Closed-loop Frequency Tracking and Rejection

This paper develops an adaptive controller for active vibration control. The method is based on the LQG approach via disturbance modelling given in De Nicolao [1]. This approach to the narrow band disturbance rejection problem is then applied to the problem of eliminating the effects of roll eccentricity in steelstrip rolling mills

Canine giardiosis in Sardinia Island, Italy: prevalence, molecular characterization, and risk factors

Introduction: The flagellate protozoan Giardia duodenalis causes infection in humans and in various animals. Eight distinct assemblages (A-H) have been identified within G. duodenalis; assemblages A and B are those specific to humans and animals, and assemblages C to H are restricted to animal hosts. Methodology: The present study estimated the prevalence of G. duodenalis assemblages in dogs living in the Sardinia region and evaluated the related risk factors. Individual fecal samples were collected from 655 dogs between January 2007 and December 2010, and a form was filled out for each animal to analyze historic data that were available at the time of sampling. Fecal samples were subjected to microscopic and genetic investigations. Results: Cysts of G. duodenalis were found in 172 (26.3%) samples, with significant values in puppies between three and nine months of age, and in kennelled and hunting dogs. The molecular characterization showed the presence of assemblages D (49%), C (36.1%), and subtype A2 (4.2%). Conclusion: The present survey contributes to the knowledge of the occurrence of canine giardiosis in Italy in a region with a high number of dogs and numerous animal movements, which is especially relevant for touristic reasons.</br

HERITAGE 2022 - International Conference on Vernacular Heritage: Culture, People and Sustainability

The study of the hydraulic factories (mills, forges, trip hammers, etc.) of the Valle Sabbia, conducted by a University of Brescia research group, within the "Resilient Valleys" project (funded by the Cariplo Foun-dation), led to the definition of a protocol or guidelines with the ambition of identifying shared and adequate codes of practice to guarantee the correct recovery of this heritage. The object of the survey are artefacts located in functional positions for production activities, today often isolated and not very accessible. The architectural structure and construction features make them particularly vulnerable to deterioration, mo-reso than other types of artefacts. What remains of this building heritage is much closer to the conditions of a ruin which, if recovered or simply maintained, could very effectively convey some of the most charac-teristic features of local economic history. To conserve and maintain this heritage, operational indications and good practice suggestions are proposed, useful in interventions on buildings and hydraulic artefacts. There is neither a compendium with recipes to follow step by step nor even exemplary models, but rather a critical path method that starts from the direct and physical knowledge of the heritage, to arrive at the timely and most suitable conservation intervention. Method suggestions are proposed, which aim to help the owners, users or managers of these architectures, in choosing, within a scenario of traditional and innovative construction techniques available, the most suitable and correct ones to guarantee respect for the buildings’ and hydraulic works’ characteristics, their constructive, morphological, technological, ma-terial peculiarities and, therefore, to monitor and/or solve problems of decay and instability. Ample space is also dedicated to the planned conservation process, in which enhancement will contribute to respecting the material and intellectual integrity of the ruin

NEW PERSPECTIVES FOR MAPPING ALTERATIONS IN HBIM IN CONSERVATION PROJECTS

Historic Building Information Modelling (HBIM) finds one of its most interesting applications in conservation design. The HBIM approach did not originate as a simple data archive method but as an information tool to help the designer at all stages of the building process. Turning to the field of preservation, a lot of information about the building is represented by thematic maps. They make it possible to get a graphic representation of the state of conservation of a facade or to understand the structural situation of a building. This research, experimented on the Arch of Augustus in Aosta, starts from the large amount of data acquired by the RAVA Laboratory of the Superintendence of Aosta over a long period. These data allowed for testing different approaches to thematic mapping, depending on the specific themes to be represented. In any case, even this experimentation required theoretical reasoning that preceded the operational phases. The question, which this article wants only to start to address, concerns the role of thematic mappings in the preservation project carried out with an HBIM approach, their necessity, and their implementation towards truly threedimensional data, which therefore maintains all the information that is directly acquired in three dimensions

NEWPERS PECTIVES FOR MAPPING ALTERATIONS IN HBIMIN CONSERVATION PROJECTS

Historic Building Information Modelling (HBIM) finds one of its most interesting applications in conservation design. The HBIMapproachdid not originate as a simple data archive method but as an information tool to help the designer at all stages of the building process. Turning to the field of preservation, a lot of information about the building is represented by thematic maps. They makeit possible to get a graphic representation of the state of conservation of a facade or to understand the structural situation of a building. This research, experimented on the Arch of Augustus in Aosta, starts from the large amount of data acquired by the RAVA Laboratory of the Superintendence of Aosta over a long period. These data allowed for testing different approaches to thematic mapping, depending on the specific themes to be represented. In any case, even this experimentation required theoretical reasoning that preceded the operational phases. The question, which this article wants only to start to address, concerns the role of thematic mappings in the preservation project carried out with an HBIM approach, their necessity, and their implementation towards truly threedimensional data, which therefore maintains all the information that is directly acquired in three dimensions

Guidelines for the conservation of the ancient hydraulic mills of the Valle Sabbia, Brescia, (Italy)

[EN] The study of the hydraulic factories (mills, forges, trip hammers, etc.) of the Valle Sabbia, conducted by a University of Brescia research group, within the "Resilient Valleys" project (funded by the Cariplo Foundation), led to the definition of a protocol or guidelines with the ambition of identifying shared and adequate codes of practice to guarantee the correct recovery of this heritage. The object of the survey are artefacts located in functional positions for production activities, today often isolated and not very accessible. The architectural structure and construction features make them particularly vulnerable to deterioration, moreso than other types of artefacts. What remains of this building heritage is much closer to the conditions of a ruin which, if recovered or simply maintained, could very effectively convey some of the most characteristic features of local economic history. To conserve and maintain this heritage, operational indications and good practice suggestions are proposed, useful in interventions on buildings and hydraulic artefacts. There is neither a compendium with recipes to follow step by step nor even exemplary models, but rather a critical path method that starts from the direct and physical knowledge of the heritage, to arrive at the timely and most suitable conservation intervention. Method suggestions are proposed, which aim to help the owners, users or managers of these architectures, in choosing, within a scenario of traditional and innovative construction techniques available, the most suitable and correct ones to guarantee respect for the buildings’ and hydraulic works’ characteristics, their constructive, morphological, technological, material peculiarities and, therefore, to monitor and/or solve problems of decay and instability. Ample space is also dedicated to the planned conservation process, in which enhancement will contribute to respecting the material and intellectual integrity of the ruin. Scala, B.; Aliverti, L. (2022). Guidelines for the conservation of the ancient hydraulic mills of the Valle Sabbia, Brescia, (Italy). Editorial Universitat Politècnica de València. 921-928. https://doi.org/10.4995/HERITAGE2022.2022.1526192192

THE ARCH OF AUGUSTUS IN AOSTA: DATA AND ANALYSIS REUSE FOR A CONSERVATION PROJECT

The paper proposes a path for the management of the Arch of Augustus in Aosta to exploit the potential of Historic Building Information Modelling (HBIM). The HBIM system acts both as a place where to georeference the available data and as a tool for the elaboration of the conservation project in all its aspects. The system deals with different data from the survey of geometries to that of materials and alterations, up to the conservation project (mainly focused on the surfaces, with the aim of traceability of the events that the monument has lived, lives, and will live). The challenges in this research concern several aspects. First, it will be necessary to adapt the regular geometry of the BIM approach to the complex shapes necessary for the reproduction of surface alterations in the Puddinga stone. In addition, even more important, the ability to manage the monitoring data distributed at different times, comparing and making them available to current and future restorers (and other operators involved in the preservation). These tasks will be fixed by drawing up a dynamic conservation project, i.e. one that can make use of the available data at any time and all those that will become available during the work. Attempts of data digitization to give a shared value to the conservation activities had already been proposed in the past. The new research now starts from the reconnaissance of the weaknesses of the previous proposals, mainly related to the use of tailor-made systems (software) that are difficult to maintain, to implement and use in a very heterogeneous team of operators (architects, archaeologists, engineers, topographers, chemists, historians…

Genome-wide mapping of 8-oxo-7,8-dihydro-2'-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells

8-Oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) is one of the major DNA modifications and a potent pre-mutagenic lesion prone to mispair with 2- deoxyadenosine (dA). Several thousand residues of 8-oxodG are constitutively generated in the genome of mammalian cells, but their genomic distribution has not yet been fully characterized. Here, by using OxiDIP-Seq, a highly sensitive methodology that uses immuno-precipitation with efficient anti– 8-oxodG antibodies combined with high-throughput sequencing, we report the genome-wide distribution of 8-oxodG in human non-tumorigenic epithelial breast cells (MCF10A), and mouse embryonic fibroblasts (MEFs). OxiDIP-Seq revealed sites of 8- oxodG accumulation overlapping with H2AX ChIPSeq signals within the gene body of transcribed long genes, particularly at the DNA replication origins contained therein. We propose that the presence of persistent single-stranded DNA, as a consequence of transcription-replication clashes at these sites, determines local vulnerability to DNA oxidation and/or its slow repair. This oxidatively-generated damage, likely in combination with other kinds of lesion, might contribute to the formation of DNA double strand breaks and activation of DNA damage response

Il cantiere di conservazione: quali contributi nella ricerca disciplinare?

The paper aims to deepen the close relationship that exists between professional activity and research in conservation projects and sites. These two dimensions of the profession of the architect are tightly tied and necessary the one to the other. Collaboration on the daily problems of design and construction and the resources offered by research institutes is an exemplary synergy of mutual development, which promotes updating and enhances the quality of the two sectors. This makes the link between the University and the professional world less incisive and constructive. For the discipline of conservation this is a problem not only to the detriment of recent graduates, but to the detriment of the protected good. Thanks to the successful consultation with workers in the conservation sector, some students were involved in the visit of construction sites. The validity of the direct experiences offered was highlighted and as moments of confrontation with entrepreneurs and professionals they represent a good practice to be supported