An Ethical Analysis of Difficulties of Modern Enrollment Management and Evaluation Mechanisms

The education development is the essence of dynamic knowledge architecture. With the increases of college entrance examination candidates, institutions and running points, China’s education has been in the rapid development since the 1990s. It has been became a hot explore object of educators to put forward the higher requirements of Enrollment Management, to further improve the enrollment management process and to establish appropriate evaluation mechanisms. Thus, this paper analyzes the characteristics of the modern recruitment, puts forward the difficulties and the measures of the enrollment management process and elaborates the related guarantee methods. These principles can provide some references of modern recruitment and promote China’s education development

Research and Application of Personalized Modeling Based on Individual Interest in Mining

Weibo services, provided by the service providers, is simple and changeless. The research based on the content of microblog reflects the user’s personalized features. The method has important significance to improve user satisfaction and expand the scale of users. First, the interest classification problem called multiclass classification algorithm is proposed based on improving support vector machine of binary tree. Second, an improved model of mixed interest based on implicit feedback is proposed. This method is based on the shortcomings of the establishment of the interest model and the drift strategy in update phase among existing users. The improved model is applied to the user modeling of personalization, improving the authenticity and accuracy of the personalized modeling

The Finding and Dynamic Detection of Opinion Leaders in Social Network

It is valuable for the real world to find the opinion leaders. Because different data sources usually have different characteristics, there does not exist a standard algorithm to find and detect the opinion leaders in different data sources. Every data source has its own structural characteristics, and also has its own detection algorithm to find the opinion leaders. Experimental results show the opinion leaders and theirs characteristics can be found among the comments from the Weibo social network of China, which is like Facebook or Twitter in USA

Absolute and relative POD of LEO satellites in formation flying: Undifferenced and uncombined approach

Absolute or relative precise orbit determination (POD) is an essential prerequisite for many low earth orbit (LEO) missions. The POD of LEO satellites typically relays on processing the onboard global navigation satellite system (GNSS) measurements. The absolute POD is usually based on an ionosphere-free (IF) combination, and currently, integer ambiguity resolution (IAR) can be achieved only when external GNSS satellite phase bias (SPB) products are used. The use of these products is not flexible in multi-frequency/multi-constellation scenarios and is difficult to achieve in real-time missions. For relative POD, the double-differenced (DD) with IAR is the most general method. However, the differencing process amplifies observation noise and loses the opportunity to impose dynamic constraints on some eliminated parameters. In this contribution, based on the use of undifferenced and uncombined (UDUC) observations, a new model for both absolute and relative POD is proposed. In this model, the ambiguities of common-view satellites are constructed into DD form, thus IAR can be achieved without any external SPB products. Working with the UDUC observations, multi-frequency scenarios can be easily applied, and residuals can be separated for each frequency. In addition, with precise GNSS satellite clock/orbit products, both the absolute and relative orbits can be derived, which supports absolute and relative LEO POD. Based on onboard GPS observations of T-A and T-B satellites in formation flying, the performance of the UDUC POD model with DD ambiguity was evaluated. With the UDUC algorithm and IAR, the proposed model presented a consistency of 2.8–3.8 cm in 3D with the reference orbits, and the orbit difference was reduced by 16.3% and 10.6% for T-A and T-B compared with the IF-based POD, respectively. In addition, the relative orbit of the two satellites derived from the proposed model showed a consistency of 1.1–1.5 mm, which proved the feasibility of the UDUC POD model with DD ambiguity for formation flying missions

Enhancement of Vaccinia Virus Based Oncolysis with Histone Deacetylase Inhibitors

Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation, the goal of this study is to determine whether HDI can also enhance the potency of these poxviruses in infection-resistant cancer cell lines. Multiple HDIs were tested and Trichostatin A (TSA) was found to potently enhance the spread and replication of a tumour selective vaccinia virus in several infection-resistant cancer cell lines. TSA significantly decreased the number of lung metastases in a syngeneic B16F10LacZ lung metastasis model yet did not increase the replication of vaccinia in normal tissues. The combination of TSA and VV increased survival of mice harbouring human HCT116 colon tumour xenografts as compared to mice treated with either agent alone. We conclude that TSA can selectively and effectively enhance the replication and spread of oncolytic vaccinia virus in cancer cells