S-adenosyl-l-methionine: (S) -7,8,13, 14-tetrahydroberberine--n-methyltransferase, a branch point enzyme in the biosynthesis of benzophenanthridine and protopine alkaloids.

The enzyme which transfers the CH3-group of S-adenosylmethionine to the nitrogen atom of (S)-tetrahydroberberine and (S)-stylopine is found to occur in a number of plant cell cultures originating from species containing alkaloids; it is located at an important branch point in isoquinoline alkaloid biosynthesis

The Bolocam Galactic Plane Survey. XI. Temperatures and Substructure of Galactic Clumps Based on 350 ?M Observations

We present 107 maps of continuum emission at 350 mu m from Galactic molecular clumps. Observed sources were mainly selected from the Bolocam Galactic Plane Survey (BGPS) catalog, with three additional maps covering star-forming regions in the outer Galaxy. The higher resolution of the SHARC-II images (8."5 beam) compared with the 1.1 mm images from BGPS (33"beam) allowed us to identify a large population of smaller substructures within the clumps. A catalog is presented for the 1386 sources extracted from the 350 mu m maps. The color temperature distribution of clumps based on the two wavelengths has a median of 13.3 K and mean of 16.3 +/- 0.4 K, assuming an opacity law index of 1.7. For the structures with good determination of color temperatures, the mean ratio of gas temperature, determined from NH3 observations, to dust color temperature is 0.88 and the median ratio is 0.76. About half the clumps have more than 2 substructures and 22 clumps have more than 10. The fraction of the mass in dense substructures seen at 350 mu m compared to the mass of their parental clump is similar to 0.19, and the surface densities of these substructures are, on average, 2.2 times those seen in the clumps identified at 1.1 mm. For a well-characterized sample, 88 structures (31%) exceed a surface density of 0.2 g cm(-2), and 18 (6%) exceed 1.0 g cm(-2), thresholds for massive star Formation suggested by theorists.National Science Foundation through NSF grant AST-0708403NRAONSF AST-9980846, AST-0206158, AST-1109116Fulbright FellowshipASI, AgenziaSpaziale Italiana I/038/080/0, I/029/12/0national funding agency: CSA (Canada)national funding agency: NAOC (China)national funding agency: CEA (France)national funding agency: ASI (Italy)national funding agency: MCINN (Spain)national funding agency: Stockholm Observatory (Sweden)national funding agency: STFC (UK)national funding agency: NASA (USA)national funding agency: CNES (France)national funding agency: CNRS (France)Astronom

THE ONSET OF MASSIVE STAR FORMATION: THE EVOLUTION OF TEMPERATURE AND DENSITY STRUCTURE IN AN INFRARED DARK CLOUD

We present new NH3 (1, 1), (2, 2), and (4, 4) observations from the Karl G. Jansky Very Large Array compiled with work in the literature to explore the range of conditions observed in young, massive star-forming regions. To sample the effects of evolution independent from those of distance/resolution, abundance, and large-scale environment, we compare clumps in different evolutionary stages within a single infrared dark cloud (IRDC), G32.02+0.06. We find that the early stages of clustered star formation are characterized by dense, parsec-scale filamentary structures interspersed with complexes of dense cores (60 pc) hosting the IRDC, hypothesizing that it may have been shaped by previous generations of massive stars

An evaluation of the Wii Nunchuk as an alternative assistive device for people with intellectual and physical disabilities using switch controlled software

Many people with intellectual disabilities also have physical difficulties which prevent them from using standard computer control devices. Custom made alternative devices for those with special needs can be expensive and the low unit turnover makes the prospect unattractive to potential manufacturers. One solution is to explore the potential of devices used in contemporary gaming technology, such as the Nintendo Wii. The Wii Nunchuk has the potential to replace joystick functions with the advantages of not being surface bound and easier for some individuals to grasp. This study evaluated the feasibility of using the Nunchuk by comparing its performance as a switch with the participant's usual switch. Twenty three volunteers aged between 17 and 21 with intellectual and physical disabilities completed a Single Switch Performance Test using the new device and their familiar device. For most functions of the switch, there was no significant difference between the participants' performance using the Nunchuck and their familiar device. Additional analysis found that some participants' performance did improve whilst using the Nunchuck, but this was not significantly related to physical or cognitive ability. Those whose performance was better with the Nunchuk were more likely to hold it in the conventional way than were those who had better performance with their familiar device. This merits it being offered as a possible alternative to currently available switches for those with physical difficulties affecting their grip

Changing practice to support self-management and recovery in mental illness: application of an implementation model

Author Version made available in accordance with the publisher's policyHealth services introducing practice changes need effective implementation methods. Within the setting of a community mental health service offering recovery-oriented psychosocial support for people with mental illness, we aimed to (a) identify a well-founded implementation model and (b) assess its practical usefulness in introducing a new program for recovery-oriented self-management support. We reviewed the literature to identify implementation models applicable to community mental health, and having corresponding measurement tools. We used one of these models to inform organisational change strategies. The literature review showed few models with corresponding tools. The Promoting Action on Research Implementation in Health Services (PARIHS) model and the related Organizational Readiness to Change Assessment (ORCA) tool were used. PARIHS proposes prerequisites for health service change and the ORCA measures the extent to which these prerequisites are present. Application of the ORCA at two time points during implementation of the new program showed strategy-related gains for some prerequisites but not for others, reflecting observed implementation progress. Additional strategies to address target prerequisites could be drawn from the PARIHS model. The PARIHS model and ORCA tool have potential in designing and monitoring practice change strategies in community mental health. Further practical use and testing of implementation models appears justified in overcoming barriers to change

PROCEE: a PROstate Cancer Evaluation and Education serious game for African Caribbean men

Purpose – Prostate cancer is the most common cancer diagnosed in men in the UK. Black men are in a higher prostate cancer risk group possibly due to inherent genetic factors. The purpose of this paper is to introduce PROstate Cancer Evaluation and Education (PROCEE), an innovative serious game aimed at providing prostate cancer information and risk evaluation to black African-Caribbean men. Design/methodology/approach – PROCEE has been carefully co-designed with prostate cancer experts, prostate cancer patients and members of the black African-Caribbean community in order to ensure that it meets the real needs and expectations of the target audience. Findings – During the co-design process, the users defined an easy to use and entertaining game which can effectively raise awareness, inform users about prostate cancer and their risk, and encourage symptomatic men to seek medical attention in a timely manner. Originality/value – During focus group evaluations, users embraced the game and emphasised that it can potentially have a positive impact on changing user behaviour among high risk men who are experiencing symptoms and who are reluctant to visit their doctor

THE COMPARISON OF PHYSICAL PROPERTIES DERIVED FROM GAS AND DUST IN A MASSIVE STAR-FORMING REGION

We explore the relationship between gas and dust in a massive star-forming region by comparing the physical properties derived from each. We compare the temperatures and column densities in a massive star-forming Infrared Dark Cloud (G32.02+0.05), which shows a range of evolutionary states, from quiescent to active. The gas properties were derived using radiative transfer modeling of the (1,1), (2,2), and (4,4) transitions of NH3 on the Karl G. Jansky Very Large Array, while the dust temperatures and column densities were calculated using cirrus-subtracted, modified blackbody fits to Herschel data. We compare the derived column densities to calculate an NH3 abundance, χ$_{{\rm NH}_{3}}$ = 4.6 × 10–8. In the coldest star-forming region, we find that the measured dust temperatures are lower than the measured gas temperatures (mean and standard deviations T dust, avg ~ 11.6 ± 0.2 K versus T gas, avg ~ 15.2 ± 1.5 K), which may indicate that the gas and dust are not well-coupled in the youngest regions (~0.5 Myr) or that these observations probe a regime where the dust and/or gas temperature measurements are unreliable. Finally, we calculate millimeter fluxes based on the temperatures and column densities derived from NH3, which suggest that millimeter dust continuum observations of massive star-forming regions, such as the Bolocam Galactic Plane Survey or ATLASGAL, can probe hot cores, cold cores, and the dense gas lanes from which they form, and are generally not dominated by the hottest core