Measurements of muon multiple scattering in MICE

Neutrino factories have been identified as the best facility for making precision measurements of neutrino oscillation physics. To fully realize this technology, a demonstration of the reduction of the phase space of a muon beam must be presented. The Muon Ionization Cooling Experiment (MICE) is tasked with providing such a demonstration. Ionization cooling uses the energy loss in a low Z material followed by acceleration in RF cavities to reduce the phase space of a beam on a time scale many times less than the time scale of muon decay. Multiple coulomb scattering (MCS) simultaneously inflates the muon beam and so the interplay between energy loss and MCS must be well understood. Unfortunately MCS is not well simulated in the materials of interest in the GEANT Monte Carlo program. A programme has commenced for MICE to measure MCS in several materials of interest including lithium hydride, liquid hydrogen, and gaseous xenon. The experimental methods and early results will be presented

The Probability Density of the Higgs Boson Mass

The LEP Collaborations have reported a small excess of events in their combined Higgs boson analysis at center of mass energies up to about 208 GeV. In this communication, I present the result of a calculation of the probability distribution function of the Higgs boson mass which can be rigorously obtained if the validity of the Standard Model is assumed. It arises from the combination of the most recent set of precision electroweak data and the current results of the Higgs searches at LEP 2.Comment: 3 pages, 2 figure

Gateway to College: Lessons from Implementing a Rigorous Academic Program for At-Risk Young People

Despite efforts to improve the high school graduation rate in the United States, an estimated 7,200 students drop out of high school every day -- a staggering 1.3 million every year. Further, a recent report by the Center on Education and the Workforce at Georgetown University projects that by 2020, nearly 65 percent of U.S. jobs will require at least some college education, out of reach for those who are unable to earn a high school diploma. Much more comprehensive alternative education programs are needed that put dropouts and students at risk of dropping out on a path to earn high school diplomas while also providing them with the academic skills and support necessary to be successful in their postsecondary pursuits

Pursued by the law: the victimisation of children who offend

"Development work in this field has barely started. Relevant international standards and guidelines are available but remain poorly applied by many nations. Hundreds of thousands of children suffer daily as a result of outdated law, absence of children's legal advocacy services, lack of children's courts and detention centres, poorly trained and resourced policing and inadequate prevention and reintegration programmes. Overseas aid programmes must place these needs within their basket of priorities. It is not, however, simply a matter of law reform and infrastructure. Most basic of all is the urgent need to change community attitudes towards children so that they can urgently receive the social support and reintegration they need in order to enjoy their fundamental human right to live out their childhood protected by the law rather than victimised by it ..." - page

IL-17 can be protective or deleterious in murine pneumococcal pneumonia

Streptococcus pneumoniae is the major bacterial cause of community-acquired pneumonia, and the leading agent of childhood pneumonia deaths worldwide. Nasal colonization is an essential step prior to infection. The cytokine IL-17 protects against such colonization and vaccines that enhance IL-17 responses to pneumococcal colonization are being developed. The role of IL-17 in host defence against pneumonia is not known. To address this issue, we have utilized a murine model of pneumococcal pneumonia in which the gene for the IL-17 cytokine family receptor, Il17ra, has been inactivated. Using this model, we show that IL-17 produced predominantly from γδ T cells protects mice against death from the invasive TIGR4 strain (serotype 4) which expresses a relatively thin capsule. However, in pneumonia produced by two heavily encapsulated strains with low invasive potential (serotypes 3 and 6B), IL-17 significantly enhanced mortality. Neutrophil uptake and killing of the serotype 3 strain was significantly impaired compared to the serotype 4 strain and depletion of neutrophils with antibody enhanced survival of mice infected with the highly encapsulated SRL1 strain. These data strongly suggest that IL-17 mediated neutrophil recruitment to the lungs clears infection from the invasive TIGR4 strain but that lung neutrophils exacerbate disease caused by the highly encapsulated pneumococcal strains. Thus, whilst augmenting IL-17 immune responses against pneumococci may decrease nasal colonization, this may worsen outcome during pneumonia caused by some strains

A simple formula for pooling knowledge about a quantum system

When various observers obtain information in an independent fashion about a classical system, there is a simple rule which allows them to pool their knowledge, and this requires only the states-of-knowledge of the respective observers. Here we derive an equivalent quantum formula. While its realm of applicability is necessarily more limited, it does apply to a large class of measurements, and we show explicitly for a single qubit that it satisfies the intuitive notions of what it means to pool knowledge about a quantum system. This analysis also provides a physical interpretation for the trace of the product of two density matrices.Comment: 5 pages, Revtex

Castleman disease and lymphocytic interstitial pneumonia: a complex diagnostic and management challenge

No abstract available

ST2 and Multimarker Testing in Acute Decompensated Heart Failure

Most data on heart failure biomarkers have been derived from patient cohorts with chronic disease. However, risk prediction in patients admitted with acute decompensated heart failure (ADHF) remains a challenge. ADHF is not a single disease: it presents in various manners, and different causes may underlie ADHF, which may be reflected by different biomarkers. Soluble suppression of tumorigenicity 2 (ST2) has been shown to be a strong independent predictor of short-, mid-, and long-term outcome in ADHF. Furthermore, combining biomarkers may help further improve the prognostic power of ST2. The ProBNP Investigation of Dyspnea in the Emergency Department study showed that elevated plasma levels of ST2 together with elevated levels of 4 other biomarkers have clear incremental values to predict outcome in ADHF. The Multinational Observational Cohort on Acute Heart Failure study is an international collaborative network that recruited 5,306 patients hospitalized for ADHF that demonstrated that ST2 and midregional pro-adrenomedulin had independently strong value to predict 30-day and 1-year outcome in patients with ADHF. The Multinational Observational Cohort on Acute Heart Failure study also showed that C-reactive protein plus ST2 better classified risk in patients with ADHFs than ST2 alone. Combining biomarkers for risk prediction or risk stratification might have clinical and more importantly pathophysiological meaning

Interleukin-17 is required for control of chronic lung infection caused by Pseudomonas aeruginosa

Chronic pulmonary infection with Pseudomonas aeruginosa is a feature of cystic fibrosis (CF) and other chronic lung diseases. Cytokines of the IL-17 family have been proposed as important in the host response to P. aeruginosa infection through augmenting antibacterial immune responses, although their pro-inflammatory effect may contribute to lung damage that occurs as a result of chronic infection. We set out to explore the role of IL-17 in the host response to chronic P. aeruginosa infection. We used a murine model of chronic pulmonary infection with CF-related strains of P. aeruginosa. We demonstrate that IL-17 cytokine signaling is essential for survival and prevention of chronic infection at 2 weeks post-inoculation using two different P. aeruginosa strains. Following infection, there was a marked expansion of cells within mediastinal lymph nodes, comprised mainly of innate lymphoid cells (ILCs); ∼90% of IL-17 producing cells had markers consistent with Group 3 ILCs. A smaller percentage of IL-17+ cells had markers consistent with a B1 phenotype. In lung homogenates 14 days following infection, there was a significant expansion of IL-17+ cells – about 50% of these were CD3+, split equally between CD4+ Th17 cells and γδ T cells, while the CD3- IL-17+ cells were almost exclusively Group 3 ILCs. Further experiments with B cell deficient mice showed that B cell production of IL-17 or natural antibodies did not provide any defence against chronic P. aeruginosa infection. Thus, IL-17 rather than antibody is a key element in host defence against chronic pulmonary infection with P. aeruginosa