A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

The pigmented life of a redhead.

As a redhead I have had a personal interest in red hair, freckles and sunburns since childhood. An observation of a formaldehyde-induced fluorescence in human epidermal melanocytes initiated my scientific interest in these cells. Prota and Nicolaus demonstrated that oxidation products of cysteinyldopas are the main components of pheomelanin. Our identification of 5-S-cysteinyldopa as the source of formaldehyde-induced fluorescence of normal and pathological melanocytes started a series of investigations into this amino acid, enzymatic and non-enzymatic oxidation of catecholic compounds and the metabolism of thiols. All melanocytes with functioning tyrosinase produce cysteinyldopas and the levels of 5-S-cysteinyldopa in serum and urine are related to the size and pigment forming activity of the melanocyte population. The determination of 5-S-cysteinyldopa in serum or urine is a sensitive diagnostic method in the detection of melanoma metastasis. Some non-specific formation of cysteinyldopa is present in the body, as demonstrated by 5-S-cysteinyldopa in individuals with tyrosinase-negative albinism

Using Agent-Based Modelling to Inform Policy – What Could Possibly Go Wrong?

© 2019, Springer Nature Switzerland AG. Scientific modelling can make things worse, as in the case of the North Atlantic Cod Fisheries Collapse. Some of these failures have been attributed to the simplicity of the models used compared to what they are trying to model. MultiAgent-Based Simulation (MABS) pushes the boundaries of what can be simulated, prompting many to assume that it can usefully inform policy, even in the face of complexity. That said, MABS also brings with it new difficulties and potential confusions. This paper surveys some of the pitfalls that can arise when MABS analysts try to do this. Researchers who claim (or imply) that MABS can reliably predict are criticised in particular. However, an alternative is suggested – that of using MABS for a kind of uncertainty analysis – identifying some of the possible ways a policy can go wrong (or indeed go right). A fisheries example is given. This alternative may widen, rather than narrow, the range of evidence and possibilities that are considered, which could enrich the policy-making process. We call this Reflexive Possibilistic Modelling