Effects of alcohol consumption on mortality in patients with Type 2 diabetes mellitus

Aims/hypothesis: Moderate alcohol intake has been associated with increased life expectancy due to reduced mortality from cardiovascular disease. We prospectively examined the effects of alcohol consumption on mortality in Type 2 diabetic patients in Switzerland. Methods: A total of 287 patients with Type 2 diabetes mellitus (125 women, 162 men), recruited in Switzerland for the WHO Multinational Study of Vascular Disease in Diabetes, were included in this study. After a follow-up period of 12.6±0.6 years (means ± SD), mortality from CHD and from all causes was assessed. Results: During the follow-up, 70 deaths occurred (21 from CHD, 49 from other causes). Compared with non-drinkers, alcohol consumers who drank alcohol 1 to 15g, 16 to 30g and 30g or more per day had the following risk rates of death from CHD: 0.87 (95% CI: 0.25 to 2.51, NS), 0.00 (95% CI: 0.00 to 0.92, p less than 0.05) and 0.37 (95% CI, 0.01 to 2.42, NS), respectively. The corresponding risk rates of death from all causes were 1.27 (95% CI: 0.68 to 2.28, NS), 0.36 (95% CI: 0.09 to 0.99, p less than 0.05) and 1.66 (95% CI: 0.76 to 3.33, NS). Conclusions/interpretation: In Swiss Type 2 diabetic patients moderate alcohol consumption of 16 to 30g per day was associated with reduced mortality from CHD and from all causes. Alcohol intake above 30g per day was associated with a tendency towards increased all-cause mortalit

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

Aims/hypothesis: We evaluated the association of QT interval corrected for heart rate (QTc) and resting heart rate (rHR) with mortality (all-causes, cardiovascular, cardiac, and ischaemic heart disease) in subjects with type 1 and type 2 diabetes. Methods: We followed 523 diabetic patients (221 with type 1 diabetes, 302 with type 2 diabetes) who were recruited between 1974 and 1977 in Switzerland for the WHO Multinational Study of Vascular Disease in Diabetes. Duration of follow-up was 22.6 ± 0.6years. Causes of death were obtained from death certificates, hospital records, post-mortem reports, and additional information given by treating physicians. Results: In subjects with type 1 diabetes QTc, but not rHR, was associated with an increased risk of: (1) all-cause mortality (hazard ratio [HR] 1.10 per 10ms increase in QTc, 95% CI 1.02-1.20, p = 0.011); (2) mortality due to cardiovascular (HR 1.15, 1.02-1.31, p = 0.024); and (3) mortality due to cardiac disease (HR 1.19, 1.03-1.36, p = 0.016). Findings for subjects with type 2 diabetes were different: rHR, but not QTc was associated with mortality due to: (1) all causes (HR 1.31 per 10 beats per min, 95% CI 1.15-1.50, p < 0.001); (2) cardiovascular disease (HR 1.43, 1.18-1.73, p < 0.001); (3) cardiac disease (HR 1.45, 1.19-1.76, p < 0.001); and (4) ischaemic heart disease (HR 1.52, 1.21-1.90, p < 0.001). Effect modification of QTc by type 1 and rHR by type 2 diabetes was statistically significant (p < 0.05 for all terms of interaction). Conclusions/interpretation: QTc is associated with long-term mortality in subjects with type 1 diabetes, whereas rHR is related to increased mortality risk in subjects with type 2 diabete

Effects of alcohol consumption on mortality in patients with Type 2 diabetes mellitus

Moderate alcohol intake has been associated with increased life expectancy due to reduced mortality from cardiovascular disease. We prospectively examined the effects of alcohol consumption on mortality in Type 2 diabetic patients in Switzerland

Improving how we use workshops when solving complex research problems: reflections from the CHANGE project

Organising workshops that successfully address complex research problems is a challenge, especially when the research involves interest-holders with diverse roles and expertise and potentially conflicting values and viewpoints. In this article, we describe and reflect on the approach we took to organising the CHANGE workshop, held in Oslo in June 2024. CHANGE is a complex 3-year project involving the collecting, analysing, and developing cross-sector consensus on a challenging topic. The approaches on which we reflect include fundamental aspects of interest-holder engagement, workshop design, methodological approach, and inclusive participation. Based on our reflections, we present a series of recommendations for consideration by anyone in the general research community using workshops as part of a research process

Psychosocial adaptation of adolescent migrants in a Swiss community survey

OBJECTIVE: The aim of this study was to compare psychosocial adaptation in adolescent (first generation) migrants, double-citizens (mainly second generation with one migrant parent), and native Swiss, and to compare migrants from various European regions. METHOD: Data from a community survey were based on 1,239 participants (mean age 13.8, SD = 1.6 years) with 996 natives, 55 double-citizens, and 188 migrants. The adolescents completed the youth self-report measuring emotional and behavioural problems, and various questionnaires addressing life events, personality variables, perceived parental behaviour (PPB), family functioning, school environment, and social network. RESULTS: Adolescent migrants had significantly higher scores for internalizing and externalizing problems. There was a pattern of various unfavourable psychosocial features including life events, coping, self-related cognitions, and PPB that was more common among adolescent migrants than natives. Double-citizens were similar to natives in all domains. Young adolescents from South and South-East Europe differed from natives in terms of more unfavourable psychosocial features. Migrant status was best predicted by adverse psychosocial features rather than emotional and behavioural problems. CONCLUSION: There is some indication that certain migrant adolescents are at risk of psychosocial mal-adaptation. Obviously, ethnic origin is an important moderator

Unmanned aerial vehicle-based mapping of turf-banked solifluction lobe movement and its relation to material, geomorphometric, thermal and vegetation properties

Solifluction is one of the most widespread periglacial processes with low annual movement rates in the range of —millimeters to centimeters. Traditional methods to assess solifluction movement usually have low spatial resolution, which hampers our understanding of spatial movement patterns and the factors controlling them. In this study, we (a) test the applicability of unmanned aerial vehicle (UAV)-based structure-from-motion photogrammetry in comparison to a traditional total station survey to map surface movement of a turf-banked solifluction lobe (TBL) in the Turtmann Valley (Switzerland). We then (b) relate the detected movement patterns to potential geomorphometric, material, thermal and vegetation controls, which we assessed using geomorphic and vegetation mapping, electrical resistivity surveys and temperature loggers. Our results show that (a) UAV-based mapping can detect solifluction movement with high spatial resolution (one point per m2, total > 900 points) and rates and patterns consistent with a total station survey, but requires careful measurement set-up and analysis; and (b) movement rates differ between lobe tread, riser and a ridge feature. Differences can be explained by heterogeneous material, geomorphometric, thermal and vegetation properties of the TBL, which promote different solifluction processes. Our study demonstrates the applicability of UAV-based mapping in solifluction research and improves our understanding of solifluction processes and landform development

Improving how we use workshops when solving complex research problems : reflections from the CHANGE project

Organising workshops that successfully address complex research problems is a challenge, especially when the research involves interest-holders with diverse roles and expertise and potentially conflicting values and viewpoints. In this article, we describe and reflect on the approach we took to organising the CHANGE workshop, held in Oslo in June 2024. CHANGE is a complex 3-year project involving the collecting, analysing, and developing cross-sector consensus on a challenging topic. The approaches on which we reflect include fundamental aspects of interest-holder engagement, workshop design, methodological approach, and inclusive participation. Based on our reflections, we present a series of recommendations for consideration by anyone in the general research community using workshops as part of a research process

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

We evaluated the association of QT interval corrected for heart rate (QT(c)) and resting heart rate (rHR) with mortality (all-causes, cardiovascular, cardiac, and ischaemic heart disease) in subjects with type 1 and type 2 diabetes