7 research outputs found
Synthesis of process related Dapsone impurities : Selective diazotization of aromatic di-amine
No full textEfficient Synthesis of Unsymmetrical Dibenzothiophenes by Acid-Mediated Intramolecular Cyclization of Biaryl Methyl Sulfoxides
Full text linkDiscovery of inhibitors of plasminogen activator inhibitor-1: Structure–activity study of 5-nitro-2-phenoxybenzoic acid derivatives
Full text linkCommercial Manufacturing of Propofol: Simplifying the Isolation Process and Control on Related Substances
Full text linkSynthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element
Full text linkCommercial Manufacturing of Propofol: Simplifying the Isolation Process and Control on Related Substances
No full textA commercially
viable manufacturing process for propofol (<b>1</b>) is described.
The process avoids acid–base neutralization
events during isolation of intermediate, 2,6-di-isopropylbenzoic acid
(<b>3</b>) and crude propofol, and thus simplifies the synthesis
on industrial scale to a considerable extent. Syntheses of five impurities/related
substances (USP and EP) are also described
