9 research outputs found
The knowledge, attitudes and perceptions of healthcare students and professionals regarding the interdisciplinary health worker team at Stelenbosch University and Tygerberg Academic Hospital
Geneeskunde en GesondheidswetenskappeMenslike VoedingPlease help us populate SUNScholar with the post print version of this article. It can be e-mailed to: [email protected]
Impact of defoliation severity on photosynthesis, carbon metabolism and transport gene expression in perennial ryegrass
Alternative approaches to constructing composite indicators: an application to construct a Sustainable Energy Index for APEC economies
Trusting the Coalface: Public Trust in South African Local Government and the Millennium Development Goals
Prevalence and unmet need for diabetes care across the care continuum in a national sample of South African adults: Evidence from the SANHANES-1, 2011-2012
Spirituality and leadership in a South African context
Abstract: This chapter discusses spirituality and leadership in a South African context. Leadership theories that are situated in the spiritual paradigm such as authentic, servant, spiritual and transformational leadership are considered in this chapter. It is argued that leadership practices and styles in South Africa are heavily influenced by British and American approaches. The notion of “ubuntu,” which is a central component of Afrocentric leadership is thus largely ignored in literature on the topic. This chapter draws attention to the influence of Western approaches on leadership in South African organisations with particular reference to the Afrocentric notion of ubuntu. It is recommended that further research be undertaken on ubuntu leadership in the South African context and beyond. Another recommendation is that research should be undertaken on blending Afrocentric and Eurocentric leadership styles in order to identify how this combined leadership approach can be implemented in South Africa
Measuring Progress: A Comparison of the GDP, HDI, GS and the RIE
Measurement, Progress, Aggregation, Weighting,
An Exploration of Human Well-Being Bundles as Identifiers of Ecosystem Service Use Patterns
Liraglutide and Renal Outcomes in Type 2 Diabetes.
BACKGROUND:
In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown.
METHODS:
We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease. The risk of renal outcomes was determined with the use of time-to-event analyses with an intention-to-treat approach. Changes in the estimated glomerular filtration rate and albuminuria were also analyzed.
RESULTS:
A total of 9340 patients underwent randomization, and the median follow-up of the patients was 3.84 years. The renal outcome occurred in fewer participants in the liraglutide group than in the placebo group (268 of 4668 patients vs. 337 of 4672; hazard ratio, 0.78; 95% confidence interval [CI], 0.67 to 0.92; P=0.003). This result was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer participants in the liraglutide group than in the placebo group (161 vs. 215 patients; hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P=0.004). The rates of renal adverse events were similar in the liraglutide group and the placebo group (15.1 events and 16.5 events per 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years, respectively).
CONCLUSIONS:
This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .)
