Study of Bc+B_c^+ decays to the K+K−π+K^+K^-\pi^+ final state and evidence for the decay Bc+→χc0π+B_c^+\to\chi_{c0}\pi^+

A study of $B_c^+\to K^+K^-\pi^+$ decays is performed for the first time using data corresponding to an integrated luminosity of 3.0 $\mathrm{fb}^{-1}$ collected by the LHCb experiment in $pp$ collisions at centre-of-mass energies of $7$ and $8$ TeV. Evidence for the decay $B_c^+\to\chi_{c0}(\to K^+K^-)\pi^+$ is reported with a significance of 4.0 standard deviations, resulting in the measurement of $\frac{\sigma(B_c^+)}{\sigma(B^+)}\times\mathcal{B}(B_c^+\to\chi_{c0}\pi^+)$ to be $(9.8^{+3.4}_{-3.0}(\mathrm{stat})\pm 0.8(\mathrm{syst}))\times 10^{-6}$. Here $\mathcal{B}$ denotes a branching fraction while $\sigma(B_c^+)$ and $\sigma(B^+)$ are the production cross-sections for $B_c^+$ and $B^+$ mesons. An indication of $\bar b c$ weak annihilation is found for the region $m(K^-\pi^+)<1.834\mathrm{\,Ge\kern -0.1em V\!/}c^2$, with a significance of 2.4 standard deviations.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-022.html, link to supplemental material inserted in the reference

Translating the Dutch walking stairs, walking ability and rising and sitting questionnaires into German and assessing their concurrent validity with VAS measures of pain and activities in daily living

<p>Abstract</p> <p>Background</p> <p>The Dutch Walking Stairs, Walking Ability and Rising and Sitting Questionnaires are three validated instruments to measure physical activity and limitations in daily living in patients with lower extremity disorders living at home of which no German equivalents are available. Our scope was to translate the Walking Stairs, Walking Ability and Rising and Sitting Questionnaires into German and to verify its concurrent validity in the two domains pain and activities in daily living by comparing them with the corresponding measures on the Visual Analogue Scale.</p> <p>Methods</p> <p>We translated the Walking Stairs, Walking Ability and Rising and Sitting Questionnaires according to published guidelines. Demographic data and validity were assessed in 52 consecutive patients with Complex Regional Pain Syndrome 1 of the lower extremity. Information on age, duration of symptoms, type of Complex Regional Pain Syndrome 1 and type of initiating event were obtained. We assessed the concurrent validity in the two domains pain and activities in daily living by comparing them with the corresponding measures on the Visual Analogue Scale.</p> <p>Results</p> <p>We found that variability in the German Walking Stairs, Walking Ability and Rising and Sitting Questionnaires was largely explained by measures of pain and activities in daily living on the Visual Analogue Scale.</p> <p>Conclusion</p> <p>Our study shows that the domains pain and activities in daily living are properly represented in the German versions of the Walking Stairs, Walking Ability and Raising and Sitting Questionnaires. We would like to propagate their use in clinical practice and research alike.</p

Observation of Bc+ →j /ψD (∗)K (∗) decays

A search for the decays B+c→J/ψD(*)0K+ and B+c→J/ψD(*)+K*0 is performed with data collected at the LHCb experiment corresponding to an integrated luminosity of 3 fb−1. The decays B+c→J/ψ0K+ and B+c→J/ψD*0K+ are observed for the first time, while first evidence is reported for the B+c→JψD*+K*0 and B+c→J/ψD+K*0 decays. The branching fractions of these decays are determined relative to the B+c→J/ψπ+ decay. The B+c mass is measured, using the J/ψD0K+ final state, to be 6274.28±1.40(stat)±0.32(syst) MeV/c2. This is the most precise single measurement of the B+c mass to date

Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder

Lithium is the mainstay for the treatment of bipolar disorder (BD) and inhibits glycogen synthase kinase 3-β (GSK3-β). The less active GSK3-β promoter gene variants have been associated with less detrimental clinical features of BD. GSK3-β gene variants and lithium can influence brain gray matter structure in psychiatric conditions. Diffusion tensor imaging (DTI) measures of white matter (WM) integrity showed widespred disruption of WM structure in BD. In a sample of 70 patients affected by a major depressive episode in course of BD, we investigated the effect of ongoing long-term lithium treatment and GSK3-β promoter rs334558 polymorphism on WM microstructure, using DTI and tract-based spatial statistics with threshold-free cluster enhancement. We report that the less active GSK3-β rs334558*C gene-promoter variants, and the long-term administration of the GSK3-β inhibitor lithium, were associated with increases of DTI measures of axial diffusivity (AD) in several WM fiber tracts, including corpus callosum, forceps major, anterior and posterior cingulum bundle (bilaterally including its hippocampal part), left superior and inferior longitudinal fasciculus, left inferior fronto-occipital fasciculus, left posterior thalamic radiation, bilateral superior and posterior corona radiata, and bilateral corticospinal tract. AD reflects the integrity of axons and myelin sheaths. We suggest that GSK3-β inhibition and lithium could counteract the detrimental influences of BD on WM structure, with specific benefits resulting from effects on specific WM tracts contributing to the functional integrity of the brain and involving interhemispheric, limbic, and large frontal, parietal, and fronto-occipital connections

Trichomonas vaginalis: Clinical relevance, pathogenicity and diagnosis

Trichomonas vaginalis is the etiological agent of trichomoniasis, the most prevalent non-viral sexually transmitted disease worldwide. Trichomoniasis is a widespread, global health concern and occurring at an increasing rate. Infections of the female genital tract can cause a range of symptoms, including vaginitis and cervicitis, while infections in males are generally asymptomatic. The relatively mild symptoms, and lack of evidence for any serious sequelae, have historically led to this disease being under diagnosed, and under researched. However, growing evidence that T. vaginalis infection is associated with other disease states with high morbidity in both men and women has increased the efforts to diagnose and treat patients harboring this parasite. The pathology of trichomoniasis results from damage to the host epithelia, caused by a variety of processes during infection and recent work has highlighted the complex interactions between the parasite and host, commensal microbiome and accompanying symbionts. The commercial release of a number of nucleic acid amplification tests (NAATs) has added to the available diagnostic options. Immunoassay based Point of Care testing is currently available, and a recent initial evaluation of a NAAT Point of Care system has given promising results, which would enable testing and treatment in a single visit

Measurement of CP violation parameters in B-0 -> DK*(0) decays

An analysis of B-0 --> DK*(0) decays is presented, where D represents an admixture of D-0 and (D) over bar (0) mesons reconstructed in four separate final states: K-pi(+), pi K--(+), K+K- and pi(+)pi(-). The data sample corresponds to 3.0 fb(-1) of proton-proton collision, collected by the LHCb experiment. Measurements of several observables are performed, including CP asymmetries. The most precise determination is presented of r(B)(DK*(0)), the magnitude of the ratio of the amplitudes of the decay B-0 --> DK+pi(-) with a b --> u or a b --> c transition, in a K pi mass region of +/- 50 MeV/c(2) around the K*(892) mass and for an absolute value of the cosine of the K*(0) helicity angle larger than 0.4

First Observation of a Baryonic B-c(+) Decay

A baryonic decay of the B-c(+) meson, B-c(+) -> J/psi p (p) over bar pi(+) is observed for the first time, with a significance of 7.3 standard deviations, in pp collision data collected with the LHCb detector and corresponding to an integrated luminosity of 3.0 fb(-1) taken at center-of-mass energies of 7 and 8 TeV. With the B-c(+) -> J/psi pi(+) decay as the normalization channel, the ratio of branching fractions is measured to be B(B-c(+) -> J/psi p (p) over bar pi(+)) /B(B-c(+) -> J/psi pi(+)) = 0.143(-0.034)(+0.039) (stat) +/- 0.013 (syst). The mass of the B-c(+) messon is determined as M(B-c(+)) = 6274.0 +/- 0.4 (sysst) MeV/c(2), using the B-c(+) -> J/psi p (p) over bar pi(+) channel

Precision Measurement of the Mass and Lifetime of the Xi(-)(b) Baryon

We report on measurements of the mass and lifetime of the Xi(-)(b) baryon using about 1800 Xi(-)(b) decays reconstructed in a proton-proton collision data set corresponding to an integrated luminosity of 3.0 fb(-1) collected by the LHCb experiment. The decays are reconstructed in the Xi(-)(b) -> Xi(0)(c)pi(-), Xi(0)(c) -> pK(-)K(-)pi(+) channel and the mass and lifetime are measured using the Lambda(0)(b) -> Lambda(+)(c)pi(-) mode as a reference. We measure M(Xi(-)(b)) ¿ M(Lambda(0)(b)) = 178.36 +/- 0.46 +/- 0.16 MeV/c(2), (tau Xi(-)(b)/tau Lambda(0)(b)) = 1.089 +/- 0.026 +/- 0.011, where the uncertainties are statistical and systematic, respectively. These results lead to a factor of 2 better precision on the Xi(-)(b) mass and lifetime compared to previous best measurements, and are consistent with theoretical expectations

A study of the Z production cross-section in pp collisions at √s = 7 using tau final states

A measurement of the inclusive Z → ττ cross-section in pp collisions at √s =7 is presented based on a dataset of 1.0 fb[superscript −1] collected by the LHCb detector. Candidates for Z → τ τ decays are identified through reconstructed final states with two muons, a muon and an electron, a muon and a hadron, or an electron and a hadron. The production cross-section for Z bosons, with invariant mass between 60 and 120 GeV/c[superscript 2], which decay to τ leptons with transverse momenta greater than 20 GeV/c and pseudorapidities between 2.0 and 4.5, is measured to be σ[subscript pp]→Z→ττ = 71.4 ± 3.5 ± 2.8 ± 2.5 pb; the first uncertainty is statistical, the second is systematic, and the third is due to the uncertainty on the integrated luminosity. The ratio of the cross-sections for Z → τ τ to Z → μμ is determined to be 0.93 ± 0.09, where the uncertainty is the combination of statistical, systematic, and luminosity uncertainties of the two measurements.National Science Foundation (U.S.

Measurement of CP asymmetry in B-s(0) -> D-s(-/+) K-/+ decays

We report on measurements of the time-dependent CP violating observables in B-s(0) -> D-s(-/+) K--/+ decays using a dataset corresponding to 1.0 fb(-1) of pp collisions recorded with the LHCb detector. We find the CP violating observables C-f = 0.53 +/- 0.25 +/- 0.04, A(f)(Delta Gamma) = 0.37 +/- 0.42 +/- 0.20, A((f) over bar)(Delta Gamma) = 0.20 +/- 0.41 +/- 0.20, S-f = -1.09 +/- 0.33 +/- 0.08, S-(f) over bar = -0.36 +/- 0.34 +/- 0.08, where the uncertainties are statistical and systematic, respectively. Using these observables together with a recent measurement of the B-s(0) mixing phase -2 beta(s) leads to the first extraction of the CKM angle gamma from B-s(0) -> D-s(-/+) K--/+ decays, finding gamma = (115(-43)(+28))degrees modulo 180 degrees at 68% CL, where the error contains both statistical and systematic uncertainties