Globalization - the challenge of new times

The world economy undergoes through big changes and enters into the restructuring and reorganization process, which bring some countries into the new situations and faces them and their enterprises with new tasks. Knowledge has primary role, both for the individual and overall economy in this changing world, while the land, work and capital become of secondary importance. Creation and innovation enter into the way of production as its most important parts. Globalization brought by the scientific-technological revolution radically change the picture of the world, being result of increase of inter-relations in technololgical progress, which is especially important for the countries that are developing on information technologies. Globalization process is usually linked to the market, financial system, competition and corporate strategy. The globalization process enables and stimulates the removal of custom and non-custom barriers and deregulation of market expansion, what results with accelerated increase of supply, stabilization and often with decrease of prices. Such effect is determined as "supply shock", what means that the demand is in upturn by increase of supply and pressure on prices, opening the room to the enterprises for increase of production and turnover and simultaneously stimulates the adjustment to the changed market terms and qualification for European and world competition. Meanwhile, in order to realize such globalization process, it would be necessary to coordinate the macroeconomic context and economic policies of individual countries, which have been reducing macroeconomic limitatiosn and open room for global movements. As a result of coordination of macroeconomic contexts, the global economic regions on regional basis are being formed, while the customs, monetary and fiscal systems have the central place as result of coordination of macroeconomic policies and macroeconimic coordination, out of them the monetary, customs and foreign exchange rate policies being in the function of the economy stabilization and achievemnt of the high economic growth rates. Since globalization has the large impact on the economy as a whole as well as for their companies, in this paper we will try to analyze its advantages and usefulness, fears and uncertainties brought along with it , as well as the place of Croatia in such a process

Effect of alirocumab on lipids and lipoproteins in individuals with metabolic syndrome without diabetes: Pooled data from 10 phase 3 trials.

AimsThis analysis assessed the efficacy and safety of alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, in patients with or without metabolic syndrome (MetS) using pooled data from 10 phase 3 ODYSSEY trials.Materials and methodsData from 4983 randomized patients (1940 with MetS; 1642 with diabetes excluded) were assessed in subgroups by MetS status. Efficacy data were analysed in 4 pools per study design: 2 placebo-controlled pools (1 using alirocumab 150 mg every 2 weeks [Q2W], 1 using 75/150 mg Q2W) with background statin, and 2 ezetimibe-controlled pools (both alirocumab 75/150 mg Q2W), 1 with and 1 without background statin. Alirocumab 75/150 mg indicates possible dose increase from 75 to 150 mg at Week 12 based on Week 8 LDL-C.ResultsLDL-C percentage reduction from baseline at Week 24 with alirocumab was 63.9% (MetS) and 56.8% (non-MetS) in the pool of alirocumab 150 mg Q2W, and 42.2% to 52.2% (MetS) and 45.0% to 52.6% (non-MetS) in 3 pools using 75/150 mg Q2W. Levels of other lipid and lipoprotein parameters were also improved with alirocumab treatment, including apolipoprotein B, non-high-density lipoprotein cholesterol (non-HDL-C), lipoprotein(a) and HDL-C. Overall, the percentage change at Week 24 in LDL-C and other lipids and lipoproteins did not vary by MetS status. Adverse event rates were generally similar between treatment groups, regardless of MetS status; injection-site reactions occurred more frequently in alirocumab vs control groups.ConclusionsAcross study pools, alirocumab-associated reductions in LDL-C, apolipoprotein B, and non-HDL-C were significant vs control, and did not vary by MetS status

Testing the performance of a bilingual dictionary on topical current texts

Testing the performance of a bilingual dictionary on topical current text

A progress report of American Studies at Zagreb University

The progress report of American Studies at Zagreb University consists of: A) History B)Currently 1) Undergraduate Teaching 2) Academic Managment of Dubrovnik Seminar in American Studies 3) Introducing an M.A. Program in American Studies (Interdisciplinary) 4) Ph. D. Managment 5)Research Projects C) In the future 1) Extending the current program 2) Examining possibilities within the program 3) Trying for a new quality in our cooperation + update of repor

Two requiems by Johann Baptist Schiedermayr (1779-1840) and their reception in 19th-century Polish churches

Celem niniejszego artykułu jest dokonanie studium przypadku dwóch mszy żałobnych Johanna Baptista Schiedermayra, analiza muzyczna dzieł oraz źródłoznawcza kopii tych utworów wykorzystywanych przez kapele kościelne na ziemiach polskich w XIX wieku. Podjęte działania pozwalają na ukazanie korelacji pomiędzy artystą, jego dziełami i ich recepcją. Na wstępie przedstawiono pokrótce sylwetkę linzkiego kompozytora i multiinstrumentalisty oraz opisano jego dorobek kompozytorski. Następnie zanalizowano i porównano "Requiem Es-dur" i "Requiem c-moll", biorąc pod uwagę budowę formalną, sposób opracowywania tekstu słownego, instrumentację i elementy dzieła muzycznego na tle dorobku kompozytora. Dalej przedstawiono recepcję obu mszy żałobnych na ziemiach polskich na tle ogólnego obrazu recepcji muzyki Schiedermayra na terenach polskich, prezentując sześć zachowanych rękopisów, dokomponowane partie instrumentalne i części mszalne, a także wysnuwając wnioski dotyczące wykonawstwa i odbioru tych dzieł przez dziewiętnastowieczne kapele kościelne

lzdržljivost i oporavljanje u toku sukcesivnih statičnih napora

Investigations of repeated static work have shown that the average »output« increases with decreased load and shortened rest pause between successive efforts.Ispitivanje promjena, koje nastaju u statičnoj izdržljivosti kad se statični napor ponavlja više puta određenim tempom, dalo je ove rezultate: 1. U toku sukcesivnih napora, od kojih se svaki vrši do granice izdržljivosti, izdržljivost se smanjuje, i to tim naglije, što je odmor medu sukcesivnim naporima kraći. Pad izdržljivosti nije kontinuiran, nego se trajanje napora povremeno ustaIjuje na različitim razinama, koje su medu sobom odijeljene relativno kratkim i naglim prelazima. Nakon većeg ili manjeg broja napora izdržljivost se konačno ustaljuje na nekoj određenoj vrijednosti, koja se više ne mijenja, iako se raci nastavlja. Ta konstantna razina (definitivni plato) dostiže se to brže, što je odmor među sukcesivnim naporima duži. 2. Razina, na kojoj se izdržljivost definitivno ustaljuje. raste s dužinom odmora, ali sporije od njega. Zbog toga je prosječni radni učinak (umnožak opterećenja i izdržljivosti na platou, podijeljen s vremenom izdržljivosti i trajanjem odmora) manji uz duže odmore, nego uz kraće. 3. Prosječni radni učinak, postignut pri radu uz nisko opterećenje, veći je i na definitivnom platou od onog, koji se postiže uz visoko opterećenje. Ta razlika među radnim učincima uz različito opterećenje, manja je nego kod jednokratnih statičnih napora, ali je ipak značajna, što ukazuje, da prividno brže oporavljanje nakon jednokratnog statičnog napora izvršenog uz visoko opterećenje ne može potpuno kompenzirati faktore, koji uvjetuju, da radni učinak opada s opterećenjem. 4. Odnos između početne izdržljivosti (trajanje prvog napora) i izdržljivosti na definitivnom platou ukazuje, koliko je radne sposobnosti sačuvano u toku rada uz određene odmore. S porastom odmora medu sukcesivnim naporima raste i količina sačuvanih radnih sposobnosti. Taj porast slijedi krivulju negativne akceleracije. a jednak je i po količini i po brzini pri radu uz visoko i pri radu uz nisko opterećenje. Prema mišljenju autora, dobiveni rezultati potvrđuju njihovu raniju zamisao, po kojoj bi umor, koji se naglo razvija pri radu uz visoko opterećenje bio u prvom redu uvjetovan promjenama u živčanom sustavu, dok bi umor pri radu uz nisko opterećenje bio pretežno izazvan lokalne-kemijskim promjenama u mišićima. Kad se statični napor ponavlja. prilike su utoliko drukčije. što i pri radu uz visoko opterećenje dolazi do postepenog gomilanja metabolita u mišićima. tako da periferna komponenta umora postaje i pri radu te vrste dominantna. Zbog takvog izjednačenja u osnovnom mehanizmu, nema više razlike u djelovanju odmora na količinu sačuvanih radnih sposobnosti pri radu uz visoko i pri radu uz nisko opterećenje

Effect of Pulsed or Continuous Delivery of Salt on Sensory Perception Over Short Time Intervals

Salt in the human diet is a major risk factor for hypertension and many countries have set targets to reduce salt consumption. Technological solutions are being sought to lower the salt content of processed foods without altering their taste. In this study, the approach was to deliver salt solutions in pulses of different concentrations to determine whether a pulsed delivery profile affected sensory perception of salt. Nine different salt profiles were delivered by a Dynataste device and a trained panel assessed their saltiness using time–intensity and single-score sensory techniques. The profile duration (15 s) was designed to match eating conditions and the effects of intensity and duration of the pulses on sensory perception were investigated. Sensory results from the profiles delivered in either water or in a bouillon base were not statistically different. Maximum perceived salt intensities and the area under the time– intensity curves correlated well with the overall perceived saltiness intensity despite the stimulus being delivered as several pulses. The overall saltiness scores for profiles delivering the same overall amount of sodium were statistically not different from one another suggesting that, in this system, pulsed delivery did not enhance salt perception but the overall amount of salt delivered in each profile did affect sensory perception