2,117 research outputs found
Spin caloritronics with superconductors: Enhanced thermoelectric effects, generalized Onsager response-matrix, and thermal spin currents
It has recently been proposed and experimentally demonstrated that it is
possible to generate large thermoelectric effects in ferromagnet/superconductor
structures due to a spin-dependent particle-hole asymmetry. Here, we
theoretically show that quasiparticle tunneling between two spin-split
superconductors enhances the thermoelectric response manyfold compared to when
only one such superconductor is used, generating Seebeck coefficients
( mV/K) and figures of merit () far exceeding
the best bulk thermoelectric materials, and also becomes more resilient toward
inelastic scattering processes. We present a generalized Onsager
response-matrix which takes into account spin-dependent voltage and temperature
gradients. Moreover, we show that thermally induced spin currents created in
such junctions, even in the absence of a polarized tunneling barrier, also
become largest in the case where a spin-dependent particle-hole asymmetry
exists on both sides of the barrier. We determine how these thermal spin
currents can be tuned both in magnitude and sign by several parameters,
including the external field, temperature, and the superconducting
phase-difference.Comment: 7 pages, 5 figures. v2: Added several new results, such as the
response matrix for spin-dependent biases and the evaluation of thermal spin
currents. Accepted for publication in Phys. Rev.
StackInsights: Cognitive Learning for Hybrid Cloud Readiness
Hybrid cloud is an integrated cloud computing environment utilizing a mix of
public cloud, private cloud, and on-premise traditional IT infrastructures.
Workload awareness, defined as a detailed full range understanding of each
individual workload, is essential in implementing the hybrid cloud. While it is
critical to perform an accurate analysis to determine which workloads are
appropriate for on-premise deployment versus which workloads can be migrated to
a cloud off-premise, the assessment is mainly performed by rule or policy based
approaches. In this paper, we introduce StackInsights, a novel cognitive system
to automatically analyze and predict the cloud readiness of workloads for an
enterprise. Our system harnesses the critical metrics across the entire stack:
1) infrastructure metrics, 2) data relevance metrics, and 3) application
taxonomy, to identify workloads that have characteristics of a) low sensitivity
with respect to business security, criticality and compliance, and b) low
response time requirements and access patterns. Since the capture of the data
relevance metrics involves an intrusive and in-depth scanning of the content of
storage objects, a machine learning model is applied to perform the business
relevance classification by learning from the meta level metrics harnessed
across stack. In contrast to traditional methods, StackInsights significantly
reduces the total time for hybrid cloud readiness assessment by orders of
magnitude
Современные подходы в диагностике и лечении тромбозов системы нижней полой вены
ТРОМБОЗ ВЕНОЗНЫЙ /ДИАГН /ТЕРПОЛАЯ ВЕНА, НИЖНЯЯТРОМБОЭМБОЛИЯЛЕГОЧНАЯ ЭМБОЛИ
Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1
The clinical and electroencephalographic features of a canine generalized myoclonic epilepsy with photosensitivity and onset in young Rhodesian Ridgeback dogs (6 wk to 18 mo) are described. A fully penetrant recessive 4-bp deletion was identified in the DIRAS family GTPase 1 (DIRAS1) gene with an altered expression pattern of DIRAS1 protein in the affected brain. This neuronal DIRAS1 gene with a proposed role in cholinergic transmission provides not only a candidate for human myoclonic epilepsy but also insights into the disease etiology, while establishing a spontaneous model for future intervention studies and functional characterization
Metabolic mapping by use of high-resolution magic angle spinning1H MR spectroscopy for assessment of apoptosis in cervical carcinomas
Background
High-resolution magic angle proton magnetic resonance spectroscopy (HR1H MAS MRS) provides a broad metabolic mapping of intact tumor samples and allows for microscopy investigations of the samples after spectra acquisition. Experimental studies have suggested that the method can be used for detection of apoptosis, but this has not been investigated in a clinical setting so far. We have explored this hypothesis in cervical cancers by searching for metabolites associated with apoptosis that were not influenced by other histopathological parameters like tumor load and tumor cell density.
Methods
Biopsies (n = 44) taken before and during radiotherapy in 23 patients were subjected to HR MAS MRS. A standard pulse-acquire spectrum provided information about lipids, and a spin-echo spectrum enabled detection of non-lipid metabolites in the lipid region of the spectra. Apoptotic cell density, tumor cell fraction, and tumor cell density were determined by histopathological analysis after spectra acquisition.
Results
The apoptotic cell density correlated with the standard pulse-acquire spectra (p < 0.001), but not with the spin-echo spectra, showing that the lipid metabolites were most important. The combined information of all lipids contributed to the correlation, with a major contribution from the ratio of fatty acid -CH2 to CH3 (p = 0.02). In contrast, the spin-echo spectra contained the main information on tumor cell fraction and tumor cell density (p < 0.001), for which cholines, creatine, taurine, glucose, and lactate were most important. Significant correlations were found between tumor cell fraction and glucose concentration (p = 0.001) and between tumor cell density and glycerophosphocholine (GPC) concentration (p = 0.024) and ratio of GPC to choline (p < 0.001).
Conclusion
Our findings indicate that the apoptotic activity of cervical cancers can be assessed from the lipid metabolites in HR MAS MR spectra and that the HR MAS data may reveal novel information on the metabolic changes characteristic of apoptosis. These changes differed from those associated with tumor load and tumor cell density, suggesting an application of the method to explore the role of apoptosis in the course of the disease
International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy. However, given that the diagnosis requires the exclusion of other differentials for seizures, the parameters for MRI examination should allow the detection of subtle lesions which may not be obvious with existing techniques. In addition, there are several differentials for idiopathic epilepsy in humans, for example some focal cortical dysplasias, which may only apparent with special sequences, imaging planes and/or particular techniques used in performing the MRI scan. As a result, there is a need to standardize MRI examination in veterinary patients with techniques that reliably diagnose subtle lesions, identify post-seizure changes, and which will allow for future identification of underlying causes of seizures not yet apparent in the veterinary literature.
There is a need for a standardized veterinary epilepsy-specific MRI protocol which will facilitate more detailed examination of areas susceptible to generating and perpetuating seizures, is cost efficient, simple to perform and can be adapted for both low and high field scanners. Standardisation of imaging will improve clinical communication and uniformity of case definition between research studies. A 6–7 sequence epilepsy-specific MRI protocol for veterinary patients is proposed and further advanced MR and functional imaging is reviewed
Strongly Coupled Spin, Heat and Charge Currents in Superconducting Hybrids
We study the large thermoelectric effects arising as a result of strongly coupled spin, heat and charge currents in superconducting hybrids theoretically. Two new frameworks for calculating thermoelectric coefficients are presented, one including the possibility of spin-dependent bias application to homogeneously magnetized materials, and the other utilizing the quasiclassical framework allowing for spin-splitting polarizations along more than one axis. The thermoelectric coefficient governing pure thermal spin currents, the Seebeck coefficient S and the thermoelectric figure of merit ZT are all maximized when tunneling is considered to be across an insulating barrier between two Zeeman-split superconducting reservoirs. The disadvantage of such a configuration is the large external magnetic fields which need be applied for the thermoelectric effects to arise. Therefore, we here present results indicating large thermoelectric effects of similar orders of magnitude arising in superconducting hybrids wherein the particle-hole symmetry is broken without the use of large external magnetic fields. Within the low-field material systems studied, all tunneling occurs from the middle of the central layer in a Josephson junction into a normal-metal electrode. The central nanowire in the Josephson junction (i) contains spatially varying magnetization, (ii) is coupled to spin-active interfaces (such as magnetic insulators) or (iii) has intrinsic spin-orbit interaction of Rashba type
Importance of supply chain and fulfillment operations in businesses that offer perishable food products online
This study highlights the importance of logistics when businesses work with an online channel and perishable food products. An online channel not online provides physical products to its consumers but also related services with products quality. Having a defined competitive strategy and knowing what customers want are extremely important elements to success in the market and with products sell online. However, when business decide to work with this channel these are not the only aspect that businesses should take into account, further, they should also manage efficient supply chain operations, fulfillment operations and distribution processes. This thesis investigates the importance of logistics in an online channel that offers perishable food products to final consumers.
This research study was accomplish in two parts: theoretical and empirical. The theoretical part includes a literature study in online channel, customer requirements, food special characteristics, logistics requirements of food products, supply chain management and fulfillment operations. The empirical part consists of two case studies conducted to two Norwegian companies that offer baskets with food products online to end customers.
The main outcome of this study is the creations of a guideline based on information gather from the literature study and from the case companies. This guideline can reveal different aspect that companies working with an online channel can focus on in order to enhance its supply chain and fulfillment operations and maintain a sustainable success in their local market and in new markets when offering perishable food products online to end consumers
Effective Rheology of Bubbles Moving in a Capillary Tube
We calculate the average volumetric flux versus pressure drop of bubbles
moving in a single capillary tube with varying diameter, finding a square-root
relation from mapping the flow equations onto that of a driven overdamped
pendulum. The calculation is based on a derivation of the equation of motion of
a bubble train from considering the capillary forces and the entropy production
associated with the viscous flow. We also calculate the configurational
probability of the positions of the bubbles.Comment: 4 pages, 1 figur
Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at = 5.02 TeV
Two-particle angular correlations between unidentified charged trigger and
associated particles are measured by the ALICE detector in p-Pb collisions at a
nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum
range 0.7 5.0 GeV/ is examined,
to include correlations induced by jets originating from low
momen\-tum-transfer scatterings (minijets). The correlations expressed as
associated yield per trigger particle are obtained in the pseudorapidity range
. The near-side long-range pseudorapidity correlations observed in
high-multiplicity p-Pb collisions are subtracted from both near-side
short-range and away-side correlations in order to remove the non-jet-like
components. The yields in the jet-like peaks are found to be invariant with
event multiplicity with the exception of events with low multiplicity. This
invariance is consistent with the particles being produced via the incoherent
fragmentation of multiple parton--parton scatterings, while the yield related
to the previously observed ridge structures is not jet-related. The number of
uncorrelated sources of particle production is found to increase linearly with
multiplicity, suggesting no saturation of the number of multi-parton
interactions even in the highest multiplicity p-Pb collisions. Further, the
number scales in the intermediate multiplicity region with the number of binary
nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/161
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