1,151 research outputs found
An Overview and Critique of NCAA Policy Regarding the Use of Sport Psychology Consultants at the Division I Level
Over the past 20 years the National Collegiate Athletic Association Division-I (NCAA) has restricted the activities of sport psychology consultants (SPCs) working with student-athletes, particularly at the Division I (D-I) level. In some cases, the restrictions have been based on the assumption that what SPCs do is actually “coaching.” Thus, if SPCs are permitted to interact with student-athletes during practices and competitions they must be considered as “countable” coaches. In this paper, we briefly discuss the history of NCAA rules governing the activities of SPCs, provide excerpts from the sport psychology literature and the NCAA D-I Manual that illustrate how the specialized work of SPCs is different from that of coaches, suggest reasons why allowing student-athletes and coaches access to SPCs during practices and competitions would be beneficial to both groups, and propose ways NCAA legislation might be amended to allow SPCs to work with student-athletes in a manner similar to the ways other athletic department support personnel (e.g., athletic trainers and strength and conditioning coaches) are permitted to do
Inflammation as a Central Mechanism in Alzheimer\u27s Disease
Alzheimer\u27s disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles. Over the last decade, the presence of a sustained immune response in the brain has emerged as a third core pathology in AD. The sustained activation of the brain\u27s resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may serve as a link in the pathogenesis of the disorder. In the following review, we provide an overview of inflammation in AD and a detailed coverage of a number of microglia-related signaling mechanisms that have been implicated in AD. Additional information on microglia signaling and a number of cytokines in AD are also reviewed. We also review the potential connection of risk factors for AD and how they may be related to inflammatory mechanisms
Traumatic brain injury in hTau model mice: Enhanced acute macrophage response and altered long-term recovery
TBI induces widespread neuroinflammation and accumulation of microtubule associated protein tau (MAPT) - two key pathological features of tauopathies. This study sought to characterize the microglial/macrophage response to TBI in genomic-based MAPT transgenic mice in a Mapt knockout background (called hTau). Two-month-old hTau and age-matched control male and female mice received a single lateral fluid percussion TBI or sham injury. Separate groups of mice were aged to an acute (3 days post-injury [DPI]) or chronic (135 DPI) post-injury time point. As judged by tissue immunostaining for macrophage markers, microglial/macrophage response to TBI was enhanced at 3 DPI in hTau mice compared to control TBI and sham mice. However, MAPT phosphorylation increased in hTau mice regardless of injury group. Flow cytometric analysis revealed distinct populations of microglia and macrophages within all groups at 135 DPI. Unexpectedly, microglial reactivity was significantly reduced in hTau TBI mice compared to all other groups. Instead, hTau TBI mice showed a persistent macrophage response. In addition, TBI enhanced MAPT pathology in the temporal cortex and hippocampus of hTau TBI mice compared to controls 135 DPI. A battery of behavioral test revealed that TBI in hTau mice resulted in compromised use of spatial search strategies to complete a water maze task despite lack of motor or visual deficits. Collectively, these data indicate that the presence of wild-type human tau alters the microglial/macrophage response to a single TBI, induces delayed, region-specific MAPT pathology, and alters cognitive recovery; however, the causal relationship between these events remains unclear. These results highlight the potential significance of communication between MAPT and microglia/macrophages following TBI and emphasize the role of neuroinflammation in post-injury recovery
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FIGURED WORLDS: A PHENOMENOLOGICAL STUDY OF COMMUNITY COLLEGE FACULTY LEADERS
Despite the importance of community colleges in higher education, community college faculty are understudied. Although the community college has been defined as a teaching institution, its faculty also serve in non-teaching leadership roles. The purpose of this research study is to know (1) what the experiences of community college faculty in leadership roles are, (2) how their roles have changed over time, (3) what factors motivated faculty to accept non-teaching roles, and (4) how faculty have navigated the transition. Data were obtained from open-ended, semi-structured interviews using an Interpretive Phenomenological approach. Qualitative data were transcribed, coded, categorized, and then organized into five prominent thematic findings: a) Loyalty to the Community College and Students, b) A Student-Centered Collegial Identity, c) Personal Fulfillment, d) Cycle of Roles and e) Tensions. This study informs community college stakeholders about how to strengthen and support faculty leadership at the community college with implications for policy, practice and future research
Child Murder: A Re-examination Of Durkheim\u27s Theory Of Homicide
The current study examines county-level characteristics and their impact on child homicide. This work uses Durkheimian theory and tests the concept of solidarity by using variables that constitute integration and regulation. In addition, some variables are drawn from other theoretical perspectives, mainly social disorganization and anomie theories, to better explore additional macro-level indicators. Data were obtained from multiple locations. Homicide data for children, from birth through five years, utilized in this work came from the National Incident-Based Reporting System. County level socio-demographics were obtained from the Census. Political party affiliation (Republican or Democrat) came from Politico, and religious data were collected by InfoGroup and organized into groups by the Association of Religion Data Archives. This study aims to increase our understanding of how macro-level contextual and situational factors may help guide policy makers, law enforcement personnel, and any other individuals who are concerned with areas where there are varying degrees of risk for child homicid
Restorative Pedagogy to Build Community in the Classroom: Autoethnographic Reflections from Faculty
Restorative justice (RJ) is a philosophy and set of practices that center harms and needs. Within a classroom setting, an RJ pedagogical approach invites a process of shared learning that attends to critical issues of equity, power, and voice. Utilizing an autoethnographic approach, this manuscript includes critical reflections from three faculty members from diverse disciplines and positionalities about the use of RJ approaches to teaching in our respective classrooms. This paper includes discussion about the intersection of RJ with critical pedagogy, power differentials, and pragmatic issues of classroom structure learning design
Alterations to nuclear architecture and genome behavior in senescent cells.
The organization of the genome within interphase nuclei, and how it interacts with nuclear structures is important for the regulation of nuclear functions. Many of the studies researching the importance of genome organization and nuclear structure are performed in young, proliferating, and often transformed cells. These studies do not reveal anything about the nucleus or genome in nonproliferating cells, which may be relevant for the regulation of both proliferation and replicative senescence. Here, we provide an overview of what is known about the genome and nuclear structure in senescent cells. We review the evidence that nuclear structures, such as the nuclear lamina, nucleoli, the nuclear matrix, nuclear bodies (such as promyelocytic leukemia bodies), and nuclear morphology all become altered within growth-arrested or senescent cells. Specific alterations to the genome in senescent cells, as compared to young proliferating cells, are described, including aneuploidy, chromatin modifications, chromosome positioning, relocation of heterochromatin, and changes to telomeres
Restorative Pedagogy to Build Community in the Classroom: Autoethnographic Reflections from Faculty
Restorative justice (RJ) is a philosophy and set of practices that center harms and needs. Within a classroom setting, an RJ pedagogical approach invites a process of shared learning that attends to critical issues of equity, power, and voice. Utilizing an autoethnographic approach, this manuscript includes critical reflections from three faculty members from diverse disciplines and positionalities about the use of RJ approaches to teaching in our respective classrooms. This paper includes discussion about the intersection of RJ with critical pedagogy, power differentials, and pragmatic issues of classroom structure learning design
Navigating Rough Waters: Public Swimming Pools, Discrimination, and the Law
Historically, swimming pools have been a focal point of racial tension. Discrimination and segregation are inextricably tied to the history of public swimming usage in the United States. Pools are public spaces that are physically and visually intimate. History has revealed that both de jure (enacted through the law by the government) and de facto (occurs through social interaction) discrimination have contributed to segregatory practices in the United States. The purpose of this article is twofold: 1) to examine the social pattern of discrimination that has stymied the growth of swimming in communities of color in the United States; and 2) to examine key legal cases that helped to mitigate discriminatory practices in the use of public swimming pools in the United States. Landmark cases such as Plessy v. Ferguson, Brown v. Topeka, and Dawson v. Mayor and City Council of Baltimore each helped to cast a bright light on the practice of segregation and public swimming pools. In spite of the history of discrimination and segregation relative to public swimming pools in the United States, citizens, stakeholder groups and professional associations must be advocates to ensure that public pools are protected and that the patterns of discrimination and “neuvo-segregation” do not persist
Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections
Application of single-molecule switching nanoscopy (SMSN) beyond the coverslip surface poses substantial challenges due to sample-induced aberrations that distort and blur single-molecule emission patterns. We combined active shaping of point spread functions and efficient adaptive optics to enable robust 3D-SMSN imaging within tissues. This development allowed us to image through 30-μm-thick brain sections to visualize and reconstruct the morphology and the nanoscale details of amyloid-β filaments in a mouse model of Alzheimer's disease
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