Mobilisation: a mode of survival for overlooked minority refugees

Minority refugees and their supporters in Jordan have tried to address the unmet needs of their marginalised communities through daily acts of resistance and informal network-building efforts

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells

Timely characterization of a cancer's evolution is required to predict treatment efficacy and to detect resistance early. High content analysis of single Circulating Tumor Cells (CTCs) enables sequential characterization of genotypic, morphometric and protein expression alterations in real time over the course of cancer treatment. This concept was investigated in a patient with castrate-resistant prostate cancer progressing through both chemotherapy and targeted therapy. In this case study, we integrate across four timepoints 41 genome-wide copy number variation (CNV) profiles plus morphometric parameters and androgen receptor (AR) protein levels. Remarkably, little change was observed in response to standard chemotherapy, evidenced by the fact that a unique clone (A), exhibiting highly rearranged CNV profiles and AR+ phenotype was found circulating before and after treatment. However, clinical response and subsequent progression after targeted therapy was associated with the drastic depletion of clone A, followed by the sequential emergence of two distinct CTC sub-populations that differed in both AR genotype and expression phenotype. While AR- cells with flat or pseudo-diploid CNV profiles (clone B) were identified at the time of response, a new tumor lineage of AR+ cells (clone C) with CNV altered profiles was detected during relapse. We showed that clone C, despite phylogenetically related to clone A, possessed a unique set of somatic CNV alterations, including MYC amplification, an event linked to hormone escape. Interesting, we showed that both clones acquired AR gene amplification by deploying different evolutionary paths. Overall, these data demonstrate the timeframe of tumor evolution in response to therapy and provide a framework for the multi-scale analysis of fluid biopsies to quantify and monitor disease evolution in individual patients

Mapping Digital Media: Jordan

The Mapping Digital Media project examines the global opportunities and risks created by the transition from traditional to digital media. Covering 60 countries, the project examines how these changes affect the core democratic service that any media system should provide: news about political, economic, and social affairs.With high levels of education and literacy, and a youthful population, Jordan is well-placed to explore the opportunities of digital media. Momentum for political reform was catalyzed by the regional uprisings in 2011, prompting modest concessionary measures by the authorities but also a reactionary crackdown on media freedom, with a particular focus on the internet.Television, however, remains the only universal medium in Jordan, and the past decade has seen a dramatic shift in favor of satellite as the dominant viewing platform. This has brought regional and global news providers (such as Al Jazeera), along with hundreds of other free-to-air channels, into over 90 percent of households.Digital switch-over will have little impact against this backdrop. This may explain why the authorities have been slow to prepare for the transition. At the time of writing this report, there are still no publicly available plans for switch-over, despite Jordan's international commitment to turn off analog signals by 2015

High-Throughput Single-Cell Copy Number Profiling for Cancer Heterogeneity Analysis

Intra-tumoral genetic heterogeneity has long been recognized, yet remains poorly understood. This has primarily been due to the lack of sensitive technologies to measure it. Genome wide analysis at the level of single cells has recently emerged as a powerful tool to dissect cancer genome heterogeneity. However, to be truly transformative, single cell approaches must accommodate the analysis of large numbers of single cells. Here, using integrative informatics and molecular biology approaches this study presents a robust, low-cost, and high-throughput method to retrieve the genome-wide copy number landscape of hundreds of single cancer cells. Application of the method to human cancer cell lines and clinical cancer tissue illustrates the underlying genetic heterogeneity present in both and further reveals mosaicism of chromosomal amplifications in clinical cancer samples. The capacity of the method to facilitate the rapid profiling of hundreds and thousands of single cell genomes is bound to illuminate the biology of intra-tumoral heterogeneity. | 99 page

Pengaruh Halal Lifestyle, Halal Awareness dan Halal Branding terhadap Keputusan Pembelian Masyarakat di Kota Makasssar dengan Halal Literacy sebagai Variabel Moderating

Hasil penelitian ini menunjukkan bahwa halal lifestyle berpengaruh negatif namun signifikan terhadap keputusan pembelian masyarakat di Kota Makassar, sementara halal awareness dan halal branding berpengaruh postif dan signifikan terhadap keputusan pembelian masyarakat di Kota Makassar. Adapun halal literacy memperlemah hubungan antara halal lifestyle terhadap keputusan pembelian. adapun literasi halal memperkuat hubungan antara halal awareness terhadap keputusan pembelian masyarakat di Kota Makassar namun tidak signifikan, sementara halal literacy memperkuat hubungan antara halal branding terhadap keputusan pembelian masyarakat di Kota Makassar berpengaruh singnifikan. Implikasi pada penelitian ini bahwa masyarakat di Kota Makassar harusnya dapat lebih menyadari bahwa mengkonsumsi makanan dan minuman halal lagi thayyib merupakan hal yang sangat penting untuk diperhatikan. Selain karena agama mewajibkan, hal ini juga berdampak pada kesehatan. Saat inilah peran pemerintah sangat dibutuhkan, bagaimana mengayomi dan menangkap peluang agar masyarakat mampu dan mau memperhatikan makanan dan minuman yang dikonsumsi. Keputusan pembelian dapat dilihat dari berbagai variabel pendukung, sehingga diharapkan pada penelitian berikutnya dapat mengkaji variabel-variabel lain yang mempengaruhi masyarakata di Kota Makassar dalam keputusan pembelian produk halal

Movilización: una forma de supervivencia para las minorías ignoradas de refugiados: Mobilisation: a mode of survival for overlooked minority refugees

Las minorías de refugiados y sus defensores en Jordania han intentado abordar las necesidades insatisfechas de sus comunidades marginadas mediante actos diarios de resistencia y esfuerzos informales de creación de redes. Minority refugees and their supporters in Jordan have tried to address the unmet needs of their marginalised communities through daily acts of resistance and informal network-building efforts

La mobilisation : un mode de survie pour les réfugiés des minorités oubliées: Mobilisation: a mode of survival for overlooked minority refugees

Les réfugiés issus de minorités et les personnes qui les soutiennent en Jordanie ont tenté de répondre aux besoins non satisfaits de leurs communautés marginalisées par des actes de résistance quotidiens et des efforts de création de réseaux informels. Minority refugees and their supporters in Jordan have tried to address the unmet needs of their marginalised communities through daily acts of resistance and informal network-building efforts

Movilización: una forma de supervivencia para las minorías ignoradas de refugiados

Las minorías de refugiados y sus defensores en Jordania han intentado abordar las necesidades insatisfechas de sus comunidades marginadas mediante actos diarios de resistencia y esfuerzos informales de creación de redes

التعبئة: طريقة للبقاء على قيد الحياة للاجئين من الأقليات المُهمَلة: Mobilisation: a mode of survival for overlooked minority refugees

حاول اللاجئون من الأقليات وأنصارهم في الأردن التعاطي مع الاحتياجات غير الملباة لمجتمعاتهم المهمشة من خلال أعمال المقاومة اليومية وجهود بناء الشبكات غير الرسمية. Minority refugees and their supporters in Jordan have tried to address the unmet needs of their marginalised communities through daily acts of resistance and informal network-building efforts

ANALISIS DAMPAK PENAMBANGAN PASIR TERHADAP SOSIAL EKONOMI DAN LINGKUNGAN MASYARAKAT DI KELURAHAN NOLING KABUPATEN LUWU

Skiripsi ini membahas tentang Dampak dari Penambangan Pasir Terhadap Sosial Ekonomi dan Lingkungan Masyarakat (Studi Kasus di Kelurahan Noling Kabupaten Luwu). Tujuan penelitian ini guna untuk mengetahui:1.) Bagaimana Proses Penambangan Pasir di Kelurahan Noling Kabupaten Luwu, 2.) Bagaimana Dampak Penambangan Pasir Terhadap Sosial Ekonomi dan Lingkungan Masyarakat di Kelurahan Noling Kabupaten Luwu. Jenis Penelitian ini penelitian Kualitatif Deskriptif dan teknik pengumpulan data pada penelitian ini ada dua yaitu teknik pengumpulan dengan cara penelitian kepustakaan dan penelitian lapangan dengan cara observasi, wawancara, dan dokumentasi. Sumber data pada penelitian ini ada dua yaitu data primer dan data sekunder. Data primer diperoleh dari pemilik tambang, kepala kelurahan, masyarakat kelurahan noling, pekerja tambang, dan pemilik warung yang ada di sungai Noling. Sedangkan data sekunder diperoleh dari buku-buku, jurnal dan penelitian terdahulu yang relevan. Analisis data pada penelitian ini menggunakan reduksi data, penyajian data dan menarik kesimpulan. Hasil penelitian ini menunjukkan bahwa: 1.) proses penambangan pasir yang terdiri dari persiapan lokasi, proses perizinan, Jalur akses, pengangkutan pasir dan penjualan pasir. 2.) Dampak penambangan bagi sosial: terbukanya lapangan pekerjaan, pembenahan tempat ibadah, dan ketidak nyamanan masyarakat. Dampak penambangan bagi ekonomi seperti: kenaikan pendapatan pedagang atau pemilik warung, kenaikan pendapatan pekerja las, dan pendapatan masyarakat lokal yang ikut serta dalam penambagan. Dampak bagi lingkungan seperti: pembenahan jalan, kerusakan jalan penurunan kualitas udara, terjadinya erosi, menurunnya kualitas air, tanah dan ancaman terhadap kebun atau lahan masyarakat di sekitar area penambangan. Kata Kunci : Dampak Penambangan pasir, Sosial , Ekonomi, Lingkungan