Multicomponent Reaction of Benzyl Halides: Synthesis of [1,2,4]triazolo/benzimidazolo Quinazolinones

We demonstrated a simple, highly efficient, one-pot method to construct triazolo/benzimidazolo quinazolinones through a cascade of oxidation, Knoevenagel condensation, and Michael addition followed by cyclization and dehydration. This protocol tolerates easily available benzyl halides, 2-amino benzimidazole/3-amino-1,2,4-triazole, and α-hydroxy C-H acids as starting materials using trimethyl amine N-oxide in ethanol. To the best of our knowledge, this is the first example of synthesis of triazolo/benzimidazolo quinazolinones directly from benzyl halides in one pot. Simple procedure, environmental friendliness, mild reaction conditions, and good yields are the attractive features of this method

Genetic and environmental contributions to the economic characteristics of the Michigan state college dairy heard

Thesis (Ph. D.)--Michigan State College of Agriculture and Applied Science. Department of Animal Husbandry, 1951Includes bibliographical references (pages 196-204

Four Component Synthesis of Highly Functionalized Pyrano[2,3-c]pyrazoles from Benzyl Halides

N-methylmorpholine N-oxide and silver oxide (Ag2O) oxidized four component reaction for the preparation of pyranopyrazole with different substituted pattern have been developed which provides rapid access to a library of compounds in good to excellent yields by using benzyl halide, malanonitrile/ethyl cyanoacetate, diethylacetylenedicarboxylate/ethyl acetoacetate and hydrazine hydrate as reactants. This transformation involves the breaking of one C‒O bond and formation of 2 C–C, 2 C–N, and a C‒O bond leading to the formation of a five and six membered ring in one pot operation

CO-AMORPHOUS FORM OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-A] PYRROLO[2,3-E] PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL) PYRROLIDINE-1-CARBOXAMIDE AND PROCESS FOR ITS PREPARATION THEREOF

Abstract The present invention pertains to co-amorphous form of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide of formula (I) and process for its preparation thereof. The chemical structure of compound of formula (I) is shown below

Impact of Occupational Stress and Its Associated Factors on Cognitive, Hormonal and Stress Responsive Protein in Mining Based Industrial Workers

Rapid globalization and technological advances have transformed the way of working. Occupational stress is psychological and physical condition that has potential to worsen a person’s health in any workplace. Stress related productivity impairment were common in mining industries. Lack of skills, organizational issues, and a social support at workplace can all cause workers to experience stress. Therefore, hypothalamus-pituitary-adrenal (HPA) axis and sympathetic nervous system are activated as part of the body’s physiological reaction. Hence chronic stress were linked to digestive, cardiovascular, atherosclerosis, and neurological issues. Numerous studies reported, several biochemical and pathophysiological factors were responsible for occupational, environmental, and workplace depression. This review chapter were included studied from PubMed, Google, book chapters, case reports, and other electronic databases, etc. Total (n = 104) articles were selected related to occupational stress and its impact on biochemical and pathophysiological were experienced in them. Workers who experienced occupational stress underwent pathophysiological changes that leads to changes in the stress hormones, sensitive stress protein and other significant variables. Finally, cortisol, stress hormones, PTH, HO-1, cytokines used as a panel of marker for stressful conditions evaluation in occupational settings. These findings, advice interventions that will be reduce, or eradicate some of these stressors in occupational settings

Interventions to reduce pesticide exposure from the agricultural sector in Africa: a workshop report

Despite the fact that several cases of unsafe pesticide use among farmers in different parts of Africa have been documented, there is limited evidence regarding which specific interventions are effective in reducing pesticide exposure and associated risks to human health and ecology. The overall goal of the African Pesticide Intervention Project (APsent) study is to better understand ongoing research and public health activities related to interventions in Africa through the implementation of suitable target-specific situations or use contexts. A systematic review of the scientific literature on pesticide intervention studies with a focus on Africa was conducted. This was followed by a qualitative survey among stakeholders involved in pesticide research or management in the African region to learn about barriers to and promoters of successful interventions. The project was concluded with an international workshop in November 2021, where a broad range of topics relevant to occupational and environmental health risks were discussed such as acute poisoning, street pesticides, switching to alternatives, or disposal of empty pesticide containers. Key areas of improvement identified were training on pesticide usage techniques, research on the effectiveness of interventions targeted at exposure reduction and/or behavioral changes, awareness raising, implementation of adequate policies, and enforcement of regulations and processes