantoms with accurate dielectric properties are required to develop and calibrate radiometric sensors. Thus, we present for the first time, the characterization of relative permittivity and electrical conductivity of brown (BAT) and white (WAT) adipose tissues in rats across the MW range 0.5-10GHz. Measurements were carried out in situ and post mortem in six female rats of approximately 200g. A Cole-Cole model was used to fit the experimental data into a parametric model that describes the variation of dielectric properties as a function of frequency. Measurements confirm that the dielectric properties of BAT (εr = 14.0-19.4, σ = 0.3-3.3S/m) are significantly higher than those of WAT (εr = 9.1-11.9, σ = 0.1-1.9S/m), in accordance with the higher water content of BAT

The transition temperature of the dilute interacting Bose gas

We show that the critical temperature of a uniform dilute Bose gas must increase linearly with the s-wave scattering length describing the repulsion between the particles. Because of infrared divergences, the magnitude of the shift cannot be obtained from perturbation theory, even in the weak coupling regime; rather, it is proportional to the size of the critical region in momentum space. By means of a self-consistent calculation of the quasiparticle spectrum at low momenta at the transition, we find an estimate of the effect in reasonable agreement with numerical simulations.Comment: 4 pages, Revtex, to be published in Physical Review Letter

Probing the mechanical properties of graphene using a corrugated elastic substrate

The exceptional mechanical properties of graphene have made it attractive for nano-mechanical devices and functional composite materials. Two key aspects of graphene's mechanical behavior are its elastic and adhesive properties. These are generally determined in separate experiments, and it is moreover typically difficult to extract parameters for adhesion. In addition, the mechanical interplay between graphene and other elastic materials has not been well studied. Here, we demonstrate a technique for studying both the elastic and adhesive properties of few-layer graphene (FLG) by placing it on deformable, micro-corrugated substrates. By measuring deformations of the composite graphene-substrate structures, and developing a related linear elasticity theory, we are able to extract information about graphene's bending rigidity, adhesion, critical stress for interlayer sliding, and sample-dependent tension. The results are relevant to graphene-based mechanical and electronic devices, and to the use of graphene in composite, flexible, and strain-engineered materials.Comment: 5 pages, 4 figure

Evaluasi Segregasi Quantitative Trait Loci (Qtl) Pada Tanaman Padi Sawah Varietas Lokal Yang Digogoorganikkan

Penelitian bertujuan untuk (1) mendapatkan entri (varietas-QTL) yang dapat bertahan di lingkungan gogo sehingga dapat direkomendasi sebagai tetua dalam perakitan padi hibrida; (2) mendapatkan entri yang memiliki ragam genetik dan heritabilitas broad-sense pada padi varietas lokal yang digogoorganikkan; dan (3) mendapat peubah yang dapat dijadikan seleksi tidak langsung yang berpengaruh terhadap seleksi langsung (produksi). Penelitian dilaksanakan pada bulan Desember 2012-April 2013 di Politeknik Negeri Lampung dan Laboratorium Benih, Fakultas Pertanian, Universitas Lampung.Rancangan perlakuan disusun berdasarkan kuasi RTS (Rancangan Teracak Sempurna) karena dalam penelitian ini tidak memungkinkan untuk dilakukan pengulangan kelompok sehingga, ulangan berada di dalam kelompok.Masing-masing kelompok diambil 9 sampel tanaman yang dibagi menjadi 3 ulangan, dan setiap ulangan terdiri dari 3 tanaman.Sebelum dianalisis ragam, rerata pengamatn masingmasing variabel diuji Bartlett dan Levene untuk kehomogenan ragam. Bila hasil analisis ragam nyata pada P <0,01 atau 0,05 maka, dilakukan pemeringkatan nilai tengah dengan Beda Nyata Jujur (BNJ). Seluruh statistika data menggunakan software Statistic Analysis System (SAS) 9.1 for Windows.Besarnya ragam genetik dan heritabilitas broad-sense diduga berdasarkan kuadrat nilai tengah harapan pada hasil analisis ragam.Hasil penelitian menunjukkan bahwa (1) PB Bogor-tinggi tanaman (801,50g/m2) Kesit-tinggi tanaman (546,77 g/m2) dan Tewe-jumlah anakan (487,57 g/m) mampu bertahan di lingkungan gogoorganik sehingga, dapat direkomendasi sebagai tetua dalam perakitan padi hibrida; (2) semua peubah yang diamati mampu memberikan perbedaan ragam genetik dan heritabilitas broad-sense; dan (3) karakter jumlah anakan total dapat dijadikan seleksi tidak langsung yang dapat meningkatkan hasil produksi

Reduced Gutzwiller formula with symmetry: case of a finite group

We consider a classical Hamiltonian $H$ on $\mathbb{R}^{2d}$, invariant by a finite group of symmetry $G$, whose Weyl quantization $\hat{H}$ is a selfadjoint operator on $L^2(\mathbb{R}^d)$. If $\chi$ is an irreducible character of $G$, we investigate the spectrum of its restriction $\hat{H}\_\chi$ to the symmetry subspace $L^2\_\chi(\mathbb{R}^d)$ of $L^2(\mathbb{R}^d)$ coming from the decomposition of Peter-Weyl. We give reduced semi-classical asymptotics of a regularised spectral density describing the spectrum of $\hat{H}\_\chi$ near a non critical energy $E\in\mathbb{R}$. If $\Sigma\_E:=\{H=E \}$ is compact, assuming that periodic orbits are non-degenerate in $\Sigma\_E/G$, we get a reduced Gutzwiller trace formula which makes periodic orbits of the reduced space $\Sigma\_E/G$ appear. The method is based upon the use of coherent states, whose propagation was given in the work of M. Combescure and D. Robert.Comment: 20 page

Phenomenology of A Three-Family Standard-like String Model

We discuss the phenomenology of a three-family supersymmetric Standard-like Model derived from the orientifold construction, in which the ordinary chiral states are localized at the intersection of branes at angles. In addition to the Standard Model group, there are two additional U(1)' symmetries, one of which has family non-universal and therefore flavor changing couplings, and a quasi-hidden non-abelian sector which becomes strongly coupled above the electroweak scale. The perturbative spectrum contains a fourth family of exotic (SU(2)- singlet) quarks and leptons, in which, however, the left-chiral states have unphysical electric charges. It is argued that these decouple from the low energy spectrum due to hidden sector charge confinement, and that anomaly matching requires the physical left-chiral states to be composites. The model has multiple Higgs doublets and additional exotic states. The moduli-dependent predictions for the gauge couplings are discussed. The strong coupling agrees with experiment for reasonable moduli, but the electroweak couplings are too small.Comment: 22 pages, 4 figure