Splenic hemangiosarcoma with abdominal dissemination in a dog

A case of spontaneosly ruptured splenic hemangiosarcoma with abdominal dissemination in a 12-year-old male German shepherd dog is described. At necropsy, a ruptured tumor mass was seen in the ventral region of the Visceral surface of the spleen, and disseminated tumor masses were seen throughout the peritoneal cavity. Histologically, in both the primary tumor mass and disseminated tumor masses, atypical endothelial cells lining vascular spaces as small clefts or as cavernous channels were observed. Some immunological properties of tumor cells were determined for endothelial cell markers (factor VII-related antigen=von Willebrand's factor [vWf] and CD31 antigen), mesenchymal tissue marker (vimentin) and pericyte-smooth muscle marker (a-smooth muscle actin [alpha-SMA]). Tumor cells were positive for CD31, vimentin and a-SMA, whereas they were negative for vWf. According to morphological and immunohistochemical results, this case was diagnosed as hemangiosarcoma arising from the spleen with abdominal dissemination

Ventral fixation in atlantoaxial instability with axial fracture in a dog

SummaryThis study reports the diagnosis and the surgical management of atlanto-axial instability with an oblique axial fracture in a dog. The fracture was diagnosed by radiography and Computed Tomography (CT). In the CT views, the appearance of the distortion of the atlantoaxial articular surface was interpreted as instability. The stabilization was achieved with the cancellous screws. Following the surgery, the neurological status improved and the dog no longer had marked neurological deficits.</jats:p

The Effect of Chronic Otitis Externa-Media on Brainstem Auditory Evoked Potentials in Dogs

WOS: 000263226200018The objective of the study was to present normative Brainstem Auditory Evoked Potentials (BAEP) data elicited by both air-conducted clicks (30 100 dBHL) and bone conducted clicks (100 1.30 dBHL) for healthy dogs, and dogs with chronic otitis externa-media (COEM). The data were analyzed to acquire reference values in 55 normal dogs and to estimate the degree of hearing, impairment associated with the disease. Filly-four dogs with COLM were divided into two degrees of security. The first one included dogs with severe (n 16), and the second with moderate COFM (n 38). The recognisability wave V was found higher than the others at every stimulation level. Wave VII was not seen by the bone-conducted click at all stimulation levels. and also in cases with severe COLM by the air.-conducted click. Recognisability of wave V was seen more than 50%, at 60 dBHL in severe COEM. This ratio was seen at 30 dBHL in moderate COLM. In healthy dogs, the latencies of waves (I VII) were compared between the left and the right side, and there were no significant differences between each side except tiff I shorter latency of wave VI. In conclusion, COEM caused increasing latency rather than total deafness, and BAFP can be suggested as an ancillary diagnostic tool in car disorders.TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [VHAG 2003]This study was supported by TUBITAK as VHAG 2003

Magnetic resonance imaging findings in dogs with thoracolumbar intervertebral disk disease: 69 cases (1997-2005)

Besalti, Omer/0000-0002-7819-9094;WOS: 000235977300025PubMed: 16536704Objective-To determine magnetic resonance imaging (MRI) abnormalities in dogs with intervertebral disk disease (IVDD) and develop a classification scheme for IVDD in dogs based on MRI findings. Design-Retrospective case series. Animals-69 dogs. Procedure-Medical records of dogs admitted because of thoracolumbar IVDD in which MRI of T9 through L7 had been performed were reviewed. Results-A total of 759 intervertebral disk spaces were examined. Of these, 342 (45.1%) were classified as having a normal MRI appearance; the remaining 417 (54.9%) had various types of IVDD. Disk degeneration was identified in 276 disk spaces in 56 dogs, bulging of the intervertebral disk was identified in 37 disk spaces in 24 dogs, disk protrusion was identified in 54 disk spaces in 32 dogs, and disk extrusion was identified in 50 disk spaces in 48 dogs. Cartilage endplate changes were identified in 35 vertebrae in 17 dogs, and increased signal intensity of the spinal cord was identified in 21 dogs. Conclusions and Clinical Relevance-Four types of IVDD (disk degeneration, bulging of the intervertebral disk, disk protrusion, and disk extrusion) were identified on the basis of MRI findings in dogs with thoracolumbar IVDD. We recommend that a standardized nomenclature be adopted for the various types of thoracolumbar IVDD in dogs

Comparative study of discolysis and disc fenestration in dogs

Postoperative clinical, histopathological and radiological findings were evaluated for disc fenestration, open discolysis (chymopapain) and percutan discolysis which had been performed on three groups of dogs, each group containing 6 healthy mongrels of different ages, sexes and breeds. The degrees of intervertebral space narrowing were classified as mild, medium and severe according to postoperative radiological examinations. Sections which were prepared from intervertebral areas which had been operated on, were investigated histopathologically, It was considered that discolysis might be cost effective on type-2 disc diseases, cases without advanced paralysis and cases requiring prophylactic disc fenestration, According to clinical examination results neurological disorders were not observed in the groups with disc fenestration or discolysis. Radiological and hisyopathological findings with respect to disc fenestration were more uniform than in the group which had undergone discolysis

The evaluation of renal allo and autotransplantation results in cats

WOS: 000180152200023For the first time in Turkey, renal autotransplantation in 7 cats and renal allotransplantation in 7 cats having blood-crossmatch-compatible donors were performed. Immunosuppression was maintained by a prednisolone-cyclosporin combination in the renal allotransplantation group. All cats in the renal allotransplantation group died during the operation or between 3 and 72 h postoperatively. Two cats in the renal autotransplantation group survived approximately 2 years. Hyperacute or acute rejection findings were not encountered according to perioperative observations, laboratory findings or histopathological evaluations of renal allografts. The results of histopathological evaluations of renal allografts indicated acute tubular necrosis (ATN) findings caused by renal hypoperfusion due to hypotension. The reason for ATN was considered to be a result of hypotension that invasive methods could not control

Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage

Background. Though cerebral vasospasm is one of the most serious complications of subarachnoid haemorrhage (SAH), its complex pathogenesis is poorly understood and available clinical treatment options are unsatisfactory. This study was designed to examine the efficacy of leflunomide, an immunomodulatory agent with inhibitory properties, on vascular smooth muscle cell proliferation and inflammation in a rabbit cerebral vasospasm model