4,946 research outputs found

    How should we supervise qualitative projects?

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    There is a ‘shortfall in numbers of highly skilled qualitative researchers’ says the Economic and Social Research Council (2004). What is psychology doing about it? The Society’s revised syllabus (BPS, 2002) states that students should be able to collect and analyse qualitative (non-numerical) data. The Quality Assessment Agency (QAA, 2002) also specifies that psychology should cover qualitative methods. Therefore, in time, psychology graduates should have the expertise the ESRC needs

    Non-existence of normal tokamak equilibria with negative central current

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    Recent tokamak experiments employing off-axis, non-inductive current drive have found that a large central current hole can be produced. The current density is measured to be approximately zero in this region, though in principle there was sufficient current drive power for the central current density to have gone significantly negative. Recent papers have used a large aspect-ratio expansion to show that normal MHD equilibria (with axisymmetric nested flux surfaces, non-singular fields, and monotonic peaked pressure profiles) can not exist with negative central current. We extend that proof here to arbitrary aspect ratio, using a variant of the virial theorem to derive a relatively simple integral constraint on the equilibrium. However, this constraint does not, by itself, exclude equilibria with non-nested flux surfaces, or equilibria with singular fields and/or hollow pressure profiles that may be spontaneously generated.Comment: 5 pages, 3 figures. Submitted to Physics of Plasmas, Feb. 14, 2003. Revised Feb. 24, 2003. Vers. 2: revised May 29 to clarify points raised by referee, add references to recent work. July 18, accepted for publicatio

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    A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis.

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    In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of disabling symptoms. Myocardin Related Transcription Factor-A (MRTF-A) is a transcriptional co-activator that is sequestered in the cytoplasm and translocates to the nucleus under mechanical stress or growth factor stimulation. Our objective was to determine if MRTF-A is activated in the disease microenvironment to produce more extracellular matrix in progressive SSc. Immunohistochemistry studies demonstrate that nuclear translocation of MRTF-A in scleroderma tissues occurs in keratinocytes, endothelial cells, infiltrating inflammatory cells, and dermal fibroblasts, consistent with enhanced signaling in multiple cell lineages exposed to the stiff extracellular matrix. Inhibition of MRTF-A nuclear translocation or knockdown of MRTF-A synthesis abolishes the SSc myofibroblast enhanced basal contractility and synthesis of type I collagen and inhibits the matricellular profibrotic protein, connective tissue growth factor (CCN2/CTGF). In MRTF-A null mice, basal skin and lung stiffness was abnormally reduced and associated with altered fibrillar collagen. MRTF-A has a role in SSc fibrosis acting as a central regulator linking mechanical cues to adverse remodeling of the extracellular matrix

    Microscopic dynamics of thin hard rods

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    Based on the collision rules for hard needles we derive a hydrodynamic equation that determines the coupled translational and rotational dynamics of a tagged thin rod in an ensemble of identical rods. Specifically, based on a Pseudo-Liouville operator for binary collisions between rods, the Mori-Zwanzig projection formalism is used to derive a continued fraction representation for the correlation function of the tagged particle's density, specifying its position and orientation. Truncation of the continued fraction gives rise to a generalised Enskog equation, which can be compared to the phenomenological Perrin equation for anisotropic diffusion. Only for sufficiently large density do we observe anisotropic diffusion, as indicated by an anisotropic mean square displacement, growing linearly with time. For lower densities, the Perrin equation is shown to be an insufficient hydrodynamic description for hard needles interacting via binary collisions. We compare our results to simulations and find excellent quantitative agreement for low densities and qualtitative agreement for higher densities.Comment: 21 pages, 6 figures, v2: clarifications and improved readabilit

    A single structured light beam as an atomic cloud splitter

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    We propose a scheme to split a cloud of cold non-interacting neutral atoms based on their dipole interaction with a single structured light beam which exhibits parabolic cylindrical symmetry. Using semiclassical numerical simulations, we establish a direct relationship between the general properties of the light beam and the relevant geometric and kinematic properties acquired by the atomic cloud as its passes through the beam.Comment: 10 pages, 5 figure

    Developing and testing a strategy to enhance a palliative approach and care continuity for people who have dementia: Study overview and protocol

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    Background: Typically, dementia involves progressive cognitive and functional deterioration, leading to death. A palliative approach recognizes the inevitable health decline, focusing on quality of life. The approach is holistic, proactive, supports the client and the family, and can be provided by the client’s usual care team. In the last months of life, distressing symptoms, support needs, and care transitions may escalate. This project trialed a strategy intended to support a consistent, high quality, palliative approach for people with dementia drawing close to death. The strategy was to implement two communities of practice, drawn primarily from service provider organizations across care sectors, supporting them to address practice change. Communities comprised practitioners and other health professionals with a passionate commitment to dementia palliative care and the capacity to drive practice enhancement within partnering organizations. Project aims were to document: (i) changes driven by the communities of practice; (ii) changes in staff/practitioner characteristics during the study (knowledge of a palliative approach and dementia; confidence delivering palliative care; views on death and dying, palliative care, and a palliative approach for dementia); (iii) outcomes from perspectives of family carers, care providers, and community of practice members; (iv) the extent to which changes enhanced practice and care continuity; and (v) barriers to and facilitators of successful community of practice implementation. Methods/design: This action research project was implemented over 14 months in 2010/11 in metropolitan Perth, Western Australia and regional Launceston, Tasmania. Each state based community of practice worked with the researchers to scope existing practice and its outcomes. The research team compiled a report of existing practice recommendations and resources. Findings of these two steps informed community of practice action plans and development of additional resources. Change implementation was recorded and explored in interviews, comparisons being made with practice recommendations. Changes in staff/practitioner characteristics were evaluated using survey data. Findings from semi structured interviews and survey administration established outcomes from perspectives of family carers, care providers, and community of practice members. Consideration of processes and outcomes, across the two state based settings, informed identification of barriers and facilitators. Community of practice reflections also informed study recommendations

    Casimir Energy of a Spherical Shell

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    The Casimir energy for a conducting spherical shell of radius aa is computed using a direct mode summation approach. An essential ingredient is the implementation of a recently proposed method based on Cauchy's theorem for an evaluation of the eigenfrequencies of the system. It is shown, however, that this earlier calculation uses an improper set of modes to describe the waves exterior to the sphere. Upon making the necessary corrections and taking care to ensure that no mathematically ill-defined expressions occur, the technique is shown to leave numerical results unaltered while avoiding a longstanding criticism raised against earlier calculations of the Casimir energy.Comment: LaTeX, 14 pages, 1 figur

    Modeling the Spatially Varying Water Balance Processes in a Semi- Arid Mountainous Watershed of Idaho

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    Mountainous watersheds in semi-arid regions are complex hydrologic systems. To critically evaluate the hydrological processes, high resolution spatio-temporal information is necessary. Also, calibrating and validating a watershed-scale model is necessary to enable our understanding of the water balance components in the gauged watersheds. The distributed Soil Water Assessment Tool (SWAT) hydrologic model was applied to a research watershed, the Dry Creek Experimental Watershed (DCEW), near Boise Idaho to investigate its water balance components both temporally and spatially. Daily streamflow data from four streamflow gauges were used for calibration and validation of the model. Monthly estimates of streamflow during the calibration phase by SWAT produced satisfactory results with a Nash Sutcliffe coefficient of model efficiency 0.79. Since it is a continuous simulation model, as opposed to an event-based model, it demonstrated the limited ability in capturing both streamflow and soil moisture for selected rain-on-snow events during the validation period between 2005-07. Our implementation of SWAT showed that seasonal and annual water balance partitioning of precipitation into evapotranspiration, streamflow, soil moisture and drainage was not only possible but closely followed the trends of a typical semiarid watershed in the intermountain west. This study highlights the necessity for better techniques to precisely identify and drive the model with commonly observed climatic inversion-related snowmelt or rain-on-snow weather events. Estimation of key parameters pertaining to soil (e.g., available water content and saturated hydraulic conductivity), snow (e.g., lapse rates, melting) and vegetation (e.g., leaf area index and maximum canopy index) using additional field observations in the watershed is critical for better prediction
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