Lawson criterion for ignition exceeded in an inertial fusion experiment

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion

Impact of Systemic Inflammation and Autoimmune Diseases on apoA-I and HDL Plasma Levels and Functions

The cholesterol of high-density lipoproteins (HDLs) and its major proteic component, apoA-I, have been widely investigated as potential predictors of acute cardiovascular (CV) events. In particular, HDL cholesterol levels were shown to be inversely and independently associated with the risk of acute CV diseases in different patient populations, including autoimmune and chronic inflammatory disorders. Some relevant and direct anti-inflammatory activities of HDL have been also recently identified targeting both immune and vascular cell subsets. These studies recently highlighted the improvement of HDL function (instead of circulating levels) as a promising treatment strategy to reduce inflammation and associated CV risk in several diseases, such as systemic lupus erythematosus and rheumatoid arthritis. In these diseases, anti-inflammatory treatments targeting HDL function might improve both disease activity and CV risk. In this narrative review, we will focus on the pathophysiological relevance of HDL and apoA-I levels/functions in different acute and chronic inflammatory pathophysiological conditions

Alternate H2 Sinks for reducing rumen methanogenesis

Greenhouse gas (GHG) emissions from livestock is about 7,516 million metric tons CO2-eq.year-1and has multiple components that include enteric methane emissions, methane and nitrous oxide emissions from manure and carbon dioxide emissions associated with feed production and grazing. An uninterruptedly increasing concentration (155 % more than preindustrial level), a comparatively high global warming potential and a short half-life of methane make it a bit more important than any other GHG in the control of global warming and climate change. Enteric methane mitigation is not only important from a global warming point but also for saving animal dietary energy which is otherwise lost in the form of methane. Due to the central regulatory role of H2, it is generally referred as the currency of fermentation and most of the mitigation strategies revolve around its production or disposal in such a way as to ensure the conservation of energy into desirable end products. In the chapter, an attempt is made to address the prospects of some emerging approaches to redirect metabolic H2away from methanogenesis and serve as potential alternate sink for H2in the rumen for conserving energy. The prospects of alternate sinks, for instance, sulphate and nitrate reduction and reductive acetogenesis and propionogenesis, are debated in the chapter along with the anticipated benefits that can be achieved from the practically feasible 20 % enteric methane reduction