A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease Study 2021

Background Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets for disease mitigation. We describe the prevalence, years lived with disability, and trends of anaemia and its underlying causes in 204 countries and territories. Methods We estimated population-level distributions of haemoglobin concentration by age and sex for each location from 1990 to 2021. We then calculated anaemia burden by severity and associated years lived with disability (YLDs). With data on prevalence of the causes of anaemia and associated cause-specific shifts in haemoglobin concentrations, we modelled the proportion of anaemia attributed to 37 underlying causes for all locations, years, and demographics in the Global Burden of Disease Study 2021. Findings In 2021, the global prevalence of anaemia across all ages was 24·3% (95% uncertainty interval [UI] 23·9–24·7), corresponding to 1·92 billion (1·89–1·95) prevalent cases, compared with a prevalence of 28·2% (27·8–28·5) and 1·50 billion (1·48–1·52) prevalent cases in 1990. Large variations were observed in anaemia burden by age, sex, and geography, with children younger than 5 years, women, and countries in sub-Saharan Africa and south Asia being particularly affected. Anaemia caused 52·0 million (35·1–75·1) YLDs in 2021, and the YLD rate due to anaemia declined with increasing Socio-demographic Index. The most common causes of anaemia YLDs in 2021 were dietary iron deficiency (cause-specific anaemia YLD rate per 100 000 population: 422·4 [95% UI 286·1–612·9]), haemoglobinopathies and haemolytic anaemias (89·0 [58·2–123·7]), and other neglected tropical diseases (36·3 [24·4–52·8]), collectively accounting for 84·7% (84·1–85·2) of anaemia YLDs. Interpretation Anaemia remains a substantial global health challenge, with persistent disparities according to age, sex, and geography. Estimates of cause-specific anaemia burden can be used to design locally relevant health interventions aimed at improving anaemia management and prevention. Funding Bill & Melinda Gates Foundation

Virtual delivery of Go4Life® resources: A pilot study enhancing physical activity in older adults through pre- and post-intervention evaluation

The increase in life expectancy and prevalent inactivity linked to aging and concurrent health issues emphasize the need for accessible, regular motivational interventions in the era of mHealth. In this pre-post intervention study of adults aged 50 and older, we customized the high-quality, publicly available Go4Life® resources from the National Institute of Aging (NIA) to create automated motivational text messages with video clips, and periodic questionnaires. Twenty subjects received brief education on exercise benefits, along with weekly automated text messages, questionnaires, and feedback via the Dialog Health platform. Participants were followed weekly for 3 months. Primary outcomes included physical activity (PA) frequency, level, and duration pre-and post-intervention. Secondary outcomes included weekly changes in activity level developed from the NIA's Track your activity sheets and RAND 36-Item Short Form Survey Instrument (SF-36) questionnaires. The Generalized Estimating Equation with ordinal data is employed to find the average change in PA over 12 weeks. Only 13 subjects completed both the pre & post-surveys. The mean age was 61 years (age range of 50–73 years), and the mean BMI (range: 21.45–42.69) was 30.5; 55 % were females and 45 % males. Our study showed a statistically significant increase in the frequency of strengthening (mean = 1.23 (SD = 0.44) pre-intervention and mean = 2.08 (SD = 0.95) post-intervention, p = 0.02) and balancing ((mean = 1.31 (SD = 0.48) pre-intervention and mean = 2.31 (SD = 1.11) post-intervention, p = 0.02) exercises post intervention. No significant difference in responses to SF-36 questionnaires pre-and post-intervention. A larger study is warranted to determine further the effectiveness of periodic virtually delivered Go4life® resources to increase PA among older adults