Anuario Mariateguiano. Lima, Empresa Editora Amauta, Año VIII, Vol. 8, 1996, 325 p.

Fil: Beigel, Fernanda

Centros y periferias en la circulación internacional del conocimiento

América Latina formó parte del proceso de internacionalización de la ciencia y se consolidó como circuito de investigación social y enseñanza universitaria a comienzos de los años 60, cuando se modernizaba el sistema de educación superior, se creaban agencias públicas de fomento de la investigación científica y se extendían los centros regionales. Este circuito regional atravesó etapas de expansión, así como períodos de contracción de la autonomía académica, como resultado de la desinstitucionalización perpetrada en el Cono Sur por las dictaduras militares y de los violentos ajustes ejecutados durante los años noventa en los sistemas científico-universitarios de la región. En este trabajo se analizan las nuevas tensiones que surgieron en las últimas dos décadas a partir de la estructura desigual de un Sistema Académico Mundial (SAM) que se ha configurado sobre la base de la "universalización" de la bibliometría como herramienta de evaluación de la ciencia, la supremacía del inglés y la concentración del capital académico en determinados polos. Todo lo cual plantea importantes desafíos a un circuito que publica básicamente en español/portugués, y que viene haciendo enormes esfuerzos para consolidar sistemas regionales de publicaciones científicas de acceso abierto.Fil: Beigel, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Mendoza. Instituto de Ciencias Humanas, Sociales y Ambientales; Argentina

A teoria da dependência em seu laboratorio

A “dependência” tem sido, em distintas épocas, um tema central dentro do campo intelectual latino-americano. Apareceu com força durante a segunda metade do século XIX, no contexto da “Emancipação Mental” e da “Segunda Independência”. Continuou na década de 1920 com o debate cosmopolitismo/nacionalismo, e reapareceu em fins de 1950 com os movimentos de descolonização e libertação. Desenvolveu-se como assunto sociológico e como teoria da mudança social no campo acadêmico chileno, entre 1964 e 1973, sob o impulso de uma política consistente de consolidação do sistema científico e da educação superior. Quando foi eleito democraticamente o governo socialista de Salvador Allende, Santiago se constituiu como o eixo de um dinâmico circuito acadêmico regional. Neste trabalho, propomo-nos a analisar, a partir de uma perspectiva sócio-histórica, as condições de emergência da Escola Latino-Americana da Dependência (Blömstron & Hettne, 1991) e as particularidades do espaço social no qual se produziu este conhecimentoThe "Dependency" has been , at different times , a central theme within the Latin American intellectual field . Appeared strongly during the second half of the nineteenth century , in the context of " Mental Emancipation " and " Second Independence " Continued in the 1920s with cosmopolitanism / nationalism debate , and reappeared in late 1950 with the movements of decolonization and liberation. Developed as a sociological subject and as a theory of social change in the Chilean academic field between 1964 and 1973 , under the impulse of a consistent policy of consolidating and scientific system of higher education . In this year , when it was democratically elected socialist government of Salvador Allende , Santiago was constituted as the axis of a dynamic regional academic circuit. In this work , we propose to analyze, from a sociohistorical perspective , the conditions of emergence of the Latin American School of Dependency ( Blömstron & Hettne , 1991) and the particularities of the social space in which this knowledge is produced.Fil: Beigel, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Ciencias Humanas, Sociales y Ambientales; Argentin

Mariátegui, José Carlos. Mariátegui total. Edición Conmemorativa del Centenario de José Carlos Mariátegui, 2 Tomos, Lima, Empresa Editora Amauta,1994, 3905 p.

Fil: Beigel, Fernanda. Universidad Nacional de Cuy

Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease

Background/aim: Interleukin 31 (IL31), primarily expressed in activated lymphocytes, signals through a heterodimeric receptor complex consisting of the IL31 receptor alpha (IL31R\textgreeka) and the oncostatin M receptor (OSMR). The aim of this study was to analyse IL31 receptor expression, signal transduction, and specific biological functions of this cytokine system in intestinal inflammation.Methods: Expression studies were performed by RT-PCR, quantitative PCR, western blotting, and immunohistochemistry. Signal transduction was analysed by western blotting. Cell proliferation was measured by MTS assays, cell migration by restitution assays.Results: Colorectal cancer derived intestinal epithelial cell (IEC) lines express both IL31 receptor subunits, while their expression in unstimulated primary murine IEC was low. LPS and the proinflammatory cytokines TNF-\textgreeka, IL1\textgreekb, IFN-\textgreekg, and sodium butyrate stimulation increased IL31, IL31R\textgreeka, and OSMR mRNA expression, while IL31 itself enhanced IL8 expression in IEC. IL31 mediates ERK-1/2, Akt, STAT1, and STAT3 activation in IEC resulting in enhanced IEC migration. However, at low cell density, IL31 had significant antiproliferative capacities (p<0.005). IL31 mRNA expression was not increased in the TNF\textgreekDARE mouse model of ileitis but in inflamed colonic lesions compared to non-inflamed tissue in patients with Crohn's disease (CD; average 2.4-fold increase) and in patients with ulcerative colitis (UC; average 2.6-fold increase) and correlated with the IL-8 expression in these lesions (r = 0.564 for CD; r = 0.650 for UC; total number of biopsies analysed: n = 88).Conclusion: IEC express the functional IL31 receptor complex. IL31 modulates cell proliferation and migration suggesting a role in the regulation of intestinal barrier function particularly in intestinal inflammation