Digital architecture and difference: a theory of ethical transpositions towards nomadic embodiments in digital architecture

This thesis contributes to histories and theories of digital architecture of the past two decades, as it questions the narratives of its novelty. The main argument this thesis puts forward is that a plethora of methodologies, displacing the centrality of the architect from the architectural design process, has folded into the discipline in the process of its rewriting along digital protocols. These steer architecture onto a post-human path. However, while the redefinition of the practice unfolds, it does so epistemically only without redefining the new subject of architecture emerging from these processes, which therefore remains anchored to humanist-modern definitions. This unaccounted-for position, I argue, prevents novelty from emerging. Simultaneously, the thesis unfolds a creative approach – while drawing on nomadic, critical theory concepts, there surfaces an alternative genealogy already underpinning digital methodologies that enable a reconceptualization of novelty framed with difference to be articulated through nomadic digital embodiment. Regarding the first claim, I turn to the narratives as well as to the mechanisms of digital discourse emerging in two modes of production – mathematical and biological – in exploration of the ways perceptions of novelty are articulated: a) through close readings of its narratives as they consolidate into digital architectural theory (Carpo 2011; Lynn 2003, 2012; Terzidis 2006; Migayrou 2004, 2009); b) through an analysis of the two digital methodologies that support these narratives – parametric architecture and biodigital architecture. In parallel, this thesis draws on twentieth-century critical theory and twenty-firstcentury nomadic feminist theory to rethink two thematic topics: difference and subjectivity. Specifically, these are Gilles Deleuze’s non-essentialist, nonrepresentational philosophy of difference (1968, 1980, 1988) and Rosi Braidotti’s nomadic feminist reconceptualization of post-human, nonunitary subjectivity (2006, 2011, 2015). Nomadic feminist theory also informs my methodology. I draw on Rosi Braidotti’s cartographing and transposing (2006, 2011) because they engender a non-dualist approach to research itself that is dynamic and affirmative, insisting on grounding techniques – grounding in subject positions that are nevertheless post-human and nonunitary. This leads to a redefinition of novel digital practices with ethical ones

Harnessing Soluble NK Cell Killer Receptors for the Generation of Novel Cancer Immune Therapy

The natural cytotoxic receptors (NCRs) are a unique set of activating proteins expressed mainly on the surface of natural killer (NK) cells. The NCRs, which include three members; NKp46, NKp44 and NKp30, are critically involved in NK cytotoxicity against different targets, including a wide range of tumor cells derived from various origins. Even though the tumor ligands of the NCRs have not been identified yet, the selective manner by which these receptors target tumor cells may provide an excellent basis for the development of novel anti-tumor therapies. To test the potential use of the NCRs as anti-tumor agents, we generated soluble NCR-Ig fusion proteins in which the constant region of human IgG1 was fused to the extracellular portion of the receptor. We demonstrate, using two different human prostate cancer cell lines, that treatment with NKp30-Ig, dramatically inhibits tumor growth in vivo. Activated macrophages were shown to mediate an ADCC response against the NKp30-Ig coated prostate cell lines. Finally, the Ig fusion proteins were also demonstrated to discriminate between benign prostate hyperplasia and prostate cancer. This may provide a novel diagnostic modality in the difficult task of differentiating between these highly common pathological conditions

Dilemmatic human-animal boundaries in Britain and Romania: Post-materialist and materialist dehumanization

This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2007 The British Psychological SocietyTheories of dehumanization generally assume a single clear-cut, value-free and non-dilemmatic boundary between the categories ‘human’ and ‘animal.’ The present study highlights the relevance of dilemmas involved in drawing that boundary. In 6 focus groups carried out in Romania and Britain, 42 participants were challenged to think about dilemmas pertaining to animal and human life. Four themes were identified: rational autonomy, sentience, speciesism, and maintaining materialist and postmaterialist values. Sentience made animals resemble humans, while humans’ rational autonomy made them distinctive. Speciesism underlay the human participants’ prioritization of their own interests over those of animals, and a conservative consensus that the existing social system could not change supported this speciesism when it was challenged. Romanian participants appealed to Romania’s lack of modernity and British participants to Britain’s modernity to justify such conservatism. The findings suggest that the human-animal boundary is not essentialized; rather it seems that such boundary is constructed in a dilemmatic and post hoc way. Implications for theories of dehumanization are discussed

Exposure to Violence and Attitudes Towards Transitional Justice

Transitional justice has emerged to address victims' needs as a means of restoring relations broken by violence. Yet we know little about victims' attitudes towards different transitional justice mechanisms. Why do some victims prioritize retributive justice while others favor other forms of dealing with the violent past? What determines victims' attitudes towards transitional justice policies? To address these questions, we offer a new theoretical framework that draws upon recent insights from the field of evolutionary psychology and links both war exposure and postwar environments to transitional justice preferences. We argue that both past experiences of wartime violence and present-day social interdependence with perpetrators impact transitional justice preferences, but in divergent ways (resulting in greater support for retributive vs. restorative justice measures, respectively). To test our framework, we rely upon a 2013 representative survey of 1,007 respondents focusing on general population attitudes towards transitional justice in Bosnia two decades after the implementation of the Dayton Accords. Specifically, we examine the impact of displacement, return to prewar homes, loss of property, loss of a loved one, physical injury, imprisonment, and torture on attitudes towards transitional justice. On the whole, our findings confirm our two main hypotheses: Exposure to direct violence and losses is associated with more support for retributive justice measures, while greater present-day interdependence with perpetrators is associated with more support for restorative justice measures. While acknowledging the legacy of wartime violence, we highlight the importance of the postwar context and institutional mechanisms that support victims in reconstructing their lives

Sparse and Constrained Stochastic Predictive Control for Networked Systems

This article presents a novel class of control policies for networked control of Lyapunov-stable linear systems with bounded inputs. The control channel is assumed to have i.i.d. Bernoulli packet dropouts and the system is assumed to be affected by additive stochastic noise. Our proposed class of policies is affine in the past dropouts and saturated values of the past disturbances. We further consider a regularization term in a quadratic performance index to promote sparsity in control. We demonstrate how to augment the underlying optimization problem with a constant negative drift constraint to ensure mean-square boundedness of the closed-loop states, yielding a convex quadratic program to be solved periodically online. The states of the closed-loop plant under the receding horizon implementation of the proposed class of policies are mean square bounded for any positive bound on the control and any non-zero probability of successful transmission

An Agent-Based Model of Collective Emotions in Online Communities

We develop a agent-based framework to model the emergence of collective emotions, which is applied to online communities. Agents individual emotions are described by their valence and arousal. Using the concept of Brownian agents, these variables change according to a stochastic dynamics, which also considers the feedback from online communication. Agents generate emotional information, which is stored and distributed in a field modeling the online medium. This field affects the emotional states of agents in a non-linear manner. We derive conditions for the emergence of collective emotions, observable in a bimodal valence distribution. Dependent on a saturated or a superlinear feedback between the information field and the agent's arousal, we further identify scenarios where collective emotions only appear once or in a repeated manner. The analytical results are illustrated by agent-based computer simulations. Our framework provides testable hypotheses about the emergence of collective emotions, which can be verified by data from online communities.Comment: European Physical Journal B (in press), version 2 with extended introduction, clarification

Detecting Deepfakes Without Seeing Any

Deepfake attacks, malicious manipulation of media containing people, are a serious concern for society. Conventional deepfake detection methods train supervised classifiers to distinguish real media from previously encountered deepfakes. Such techniques can only detect deepfakes similar to those previously seen, but not zero-day (previously unseen) attack types. As current deepfake generation techniques are changing at a breathtaking pace, new attack types are proposed frequently, making this a major issue. Our main observations are that: i) in many effective deepfake attacks, the fake media must be accompanied by false facts i.e. claims about the identity, speech, motion, or appearance of the person. For instance, when impersonating Obama, the attacker explicitly or implicitly claims that the fake media show Obama; ii) current generative techniques cannot perfectly synthesize the false facts claimed by the attacker. We therefore introduce the concept of "fact checking", adapted from fake news detection, for detecting zero-day deepfake attacks. Fact checking verifies that the claimed facts (e.g. identity is Obama), agree with the observed media (e.g. is the face really Obama's?), and thus can differentiate between real and fake media. Consequently, we introduce FACTOR, a practical recipe for deepfake fact checking and demonstrate its power in critical attack settings: face swapping and audio-visual synthesis. Although it is training-free, relies exclusively on off-the-shelf features, is very easy to implement, and does not see any deepfakes, it achieves better than state-of-the-art accuracy.Comment: Our code is available at https://github.com/talreiss/FACTO

Emilie du Châtelet—On Knowledge and Matter

This paper suggests a reading of the early 18th-century philosopher Emilie du Châtelet’s position on the questions of knowledge and matter as a surprising early precursor to technoscience/ posthuman feminism’s stand on scientific methodology and embodiment. In her 1740 book Institution de Physics (Foundations of Physics), du Châtelet, in an enlightenment fashion, turns to empiricism in an attempt to explain how we acquire scientific knowledge with an aim to account for the physical world and specifically for bodily agency. It is empiricism that leads her to criticise both the Cartesians as well as the Newtonians disembodied account of force. Du Châtelet’s main quarrel with Newton’s theory of bodies arises from its insufficiency to account for matter as vital. It is here that she turns to Leibniz’s metaphysics in a move that, in effect, redefines the premise of reason. Having an insight into her intellectual world at the dawn of enlightenment highlights the tendencies of our scientific paradigm to account for bodies as nonlogical and affirms the technoscience/ posthuman feminist transformative project

Contaminations of soil and two Capsicum annuum generations irrigated by reused urban wastewater treated by different reed beds

Background: In order to save potable water, this study aims to evaluate the contamination of soil and Capsicum annuum L. (chilli) watered with urban wastewater (sewage) pre-treated by various wetland systems. Methods: The appropriateness of wetland outflow for irrigation when applying reused wastewater with high contamination of minerals and pathogens was assessed. The impact of wastewaters pre-treated by various wetlands on soil and harvest was tested in terms of mineral and biological contamination risk. Results: The wetlands met the standards for irrigation water for most water quality variables. However, the thresholds for key water quality parameters were significantly (p < 0.05) exceeded. The highest values for total coliforms, ammonium-nitrogen, phosphorus and potassium were 157,072 CFU/100 mL, 8.5 mg/L, 5.0 mg/L, and 7.0 mg/L, respectively. The harvest was moderately polluted only by zinc according to vegetable quality standards (threshold of 50 mg/kg). Zinc concentrations for Filters 2, 4, 6, 7 and 8 were 35.8, 60.6, 65.1, 65.5 and 53.2 mg/kg, respectively. No bacterial contamination was detected. Conclusions: Treatment of domestic wastewater applying constructed wetlands and subsequent recycling of the treated wastewater for irrigation of crops is a good substitute to the traditional application of drinking water for irrigation purposes

What makes you think that you are a health expert? : the effect of objective knowledge and cognitive structuring on self-epistemic authority

Self-epistemic authority (SEA) refers to the subjective judgement of the level of expertise and knowledge a person has in a given domain. While it is reasonable to assume that people's perception of SEA reflects their level of objective knowledge in the given domain, there is evidence to show that people are not optimal judges of their own knowledge. Thus, the present study examined the interaction between the participants’ trait-like characteristics of need for cognitive closure (NFC) and efficacy to fulfill the need for cognitive closure (EFNC), which affects the use of cognitive structuring, as a source of SEA. Results of the study confirm that objective knowledge as well as a cognitive-motivational epistemic process (interaction between NFC and EFNC) affect SEA. For high EFNC individuals, the effect of NFC on SEA was positive. However, for low EFNC individuals, the relationship was negative