Metastable states in a class of long-range Hamiltonian systems

We numerically show that metastable states, similar to the Quasi Stationary States found in the so called Hamiltonian Mean Field Model, are also present in a generalized model in which $N$ classical spins (rotators) interact through ferromagnetic couplings decaying as $r^{-\alpha}$, where $r$ is their distance over a regular lattice. Scaling laws with $N$ are briefly discussed.Comment: Latex 2e, 11 pages, 3 eps figures, contributed paper to the conf. "NEXT 2001", 23-30 May 2001, Cagliari (Italy), submitted to Physica

New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives

Light is known to excite photosensitizers (PS) to produce cytotoxic reactive oxygen species (ROS) in the presence of oxygen. This modality is attractive for designing control measures against animal diseases and pests. Many PS have a proven safety record. Also, the ROS cytotoxicity selects no resistant mutants, unlike other drugs and pesticides. Photodynamic therapy (PDT) refers to the use of PS as light activable tumoricides, microbicides and pesticides in medicine and agriculture.Here we describe "photodynamic vaccination" (PDV) that uses PDT-inactivation of parasites, i.e. Leishmania as whole-cell vaccines against leishmaniasis, and as a universal carrier to deliver transgenic add-on vaccines against other infectious and malignant diseases. The efficacy of Leishmania for vaccine delivery makes use of their inherent attributes to parasitize antigen (vaccine)-presenting cells. Inactivation of Leishmania by PDT provides safety for their use. This is accomplished in two different ways: (i) chemical engineering of PS to enhance their uptake, e.g. Si-phthalocyanines; and (ii) transgenic approach to render Leishmania inducible for porphyrinogenesis. Three different schemes of Leishmania-based PDV are presented diagrammatically to depict the cellular events resulting in cell-mediated immunity, as seen experimentally against leishmaniasis and Leishmania-delivered antigen in vitro and in vivo. Safety versus efficacy evaluations are under way for PDT-inactivated Leishmania, including those further processed to facilitate their storage and transport. Leishmania transfected to express cancer and viral vaccine candidates are being prepared accordingly for experimental trials.We have begun to examine PS-mediated photodynamic insecticides (PDI). Mosquito cells take up rose bengal/cyanosine, rendering them light-sensitive to undergo disintegration in vitro, thereby providing a cellular basis for the larvicidal activity seen by the same treatments. Ineffectiveness of phthalocyanines and porphyrins for PDI underscores its requirement for different PS. Differential uptake of PS by insect versus other cells to account for this difference is under study.The ongoing work is patterned after the one-world approach by enlisting the participation of experts in medicinal chemistry, cell/molecular biology, immunology, parasitology, entomology, cancer research, tropical medicine and veterinary medicine. The availability of multidisciplinary expertise is indispensable for implementation of the necessary studies to move the project toward product development

Expanding ART for Treatment and Prevention of HIV in South Africa: Estimated Cost and Cost-Effectiveness 2011-2050

Background: Antiretroviral Treatment (ART) significantly reduces HIV transmission. We conducted a cost-effectiveness analysis of the impact of expanded ART in South Africa. Methods: We model a best case scenario of 90% annual HIV testing coverage in adults 15-49 years old and four ART eligibility scenarios: CD4 count <200 cells/mm3(current practice), CD4 count <350, CD4 count <500, all CD4 levels. 2011-2050 outcomes include deaths, disability adjusted life years (DALYs), HIV infections, cost, and cost per DALY averted. Service and ART costs reflect South African data and international generic prices. ART reduces transmission by 92%. We conducted sensitivity analyses. Results: Expanding ART to CD4 count <350 cells/mm3prevents an estimated 265,000 (17%) and 1.3 million (15%) new HIV infections over 5 and 40 years, respectively. Cumulative deaths decline 15%, from 12.5 to 10.6 million; DALYs by 14% from 109 to 93 million over 40 years. Costs drop $504 million over 5 years and$3.9 billion over 40 years with breakeven by 2013. Compared with the current scenario, expanding to <500 prevents an additional 585,000 and 3 million new HIV infections over 5 and 40 years, respectively. Expanding to all CD4 levels decreases HIV infections by 3.3 million (45%) and costs by $10 billion over 40 years, with breakeven by 2023. By 2050, using higher ART and monitoring costs, all CD4 levels saves$0.6 billion versus current; other ART scenarios cost $9-194 per DALY averted. If ART reduces transmission by 99$17.5 billion. Sensitivity analyses suggest that poor retention and predominant acute phase transmission reduce DALYs averted by 26% and savings by 7%. Conclusion: Increasing the provision of ART to <350 cells/mm3 may significantly reduce costs while reducing the HIV burden. Feasibility including HIV testing and ART uptake, retention, and adherence should be evaluated

Issues and facilities unique to the nuclear industry - Thermal-hydraulics

Thermal-hydraulics is one of the fundamental disciplines for the design and the operation of water cooled nuclear reactors. Achieving large core power densities requires deep understanding of thermal-hydraulics. Thermal hydraulics became one of the main nuclear safety disciplines when postulated accidents like the Loss-of-Coolant Accident (LOCA) and other thermal-hydraulic transients were identified as the dominant safety concern for LWRs. As full-scale experimentation was not feasible in most situations, significant computational developments had to be undertaken to be able to properly simulate such transients, as needed for the safety case of these reactors. Numerous national and international experimental programmes provided the data necessary for understanding the phenomena and simulating them. The CSNI has always considered with great attention the issue of thermal-hydraulic code validation as well as the experimental database needed for such validation. An overview of the large number of separate-effect and integral test programmes that have been carried out in the past is given in previous SESAR reports.1 2 3 4 The results from these programmes provide a sound basis for model validation of traditional system codes, whereas they are insufficient for multi-dimensional and, especially, for CFD codes. Wide research programs in thermal-hydraulics have been carried out in the period from 70’s to 90’s and contributed to confirm the safety of existing reactors. Once the objectives were achieved, interest and financing towards the related activities dropped down. Several large scale facilities and even laboratories all over the world have been closed or largely reduced their activities. On the one hand, the availability of data from those research programs for future use became difficult or questionable; on the other hand, the expertise of experimentalists leading those programs appears to be lost