Phase of beta-frequency tACS over primary motor cortex modulates corticospinal excitability

The assessment of corticospinal excitability by means of transcranial magnetic stimulation-induced motor evoked potentials is an established diagnostic tool in neurophysiology and a widely used procedure in fundamental brain research. However, concern about low reliability of these measures has grown recently. One possible cause of high variability of MEPs under identical acquisition conditions could be the influence of oscillatory neuronal activity on corticospinal excitability. Based on research showing that transcranial alternating current stimulation can entrain neuronal oscillations we here test whether alpha or beta frequency tACS can influence corticospinal excitability in a phase-dependent manner. We applied tACS at individually calibrated alpha- and beta-band oscillation frequencies, or we applied sham tACS. Simultaneous single TMS pulses time locked to eight equidistant phases of the ongoing tACS signal evoked MEPs. To evaluate offline effects of stimulation frequency, MEP amplitudes were measured before and after tACS. To evaluate whether tACS influences MEP amplitude, we fitted one-cycle sinusoids to the average MEPs elicited at the different phase conditions of each tACS frequency. We found no frequency-specific offline effects of tACS. However, beta-frequency tACS modulation of MEPs was phase-dependent. Post hoc analyses suggested that this effect was specific to participants with low (<19 Hz) intrinsic beta frequency. In conclusion, by showing that beta tACS influences MEP amplitude in a phase-dependent manner, our results support a potential role attributed to neuronal oscillations in regulating corticospinal excitability. Moreover, our findings may be useful for the development of TMS protocols that improve the reliability of MEPs as a meaningful tool for research applications or for clinical monitoring and diagnosis. (C) 2018 Elsevier Ltd. All rights reserved

Super Stability of Laminar Vortex Flow in Superfluid 3He-B

Vortex flow remains laminar up to large Reynolds numbers (Re~1000) in a cylinder filled with 3He-B. This is inferred from NMR measurements and numerical vortex filament calculations where we study the spin up and spin down responses of the superfluid component, after a sudden change in rotation velocity. In normal fluids and in superfluid 4He these responses are turbulent. In 3He-B the vortex core radius is much larger which reduces both surface pinning and vortex reconnections, the phenomena, which enhance vortex bending and the creation of turbulent tangles. Thus the origin for the greater stability of vortex flow in 3He-B is a quantum phenomenon. Only large flow perturbations are found to make the responses turbulent, such as the walls of a cubic container or the presence of invasive measuring probes inside the container.Comment: 4 pages, 6 figure

Analyse du risque posé en santé animale par la présence de l'hydroxyméthylfurfural dans les sirops de nourrissement des abeilles domestiques

This paper discusses an incident that occurred in Belgium during winter 2009-2010, after which many honey bee colonies have been lost. Later analyses showed that these colonies had been fed during the winter with a inverted sugar syrup from sugar beet which had a high concentration of hydroxymethylfurfural (HMF). HMF concentrations ranged from 18.8 ppm to 365.6 ppm. Data from the scientific literature are quite limited, but several authors confirm the harmful effect of HMF on honey bee health. Other elements, however, may have played a role in this apparent mortality such as crystallization of syrups, resulting in unavailability of sugar for the honey bees, and thus the death of them from starvation. Pending the acquisition of new scientific knowledge on the subject, it is recommended to follow good beekeeping practices detailed in this article to minimize the formation of HMF in syrups for honey bee feeding. In addition, a draft action limit corresponding to a maximal concentration of 40 ppm of HMF is proposed in order to control the risk at the producer and distributor of syrups for honey bee feeding level

Propagation of thermal excitations in a cluster of vortices in superfluid 3He-B

We describe the first measurement on Andreev scattering of thermal excitations from a vortex configuration with known density, spatial extent, and orientations in 3He-B superfluid. The heat flow from a blackbody radiator in equilibrium rotation at constant angular velocity is measured with two quartz tuning fork oscillators. One oscillator creates a controllable density of excitations at 0.2Tc base temperature and the other records the thermal response. The results are compared to numerical calculations of ballistic propagation of thermal quasiparticles through a cluster of rectilinear vortices.Comment: 6 pages, 4 figure

Vortex core contribution to textural energy in 3He-B below 0.4Tc

Vortex lines affect the spatial order-parameter distribution in superfluid 3He-B owing to superflow circulating around vortex cores and due to the interaction of the order parameter in the core and in the bulk as a result of superfluid coherence over the whole volume. The step-like change of the latter contribution at 0.6Tc (at a pressure of 29bar) signifies the transition from axisymmetric cores at higher temperatures to broken-symmetry cores at lower temperatures. We extended earlier measurements of the core contribution to temperatures below 0.2Tc, in particular searching for a possible new core transition to lower symmetries. As a measuring tool we track the energy levels of magnon condensate states in a trap formed by the order-parameter texture.Comment: 13 pages, 10 figures, submitted to proceedings of the QFS2010 conferenc

Experimental determination of the quasi-particle decay length ξSm\xi_{\text{Sm}} in a superconducting quantum well

We have investigated experimentally the electronic transport properties of a two-dimensional electron gas (2DEG) present in an AlSb/InAs/AlSb quantum well, where part of the toplayer has been replaced by a superconducting Nb strip, with an energy gap $\Delta_0$. By measuring the lateral electronic transport underneath the superconductor, and comparing the experimental results with a model based on the Bogoliubov-de Gennes equation and the Landauer-B\"uttiker formalism, we obtain a decay length $\xi_{\text{Sm}} \approx 100~\text{nm}$ for electrons. This decay length corresponds to an interface transparency $T_{\text{SIN}}=0.7$ between the Nb and InAs. Using this value, we infer an energy gap in the excitation spectrum of the SQW of $\Delta_{\text{eff}} = 0.97 \Delta_0 = 0.83~\text{meV}$.Comment: Revtex, 3 PostScript figure

Superfluid vortex front at T -> 0: Decoupling from the reference frame

Steady-state turbulent motion is created in superfluid 3He-B at low temperatures in the form of a turbulent vortex front, which moves axially along a rotating cylindrical container of 3He-B and replaces vortex-free flow with vortex lines at constant density. We present the first measurements on the thermal signal from dissipation as a function of time, recorded at 0.2 Tc during the front motion, which is monitored using NMR techniques. Both the measurements and the numerical calculations of the vortex dynamics show that at low temperatures the density of the propagating vortices falls well below the equilibrium value, i.e. the superfluid rotates at a smaller angular velocity than the container. This is the first evidence for the decoupling of the superfluid from the container reference frame in the zero-temperature limit.Comment: 4 pages, 4 figure

Spontaneous Charging and Crystallization of Water Droplets in Oil

We study the spontaneous charging and the crystallization of spherical micron-sized water-droplets dispersed in oil by numerically solving, within a Poisson-Boltzmann theory in the geometry of a spherical cell, for the density profiles of the cations and anions in the system. We take into account screening, ionic Born self-energy differences between oil and water, and partitioning of ions over the two media. We find that the surface charge density of the droplet as induced by the ion partitioning is significantly affected by the droplet curvature and by the finite density of the droplets. We also find that the salt concentration and the dielectric constant regime in which crystallization of the water droplets is predicted is enhanced substantially compared to results based on the planar oil-water interface, thereby improving quantitative agreement with recent experiments.Comment: 10 pages, 7 figures, submitted for publicatio

Dynamic Remanent Vortices in Superfluid 3He-B

We investigate the decay of vortices in a rotating cylindrical sample of 3He-B, after rotation has been stopped. With decreasing temperature vortex annihilation slows down as the damping in vortex motion, the mutual friction dissipation \alpha(T), decreases almost exponentially. Remanent vortices then survive for increasingly long periods, while they move towards annihilation in zero applied flow. After a waiting period \Delta t at zero flow, rotation is reapplied and the remnants evolve to rectilinear vortices. By counting these lines, we measure at temperatures above the transition to turbulence ~0.6T_c the number of remnants as a function of \alpha(T) and \Delta t. At temperatures below the transition to turbulence T \lesssim 0.55 T_c, remnants expanding in applied flow become unstable and generate in a turbulent burst the equilibrium number of vortices. Here we measure the onset temperature T_on of turbulence as a function of \Delta t, applied flow velocity, and length of sample L.Comment: Submitted to the proceedings of the Quantum Fluids and Solids Conference 2006 (to be published in Journal of Low Temperature Physics 2007) New data are adde

Amblyopia and quality of life: a systematic review

Background/Aims Amblyopia is a common condition which can affect up to 5% of the general population. The health-related quality of life (HRQoL) implications of amblyopia and/or its treatment have been explored in the literature. Methods A systematic literature search was undertaken (16th-30th January 2007) to identify the HRQoL implications of amblyopia and/or its treatment. Results A total of 25 papers were included in the literature review. The HRQoL implications of amblyopia related specifically to amblyopia treatment, rather than the condition itself. These included the impact upon family life; social interactions; difficulties undertaking daily activities; and feelings and behaviour. The identified studies adopted a number of methodologies. The study populations included; children with the condition; parents of children with amblyopia; and adults who had undertaken amblyopia treatment as a child. Some studies developed their own measures of HRQoL, and others determined HRQoL through proxy measures. Conclusions The reported findings of the HRQoL implications are of importance when considering the management of cases of amblyopia. Further research is required to assess the immediate and long-term effects of amblyopia and/or its treatment upon HRQoL using a more standardised approach