Inpainting the Gaps: A Novel Framework for Evaluating Explanation Methods in Vision Transformers

The perturbation test remains the go-to evaluation approach for explanation methods in computer vision. This evaluation method has a major drawback of test-time distribution shift due to pixel-masking that is not present in the training set. To overcome this drawback, we propose a novel evaluation framework called \textbf{Inpainting the Gaps (InG)}. Specifically, we propose inpainting parts that constitute partial or complete objects in an image. In this way, one can perform meaningful image perturbations with lower test-time distribution shifts, thereby improving the efficacy of the perturbation test. InG is applied to the PartImageNet dataset to evaluate the performance of popular explanation methods for three training strategies of the Vision Transformer (ViT). Based on this evaluation, we found Beyond Intuition and Generic Attribution to be the two most consistent explanation models. Further, and interestingly, the proposed framework results in higher and more consistent evaluation scores across all the ViT models considered in this work. To the best of our knowledge, InG is the first semi-synthetic framework for the evaluation of ViT explanation methods

Socio-economic factors determining in-field rainwater harvesting technology adoption for cropland productivity in Lambani Village : a case study of Thulamela Local Municipality of the Vhembe District in Limpopo Province

Thesis (MSc. (Agricultural Economics)) -- University of Limpopo, 2011In-field rainwater harvesting technology is the technique that combines the advantages of water harvesting, no till, basin tillage and mulching on high drought risk clay soils. It reduces total runoff to zero, and also considerably reduce surface evaporation. The scarcity of agricultural water is increasing at a faster rate than for other sectors in Limpopo Province. Sufficient, clean drinking water is essential to life, but millions of people throughout the world including South Africa continue to have no access to this basic necessity. This study aimed at investigating the extent and nature of adoption of in-field rainwater harvesting technology by households in Lambani village of Limpopo Province. The main objectives of this study were to identify factors determining the in-field rainwater adoption technology for cropland productivity in Lambani village and to determine the extent to which in-field rainwater harvesting adoption influences cropland productivity in Lambani village. Simple random sampling technique was used to select 70 farmers in Lambani village of Limpopo Province. Data was collected using a structured questionnaire. Descriptive statistics, logistic regression model and linear regression model were used to analyse the data. Descriptive statistics was used to describe the characteristics of households and the nature of Lambani village, and logistic regression model was used to investigate factors that determine the adoption of infield rainwater harvesting technology, while linear regression model was used to determine the extent to which in-field rainwater harvesting influence the cropland productivity in Lambani village. The results from the logistic regression model indicate that 5 variables out of 10 variables are significant in explaining farmers’ adoption decision. Land size, access to financial service, access to information and contact with extension officer are some of the variables that have significantly positive effects on the adoption of infield rainwater harvesting technology, while hired labour has significantly negative correlation with adoption. Variables such as household size, level of education, age of the household, level of income and the main water source do not significantly influence adoption of in-field rainwater harvesting. This information will help prioritiz

HIGH THROUGHPUT IMPLEMENTATION OF 64 BIT MODIFIED WALLANCE MAC USING MULTIOPERAND ADDERS

Although redundant addition is widely used to design parallel multioperand adders for ASIC implementations, the use of redundant adders on Field Programmable Gate Arrays (FPGAs) has generally been avoided. The main reasons are the efficient implementation of carry propagate adders (CPAs) on these devices (due to their specialized carry-chain resources) as well as the area overhead of the redundant adders when they are implemented on FPGAs. This project presents different approaches to the efficient implementation of generic carry-save compressor trees. In computing, especially digital signal processing, the multiply–accumulate operation is a common step that computes the product of two numbers and adds that product to an accumulator. The hardware unit that performs the operation is known as a multiplier–accumulator (MAC, or MAC unit); the operation itself is also often called a MAC or a MAC operation. Power dissipation is one of the most important design objectives in integrated circuit, after speed. Digital signal processing (DSP) circuits whose main building block is a Multiplier-Accumulator (MAC) unit. High speed and low power MAC unit is desirable for any DSP processor. This is because speed and throughput rate are always the concerns of DSP system. MAC unit consists of adder, multiplier, and an accumulator it preserves a unique mapping between input and output vector of the particular circuit. In this MAC operation is performed in two parts Partial Product Generation (PPG) circuit and Multi-Operand Addition (MOA) circui

Plants against cancer: the immune-boosting herbal microbiome: not of the plant, but in the plant. Basic concepts, introduction, and future resource for vaccine adjuvant discovery

The presence of microorganism communities (MOCs) comprised of bacteria, fungi, archaea, algae, protozoa, viruses, and the like, are ubiquitous in all living tissue, including plant and animal. MOCs play a significant role in establishing innate and acquired immunity, thereby influencing susceptibility and resistance to disease. This understanding has fostered substantial advancements in several fields such as agriculture, food science/safety, and the development of vaccines/adjuvants, which rely on administering inactivated-attenuated MOC pathogens. Historical evidence dating back to the 1800s, including reports by Drs Busch, Coley, and Fehleisen, suggested that acute febrile infection in response to “specific microbes” could trigger spontaneous tumor remission in humans. This discovery led to the purposeful administration of the same attenuated strains, known as “Coley’s toxin,” marking the onset of the first microbial (pathogen) associated molecular pattern (MAMPs or PAMPs)-based tumor immunotherapy, used clinically for over four decades. Today, these same MAMPS are consumed orally by billions of consumers around the globe, through “specific” mediums (immune boosting “herbal supplements”) as carriers of highly concentrated MOCs accrued in roots, barks, hulls, sea algae, and seeds. The American Herbal Products Association (AHPA) mandates microbial reduction in botanical product processing but does not necessitate the removal of dead MAMP laden microbial debris, which we ingest. Moreover, while existing research has focused on the immune-modulating role of plant phytochemicals, the actual immune-boosting properties might instead reside solely in the plant’s MOC MAMP laden biomass. This assertion is logical, considering that antigenic immune-provoking epitopes, not phytochemicals, are known to stimulate immune response. This review explores a neglected area of research regarding the immune-boosting effects of the herbal microbiome – a presence which is indirectly corroborated by various peripheral fields of study and poses a fundamental question: Given that food safety focuses on the elimination of harmful pathogens and crop science acknowledges the existence of plant microbiomes, what precisely are the immune effects of ingesting MAMPs of diverse structural composition and concentration, and where are these distributed in our botanicals? We will discuss the topic of concentrated edible MAMPs as acid and thermally stable motifs found in specific herbs and how these would activate cognate pattern recognition receptors (PPRs) in the upper gut-associated lymphoid tissue (GALT), including Peyer’s patches and the lamina propria, to boost antibody titers, CD8+ and CD4+ T cells, NK activity, hematopoiesis, and facilitating M2 to M1 macrophage phenotype transition in a similar manner as vaccines. This new knowledge could pave the way for developing bioreactor-grown/heat-inactivated MOC therapies to boost human immunity against infections and improve tumor surveillance

Antibacterial and cytotoxic activities of new sphingolipids and other constituents isolated from Cissus incisa leaves

Cissus incisa is used in traditional Mexican medicine to treat certain ailments, infectious or cancerous diseases. Excepting for our previous research, this species had no scientific reports validating its traditional use. In this study, we evaluated the antibacterial and cytotoxic properties of the sphingolipids and others phytocompounds isolated from C. incisa leaves to increase the scientific knowledge of the Mexican flora. The antibacterial activity was evaluated against Gram-positive and Gram-negative bacteria by the Microdilution method. Meanwhile, the cytotoxic potential was determined on six human cancer cells: PC3, Hep3B, HepG2, MCF7, A549, and HeLa; using an aqueous solution cell proliferation assay kit. A cell line of immortalized human hepatocytes (IHH) was included as a control of non-cancerous cells. Selectivity index (SI) was determined only against the hepatocellular carcinoma cell lines. The phytochemical investigation of C. incisa leaves resulted in the isolation and characterization of five compounds: 2-(20-hydroxydecanoyl amino)-1,3,4-hexadecanotriol-8-ene (1), 2,3-dihydroxypropyl tetracosanoate (2), β-sitosterol-D-glucopyranoside (3), α-amyrin-3-O-β-D-glucopyranoside (4), and a mixture of cerebrosides (5). Until now, this is the first report of the sphingolipids (1), (5-IV) and (5-V). Only the compound (4) and cerebrosides (5) exhibited antibacterial activity reaching a MIC value of 100 μg/mL against Pseudomonas aeruginosa resistant to carbapenems. While, the acetylated derivate of (3), compound (3Ac) showed the best cytotoxic result against PC3 (IC50 ¼ 43 � 4 μg/mL) and Hep3B (IC50 ¼ 49.0 � 4 μg/mL) cancer cell lines. Likewise, (3Ac) achieved better SI values on HepG2 and Hep3B cell lines. This research reveals the importance of study medicinal plants, to identify bioactive molecules as sources of potential drugs. The presence of these compounds allows us to justify the use of this plant in traditional Mexican medicine

In vitro leishmanicidal, antibacterial and antitumour potential of anhydrocochlioquinone A obtained from the fungus Cochliobolus sp

The bioassay-guided fractionation of the ethyl acetate extract of the fungus Cochliobolus sp. highlighted leishmanicidal activity and allowed for anhydrocochlioquinone A (ANDC-A) isolation. MS, 1D and 2D NMR spectra of this compound were in agreement with those published in the literature. ANDC-A exhibited leishmanicidal activity with EC50value of 22.4 \uc2\ub5g/mL (44 \uce\ubcM) and, when submitted to the microdilution assay against Gram-positive and Gram-negative bacteria, showed a minimal inhibitory concentration against Staphylococcus aureus ATCC 25295 of 128 \uce\ubcg/mL (248.7 \uce\ubcM). It was also active against five human cancer cell lines, showing IC50values from 5.4 to 20.3 \uce\ubcM. ANDC-A demonstrated a differential selectivity for HL-60 (SI 5.5) and THP-1 (SI 4.3) cell lines in comparison with Vero cells and was more selective than cisplatin and doxorubicin against MCF-7 cell line in comparison with human peripheral blood mononuclear cells. ANDC-A was able to eradicate clonogenic tumour cells at concentrations of 20 and 50 \uce\ubcM and induced apoptosis in all tumour cell lines at 20 \uce\ubcM. These results suggest that ANDC-A might be used as a biochemical tool in the study of tumour cells biochemistry as well as an anticancer agent with durable effects on tumours

Rapid dynamic changes of FL.2 variant : a case report of COVID-19 breakthrough infection

AVAILABILITY OF DATA AND MATERIALS : The figures and tables of the study are included in the manuscript. The FASTA files are deposited in the Global Initiative on Sharing All Influenza Data (GISAID) database https://doi.org/10.55876/gis8.230821xh : Day-08 is EPI_ISL_17601323[hCoV-19/Botswana/BHP_0123017470/2023], and Day-21 is EPI_ISL_17601322[hCoV-19/Botswana/BHP_1100219671/2023].We investigated intra-host genetic evolution using two SARS-CoV-2 isolates from a fully vaccinated (primary schedule x2 doses of AstraZeneca plus a booster of Pfizer), >70-year-old woman with a history of lymphoma and hypertension who presented a SARS-CoV-2 infection for 3 weeks prior to death due to COVID-19. Two full genome sequences were determined from samples taken 13 days apart with both belonging to Pango lineage FL.2: the first detection of this Omicron sub-variant in Botswana. FL.2 is a sub-lineage of XBB.1.9.1. The repertoire of mutations and minority variants in the Spike protein differed between the two time points. Notably, we also observed deletions within the ORF1a and Membrane proteins; both regions are associated with high T-cell epitope density. The internal milieu of immune-suppressed individuals may accelerate SARS-CoV-2 evolution; hence, close monitoring is warranted.Supported by the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE) which is funded by the Science for Africa Foundation to the Developing Excellence in Leadership, Training and Science in Africa (DELTAS Africa) programme [Del-22-007] with support from Wellcome Trust and the UK Foreign, Commonwealth & Development Office and is part of the EDCPT2 programme supported by the European Union; the Bill & Melinda Gates Foundation [INV-033558]; and Gilead Sciences Inc., [19275]. This work was also supported by the National Institutes of Health NIH Fogarty International Center K43 TW012350. Sequencing was supported by funding from the Foundation for Innovation in Diagnostics, the Bill and Melinda Gates Foundation, the National Institutes of Health Fogarty International Centre, the HHS/NIH/National Institute of Allergy and Infectious Diseases (NIAID) and the Africa Centers of Disease Control through the Pathogen Genomics Initiative.http://www.elsevier.com/locate/ijidhj2024School of Health Systems and Public Health (SHSPH)SDG-03:Good heatlh and well-bein

A WEB-BASED SOLUTION TO VISUALIZE OPERATIONAL MONITORING LINUX CLUSTER FOR THE PROTODUNE DATA QUALITY MONITORING CLUSTER

The Neutrino computing cluster made of 300 Dell PowerEdge 1950 U1 nodes serves an integral role to the CERN Neutrino Platform (CENF). It represents an effort to foster fundamental research in the field of Neutrino physics as it provides data processing facility. We cannot begin to over emphasize the need for data quality monitoring coupled with automating system configurations and remote monitoring of the cluster. To achieve these, a software stack has been chosen to implement automatic propagation of configurations across all the nodes in the cluster. The bulk of these discusses and delves more into the automated configuration management system on this cluster to enable the fast online data processing and Data Quality (DQM) process for the Neutrino Platform cluster (npcmp.cern.ch)