Influence the octenidine dihydrochloride on the tissues of knee joints of immature laboratory rats

An effect of antiseptics on the joints tissue growing organism requires further study, which is primarily due to the need of foresight and reducing the consequences of carried diseases. The aim. of the reserch is to determine the concentration of the octenidine dihydrochloride ("Octenisept"), antiseptics, whose effectiveness is proved concerning to a wide range of microorganisms, in which it can be used in septic diseases of the musculoskeletal system of the growing organism. The research of influence on the joints tissue the octenidine dihydrochloride in different partings studied in experiments on 40 immature 2-month-old white laboratory rats. Reactive and inflammatory changes, which expressed in different degrees, noted in the synovial layer of the animals‘ joint capsule, virtually in all animals in an experimental and control group. Significant differences observed in animals of the first control group (6 hours after washing the joint) where the thickness index of synovial layer, concerning the intact animals were by 16, 8 % higher. The thickness of the capsule was significantly higher than in the capsule of the intact animals and animals in the knee joint study group. Thus, in the group of animals where the joint was washed on octenidine dihydrochloride at 1:4 dilution, the thickness of the capsule was by 33.6 % more, in the group of animals with joint lavage octenidine dihydrochloride at a dilution of 1:3 through 6:00 capsule thickness values were (about intact animals) by 38.8 % higher, and after 12 hours - by 22.5 %. Based on the results obtained on the effect of octenidine dihydrochloride (taken at different dilutions) in the tissue of the knee joint, revealed that it has no toxic effect on articular cartilage and synovial membrane and other components of the joint. Using of the preparation at the 1:4 dilution does not cause inflammatory changes in the tissues of the joints, laboratory animals, allowing its using in this concentration in the treatment of inflammatory diseases of the musculoskeletal system in the growing organism

Analysis influence of an experimental hemodynamic overload on the secretory components state of a heart

In this research were described mast cells and secretory myocardiocytus of a heart at the people with different age groups – youth, mature, elderly and senile, in a norm, and numerous changes of the heat parts in the conditions of experimental aortic narrowing and at the action of epinephrin and deхamethazon. It was found out the distinctions in morphology of secretory components in the different departments of heart. With age there is multiplying the amount of connecting tissue and amount of secretory myocardiocytus, which was also correlated with different types of mast cells changes. Hemodynamic overload and adrenalin activates the secretory components of heart, and deхamethazon activates the secretory myocardiocytus, but reduces activity of mast cells

Optical characterization of Polar winter aerosols and clouds

The Arctic region is particularly sensitive to climate change and has recently undergone major alterations including a dramatic decrease of sea-ice extent. Our ability to model and potentially mitigate climate change is limited, in part, by the uncertainties associated with radiative forcing due to direct and indirect aerosol effects which in turn are dependent on our understanding of aerosol and cloud processes. Aerosol loading can be characterized by aerosol optical depth (AOD) which is the most important (extensive or bulk) aerosol radiative parameter and arguably the most important regional indicator of aerosol behavior. One of the most important shortcomings in our understanding of Arctic aerosols is their behavior during the Polar winter. A major reason for this is the lack of night-time AOD measurements. In this work we use lidar and starphotometry instruments in the Arctic to obtain vertically resolved aerosol profiles and column in- tegrated representations of those profiles (AODs) respectively. In addition, data from a space-borne lidar (CALIOP) is used to provide a pan-Arctic context and seasonal statistics in support of ground based measurements

Applications of magnetostrictive and magnetorheological materials in modern car industry and future trends

Magnetostrictive and magnetorheological materials are becoming more widespread due to their unique properties, especially within the automotive industry. This research investigates the applications of MS and MR materials in the car industry, their limitations, and possible future trends. Literature review, expert interviews, and industry reports have been used to acquire data, while the validity of the results was ensured using triangulation. Results indicate that there are many applications of magnetostrictive and magnetorheological materials, already implemented or just being researched at the moment, from actuators and sensors to injectors and bumpers, controlled with the magnetic field. Even considering several limitations such as high price point or a need for special techniques, for example, to prevent the in-use-thickening of MR fluids, identified trends are positive, especially in terms of the development of new materials and integration of those into vehicle components

Consideration Of A Religious Factor When Determining The Tourist Motivation

This article analyzes religious objects, religious organizations, and objects of pilgrim tourism of the Republic of Tatarstan and the city of Kazan. The article shows the necessary activities for the development of religious tourism in Tatarstan and the city of Kazan. One of the main tasks of the work is to perform both qualitative and quantitative analysis of religious tourism objects and make an attempt as a whole to determine the potential for the development of religious tourism, to look for opportunities for the development of this type of tourism in the study area. The article also discusses the development of religious tourism in the region in terms of interethnic and interfaith interaction. In addition to Islam and Christianity, there are many different religions in the republic, which makes it very attractive for representatives of other religions and for travelers who treat objects of religion as a cultural heritage. An attempt is made to take into account the religious factor in segmenting the tourist market of Kazan. Accordingly, the article considers the features of the application of psychographic classifications in relation to the tourism industry. An attempt was made to use the methodological apparatus in the study of the regional tourism sector in the formation of the "portrait" of a modern tourist, considering religious tourists. The individual routes for religious tourisешс sites offered by tour operators of Tatarstan are analyzed.Certain attention is paid to the current state of halal tourism in Tatarstan to create a new tourist route. A tour was developed, a technological map of the route was created, and costing of the new Islamic World route was made

Analysis of indicators of public health in the Kamensko-Dneprovskyi rural region.

Purpose of the research performed by the cohort method is to study the levels of public health among children and adults living in the rural industrial area of the Zaporizhzhia region. In order to estimate primary and overall disease incidence by the separate nosological forms in children and adult population: (C00-C97), (E10-E14), (I10-I15), (I20-I25), (J95- J99), (K20-K31) retrospective research was carried out according to the ICD-10. Scientific substantiation of the research in the rural district was based on the following categories: choosing category of the adult population and children aged 0-14 years to 15-17 years, social-hygienic parameters, types of water supply systems. Investigation of the incidence was carried out according to the report of Information Health Department Centre for the period of 2008-2016 years. The main factors which influence the formation of public health are demographic indicators of different age groups, as well as indicators of dispensary supervision (the composition of health groups, the proportion of frequently ill children) on the territory of  experimental observation area.  In our research we tried to study these two groups of medical and social factors to understand the conditions under which  health of the rural population in this industrially developed region of Ukraine is being formed. The percent of  organized groups of frequently ill childrenl in the Kamensko-Dniprovskyi rural district during 2008-2016 observation period increased from 53.3% in 2008 to 68.2% in  2016, which also testifies to a negative tendency to increase in the rate of children falling  ill more than 4 times during 1 year, and the low resistance of the body to acute viral infections

Morphological features of drainage systems of the testicle

Objective. To determine the peculiarities of organization of morphological structures of the drainage systems of a testicle and their role in pathogenesis of infertility in the men. Маterials and methods. The structure and interrelationship of morphological parameters of the drainage systems of a testicle were investigated in 71 biopsies of a testicle, excised during necropexy in men of the adult age (22 - 35 yrs old). On histological preparations of testicles, using morphometric rule АМ-9-4 and the Stefanov’s net on 25 points, there were measured the external diameters of the arteriolas, capillaries, venulas and the nerves. Results. During tоtal investigation of histological sections of the ductus deferens preparations in part of a deep ring of inguinal channel there were obtained following morphological data: the Abstract quantity of big vessels in all the sections of preparations consisted of 16 аrteries with a general square 51.3805 × 10-3 mm2; 28 veins with general square 38.2511 × 10-3 mm²; 18 аrteiols with general square 2.8136 × 10-3 mm²; 30 venulas with general square 2.2681 × 10-3 mm²; there were revealed as well 4 nerves of general square 0.3686 × 10-3 mm² and 4 neural trunks of general square 3.5801 × 10-3mm². Conclusion. The data obtained, concerning histological and morphological investigation of samples of ductus deferens confirms probability, that in its proximal part the blood-bearing vessels are present, which are bigger but lesser in number, while the nerves, diameter of which is objectively lesser than in the nerves trunks, are more pronounced in direction of distal part of ductus deferens

Clinical study of morphological changes in the arterial blood supply of the testicle in children

Objective. Studying of clinical and morphological changes in the arterial blood supply of testicle in its surgical diseases and improvement of the surgical treatment tactics. Materials and methods. In the morphological stage of the study, there was obtained the material from 71 preparations of testicle and epitesticle, which were taken while doing necropsy in men of a mature age (22 – 35 years old), also there were processed 38 preparations of membranes in dropsy testicle, taken in a life–time, as well as postoperative material (in non–complete obliteration of vaginal sprout of peritoneum), and 17 testicular biopsy specimens, obtained in infertile men, which were taken during surgical intervention on testis in pediatric patients. Results. Introduction of the innovative method and implementation of complex program for diagnosis and surgical treatment of the testicular diseases in children into clinical practice have permitted to improve a testicular blood supply and to reduce a risk of the ischemia occurrence. Conclusion. Clinical and morphological changes in the arterial blood supply as a part of drainage systems of the testicle in its surgical diseases are expressed in development of total vascular spasm and ischemia, which were caused by narrowing of the arteries lumen, compensatory hypertrophy of the muscle layers of arterial wall, thickening of basal membranes, leading to increase in the number of blood vessels, sclerotic changes in stroma of spermatic cord, deformation of the ductus deferens

Лапароскопічна корекція рецидивних пахвинних гриж у дітей

Repeated surgery for inguinal hernia recurrence in children performed by traditional access to the inguinal area, always has complications such as presence of rough scars and disruption to the normal anatomical relationships between organs and tissues of inguinal area. High traumatic re-intervention, also has complications such as presence of adhesions between elements of cremasteric muscle and spermatic cord in boys and significant spikes in the area round ligament of the uterus in girls, leading to a gross disorder of all levels of drainage testes in boys and development of vascularization ovarian disorders in girls. These factors encourage pediatric surgeons to find new, less traumatic and highly efficient methods of surgical treatment of recurrent inguinal hernias in children. These objectives are fully satisfied by our improved method of laparoscopic correction of recurrent inguinal hernias with conducting intraoperative ultrasound control of inguinal area in the intervention part. During the period from 2013 to 2015 in the Surgical Department of “Specialized Clinical Medical Centre of a Mother and a Child by Prof. M. Ph. Rudniev” in Dnipro, Ukraine there were performed 18 laparoscopic interventions for recurrent inguinal hernias in children whose first intervention was performed by traditional access to the inguinal area. All the children were under the age of 3 years. While analyzing the cases of relapse of inguinal hernias we found that relapses appear in young children, and more often after surgery on strangulated inguinal hernias, which are operated by traditional methods. Thus, our proposed method of laparoscopic correction of recurrent inguinal hernias allows eliminating the inguinal hernia sac without further injury of inguinal canal structures that are in a state of rumen process that came after previous surgery in the inguinal area. In addition, good cosmetic effect of repeated surgery prevents the formation of adhesions and postoperative coarse scars. In the course of our work, it is proved that among the measures aimed at the restoration of the drainage of the testes in disorder of the obliteration of the vaginal process of peritoneum in boys and to preserve the vascularization of the ovary in girls is dominated: timely re-surgical treatment of children, the use of pathogenesis reasonable way of surgical correction pathology at deep inguinal ring using modern laparoscopic technique.Повторная операция по поводу рецидива паховой грыжи у детей, которая выполняется традиционным доступом в паховой области, всегда осложняется наличием грубых рубцов и нарушением обычных анатомических отношений между органами и тканями паховой области. Высокая травматичность повторного вмешательства также осложняется наличием сращений между кремастерных мышцей и элементами семенного канатика у мальчиков и значительными спайками в области круглой связки матки у женщин, что приводит к грубому нарушению всех звеньев дренажных систем яички у мальчиков и развития нарушений васкуляризации яичника у женщин. Приведенные факторы побуждают детских хирургов к поиску новых, менее травматичных и высокоэффективных методов операционного лечения рецидивных паховых грыж у детей. Этим задачам в полной мере соответствует усовершенствованный нами способ лапароскопической коррекции рецидивной паховой грыжи с проведением интраоперационного УЗИ-контроля паховой области со стороны вмешательства. За период с 2013 до 2015 г.. В хирургическом отделении КЗ "ДСКМЦМД им. проф. М. Ф. Руднева "ДОР м. Днепр было выполнено 18 лапароскопических вмешательств при рецидивирующих паховых грыжах у детей, которым первое вмешательство выполняли традиционным доступом в паховой области. Все дети были в возрасте до 3 лет. При анализе случаев рецидива паховых грыж пришли к выводу, что рецидивы появлялись у детей раннего возраста и, чаще, после операционных вмешательств по поводу ущемленных паховых грыж, которые оперировали традиционными способами. Таким образом, предложенный нами способ лапароскопической коррекции рецидивных паховых грыж позволяет ликвидировать грыжевой мешок без дополнительного травмирования структур пахового канала, которые находятся в состоянии рубцового процесса, возникший после предыдущего хирургического вмешательства в паховой области. Кроме того, хороший косметический эффект операции препятствует формированию повторных спаек и грубых послеоперационных рубцов. В ходе проведенной нами работы доказано, что среди мер, направленных на восстановление нарушений дренажных систем яичка при нарушении облитерации влагалищного отростка брюшины у мальчиков и для сохранения васкуляризации яичника у женщин, главное место занимают: своевременное повторное хирургическое лечение детей, использование патогенетически обоснованных способов хирургической коррекции патологии на уровне глубокого пахового кольца с использованием современной лапароскопической техники.Повторна операція з приводу рецидиву пахвинної грижі у дітей, яка виконується традиційним доступом у пахвинній ділянці, завжди ускладнюється наявністю грубих рубців та порушенням звичайних анатомічних відношень між органами та тканинами пахвинної ділянки. Висока травматичність повторного втручання також ускладнюється наявністю зрощень між кремастерним м’язом та елементами сім’яного канатика у хлопчиків та значними спайками в ділянці круглої зв’язки матки у дівчат, що призводить до грубого порушення усіх ланок дренажних систем яєчка у хлопчиків та розвитку порушень васкуляризації яєчника у дівчат. Наведені чинники спонукають дитячих хірургів до пошуку нових, менш травматичних та високоефективних методів операційного лікування рецидивних пахвинних гриж у дітей. Цим завданням повною мірою відповідає вдосконалений нами спосіб лапароскопічної корекції рецидивної пахвинної грижі з проведенням інтраопераційного УЗД-контролю пахвинної ділянки з боку втручання. За період з 2013 до 2015 р. у хірургічному відділенні КЗ “ДСКМЦМД ім. проф. М. Ф. Руднєва” ДОР м. Дніпра було виконано 18 лапароскопічних втручань при рецидивних пахвинних грижах у дітей, яким перше втручання виконували традиційним доступом у пахвинній ділянці. Всі діти були у віці до 3 років. При аналізі випадків рецидиву пахвинних гриж дійшли висновку, що рецидиви з’являлися у дітей раннього віку і, частіше, після операційних втручань з приводу защемлених пахвинних гриж, які оперували традиційними способами. Таким чином, запропонований нами спосіб лапароскопічної корекції рецидивних пахвинних гриж дозволяє ліквідувати грижовий мішок без додаткового травмування структур пахвинного каналу, які перебувають у стані рубцевого процесу, що виник після попереднього хірургічного втручання в пахвинній ділянці. Крім того, гарний косметичний ефект операції перешкоджає формуванню повторних спайок та грубих післяопераційних рубців. У ході проведеної нами роботи доведено, що серед заходів, які спрямовані на відновлення порушень дренажних систем яєчка при порушенні облітерації піхвового відростка очеревини у хлопчиків та для збереження васкуляризації яєчника у дівчат, головне місце займають: своєчасне повторне хірургічне лікування дітей, використання патогенетично обґрунтованих способів хірургічної корекції патології на рівні глибокого пахвинного кільця з використанням сучасної лапароскопічної техніки.