I\u27m Sitting by the Stile Mary

I\u27m sitting by the stile Mary where we sat side by side,On a bright May morning long ago when first you were my bride;The corn was springing fresh and green and the lark sang loud and high,And the red was on your lip Mary and the love light in your eye.The place is little chang\u27d Mary the day is bright as then,The lark\u27s loud song is in my ear and the corn is green again;But I miss the soft clasp of your hand and the breath warm on your cheek,And I still keep list\u27ning to the words you never more may speak, you never more may speak. I\u27m very lonely now Mary for the poor make no new friendsBut oh they love the better still the few our father sends;And you were all I had Mary my blessing and my pride There\u27s nothing left to care for now since my poor Mary died. Bidding you along farewell my Mary kind and true,But I\u27ll not forget you darling in the land I\u27m going to;They say there\u27s bread and work for all and the sun shines always there,But I\u27ll ne\u27er forget old Ireland were it fifty times as fair, were it fifty times as fair

Negative correlation between circulating Cd4⁺Foxp3⁺Cd127⁻ regulatory T Cells and subsequent antibody responses to infant measles vaccine but not diphtheria–tetanus–pertussis vaccine implies a regulatory role

Regulatory T cells (Tregs) play a key homeostatic role by suppressing immune responses. They have been targeted in mouse and human cancer studies to improve vaccine immunogenicity and tumor clearance. A number of commercially available drugs and experimental vaccine adjuvants have been shown to target Tregs. Infants have high numbers of Tregs and often have poor responses to vaccination, yet the role Tregs play in controlling vaccine immunogenicity has not been explored in this age group. Herein, we explore the role of CD4+FOXP3+CD127− Tregs in controlling immunity in infant males and females to vaccination with diphtheria–tetanus–whole cell pertussis (DTP) and/or measles vaccine (MV). We find correlative evidence that circulating Tregs at the time of vaccination suppress antibody responses to MV but not DTP; and Tregs 4 weeks after DTP vaccination may suppress vaccine-specific cellular immunity. This opens the exciting possibility that Tregs may provide a future target for improved vaccine responses in early life, including reducing the number of doses of vaccine required. Such an approach would need to be safe and the benefits outweigh the risks, thus further research in this area is required.</p

A Christmas Cake in Four Quarters

London and New York: Macmillan and Co., 187

The sun is in the West : ballad /

Mode of access: Internet

Colonial memories /

Mode of access: Internet

Travelling about over new and old ground,

"List of books consulted": p. [vii]pt.1. Australasia.--pt.2. North America.--pt.3. South America.--pt.4. Africa.--pt.5. Asia.Mode of access: Internet

A year's housekeeping in South Africa.

Published also in America under titles, "Letters from South Africa" and "Life in South Africa."Mode of access: Internet