Representations and Properties of Generalized ArA_r Statistics

A generalization of $A_r$ statistics is proposed and developed. The generalized $A_r$ quantum statistics is completely specified by a set of Jacobson generators satisfying a set of triple algebraic relations. Fock-Hilbert representations and Bargmann-Fock realizations are derived.Comment: 12 pages, to appear in IJMPA (2006

Calculation of some determinants using the s-shifted factorial

Several determinants with gamma functions as elements are evaluated. This kind of determinants are encountered in the computation of the probability density of the determinant of random matrices. The s-shifted factorial is defined as a generalization for non-negative integers of the power function, the rising factorial (or Pochammer's symbol) and the falling factorial. It is a special case of polynomial sequence of the binomial type studied in combinatorics theory. In terms of the gamma function, an extension is defined for negative integers and even complex values. Properties, mainly composition laws and binomial formulae, are given. They are used to evaluate families of generalized Vandermonde determinants with s-shifted factorials as elements, instead of power functions.Comment: 25 pages; added section 5 for some examples of application

Brainstem atrophy in focal epilepsy destabilizes brainstem-brain interactions: Preliminary findings.

BACKGROUND: MR Imaging has shown atrophy in brainstem regions that were linked to autonomic dysfunction in epilepsy patients. The brainstem projects to and modulates the activation state of several wide-spread cortical/subcortical regions. The goal was to investigate 1. Impact of brainstem atrophy on gray matter connectivity of cortical/subcortical structures and autonomic control. 2. Impact on the modulation of cortical/subcortical functional connectivity. METHODS: 11 controls and 18 patients with non-lesional focal epilepsy (FE) underwent heart rate variability (HRV) measurements and a 3 T MRI (T1 in all subjects, task-free fMRI in 7 controls/ 12 FE). The brainstem was extracted, and atrophy assessed using deformation-based-morphometry. The age-corrected z-scores of the mean Jacobian determinants were extracted from 71 5x5x5 mm grids placed in brainstem regions associated with autonomic function. Cortical and non-brainstem subcortical gray matter atrophy was assessed with voxel-based-morphometry and mean age corrected z-scores of the modulated gray matter volumes extracted from 380 cortical/subcortical rois. The profile similarity index was used to characterize the impact of brainstem atrophy on gray matter connectivity. The fMRI was preprocessed in SPM12/Conn17 and the BOLD signal extracted from 398 ROIs (16 brainstem). A dynamic task-free analysis approach was used to identify activation states. Connectivity HRV relationship were assessed with Spearman rank correlations. RESULTS: HRV was negatively correlated with reduced brainstem right hippocampus/parahippocampus gray matter connectivity in controls (p \u3c .05, FDR) and reduced brainstem to right parietal cortex, lingual gyrus, left hippocampus/amygdala, parahippocampus, temporal pole, and bilateral anterior thalamus connectivity in FE (p \u3c .05, FDR). Dynamic task-free fMRI analysis identified 22 states. The strength of the functional brainstem/cortical connectivity of state 15 was negatively associated with HRV (r = -0.5, p = .03) and positively with decreased brainstem-cortical (0.49, p = .03) gray matter connectivity. CONCLUSION: The findings of this small pilot study suggest that impaired brainstem-cortex gray matter connectivity in FE negatively affects the brainstem\u27s ability to control cortical activation

Nonlinear Integral-Equation Formulation of Orthogonal Polynomials

The nonlinear integral equation P(x)=\int_alpha^beta dy w(y) P(y) P(x+y) is investigated. It is shown that for a given function w(x) the equation admits an infinite set of polynomial solutions P(x). For polynomial solutions, this nonlinear integral equation reduces to a finite set of coupled linear algebraic equations for the coefficients of the polynomials. Interestingly, the set of polynomial solutions is orthogonal with respect to the measure x w(x). The nonlinear integral equation can be used to specify all orthogonal polynomials in a simple and compact way. This integral equation provides a natural vehicle for extending the theory of orthogonal polynomials into the complex domain. Generalizations of the integral equation are discussed.Comment: 7 pages, result generalized to include integration in the complex domai

The von Neumann-Wigner type potentials and the wave functions' asymptotics for the discrete levels in continuum

One to one correspondence between the decay law of the von Neumann-Wigner type potentials and the asymptotic behaviour of the wave functions representing bound states in the continuum is established.Comment: latex, 7 page

Virtual patient design : exploring what works and why : a grounded theory study

Objectives: Virtual patients (VPs) are online representations of clinical cases used in medical education. Widely adopted, they are well placed to teach clinical reasoning skills. International technology standards mean VPs can be created, shared and repurposed between institutions. A systematic review has highlighted the lack of evidence to support which of the numerous VP designs may be effective, and why. We set out to research the influence of VP design on medical undergraduates. Methods: This is a grounded theory study into the influence of VP design on undergraduate medical students. Following a review of the literature and publicly available VP cases, we identified important design properties. We integrated them into two substantial VPs produced for this research. Using purposeful iterative sampling, 46 medical undergraduates were recruited to participate in six focus groups. Participants completed both VPs, an evaluation and a 1-hour focus group discussion. These were digitally recorded, transcribed and analysed using grounded theory, supported by computer-assisted analysis. Following open, axial and selective coding, we produced a theoretical model describing how students learn from VPs. Results: We identified a central core phenomenon designated ‘learning from the VP’. This had four categories: VP Construction; External Preconditions; Student–VP Interaction, and Consequences. From these, we constructed a three-layer model describing the interactions of students with VPs. The inner layer consists of the student's cognitive and behavioural preconditions prior to sitting a case. The middle layer considers the VP as an ‘encoded object’, an e-learning artefact and as a ‘constructed activity’, with associated pedagogic and organisational elements. The outer layer describes cognitive and behavioural change. Conclusions: This is the first grounded theory study to explore VP design. This original research has produced a model which enhances understanding of how and why the delivery and design of VPs influence learning. The model may be of practical use to authors, institutions and researchers

High orders of Weyl series for the heat content

This article concerns the Weyl series of spectral functions associated with the Dirichlet Laplacian in a $d$-dimensional domain with a smooth boundary. In the case of the heat kernel, Berry and Howls predicted the asymptotic form of the Weyl series characterized by a set of parameters. Here, we concentrate on another spectral function, the (normalized) heat content. We show on several exactly solvable examples that, for even $d$, the same asymptotic formula is valid with different values of the parameters. The considered domains are $d$-dimensional balls and two limiting cases of the elliptic domain with eccentricity $\epsilon$: A slightly deformed disk ($\epsilon\to 0$) and an extremely prolonged ellipse ($\epsilon\to 1$). These cases include 2D domains with circular symmetry and those with only one shortest periodic orbit for the classical billiard. We analyse also the heat content for the balls in odd dimensions $d$ for which the asymptotic form of the Weyl series changes significantly.Comment: 20 pages, 1 figur

Spectra of Field Fluctuations in Braneworld Models with Broken Bulk Lorentz Invariance

We investigate five-dimensional braneworld setups with broken Lorentz invariance continuing the developments of our previous paper (arXiv:0712.1136), where a family of static self-tuning braneworld solutions was found. We show that several known braneworld models can be embedded into this family. Then we give a qualitative analysis of spectra of field fluctuations in backgrounds with broken Lorentz invariance. We also elaborate on one particular model and study spectra of scalar and spinor fields in it. It turns out that the spectra we have found possess very peculiar and unexpected properties.Comment: 30 pages, 8 figures, minor corrections, references added, note adde

Preserving the palaeoenvironmental record in Drylands: Bioturbation and its significance for luminescence-derived chronologies

Luminescence (OSL) dating has revolutionised the understanding of Late Pleistocene dryland activity. However, one of the key assumptions for this sort of palaeoenvironmental work is that sedimentary sequences have been preserved intact, enabling their use as proxy indicators of past changes. This relies on stabilisation or burial soon after deposition and a mechanism to prevent any subsequent re-mobilisation. As well as a dating technique OSL, especially at the single grain level, can be used to gain an insight into post-depositional processes that may distort or invalidate the palaeoenvironmental record of geological sediment sequences. This paper explores the possible impact of bioturbation (the movement of sediment by flora and fauna) on luminescence derived chronologies from Quaternary sedimentary deposits in Texas and Florida (USA) which have both independent radiocarbon chronologies and archaeological evidence. These sites clearly illustrate the ability of bioturbation to rejuvenate ancient weathered sandy bedrock and/or to alter depositional stratigraphies through the processes of exhumation and sub-surface mixing of sediment. The use of multiple OSL replicate measurements is advocated as a strategy for checking for bioturbated sediment. Where significant OSL heterogeneity is found, caution should be taken with the derived OSL ages and further measurements at the single grain level are recommended. Observations from the linear dunes of the Kalahari show them to have no bedding structure and to have OSL heterogeneity similar to that shown from the bioturbated Texan and Florida sites. The Kalahari linear dunes could have therefore undergone hitherto undetected post-depositional sediment disturbance which would have implications for the established OSL chronology for the region