Randomised positive control trial of NSAID and antimicrobial treatment for calf fever caused by pneumonia

One hundred and fifty-four preweaning calves were followed between May and October 2015. Calves were fitted with continuous monitoring temperature probes (TempVerified FeverTag), programmed so a flashing light emitting diode (LED) light was triggered following six hours of a sustained ear canal temperature of ≥39.7°C. A total of 83 calves (61.9 per cent) developed undifferentiated fever, with a presumptive diagnosis of pneumonia through exclusion of other calf diseases. Once fever was detected, calves were randomly allocated to treatment groups. Calves in group 1 (NSAID) received 2 mg/kg flunixin meglumine (Allevinix, Merial) for three consecutive days and group 2 (antimicrobial) received 6 mg/kg gamithromycin (Zactran, Merial). If fever persisted for 72 hours after the initial treatment, calves were given further treatment (group 1 received antimicrobial and group 2 received NSAID). Calves in group 1 (NSAID) were five times more likely (P=0.002) to require a second treatment (the antimicrobial) after 72 hours to resolve the fever compared with the need to give group 2 (antimicrobial) calves a second treatment (NSAID). This demonstrates the importance of ongoing monitoring and follow-up of calves with respiratory disease. However, of calves with fever in group 1 (NSAID), 25.7 per cent showed resolution following NSAID-only treatment with no detrimental effect on the development of repeated fever or daily live weight gain. This suggests that NSAID alone may be a useful first-line treatment, provided adequate attention is given to ongoing monitoring to identify those cases that require additional antimicrobial treatment

Application of synchronous compensators in the GB transmission network to address protection challenges from increasing renewable generation

The GB transmission network is experiencing significant changes in its generation mix, with increasing volume of renewables and the decommissioning of large-scale thermal power plants. One of the main challenges resulting from these changes in the generation portfolio is the potential impact on the reliable operation of the existing protection schemes. Specifically, the likely decrease in the fault level may result in conventional protection schemes being slow/failing in detection faults, and the decrease of the system inertia would lead to a power system being more sensitive to disturbances, which may subsequently lead to undesired operation of Rate of Change of Frequency (RoCoF) – based Loss-of-Main (LOM) relays. Synchronous compensators are considered to have the potential to offer, among other benefits, a boost to system inertia and an increase of system fault level, which could facilitate the operation of protection systems in future energy scenarios. This paper presents the initial studies conducted under a project that has been initiated by a number of utility companies in the UK, focusing on the demonstration and deployment of the first synchronous compensator at a strategic point in the GB transmission system. The studies investigate the potential impacts of a GB transmission system with high penetration of non-synchronous generation on fault levels and system inertia, while contrasting the results with that of a system reinforced by synchronous compensation. The results of the inertia studies show that synchronous compensation could be used as a potential solution to limit system RoCoF following a disturbance, thereby reducing the risk of a cascading event as a result of the tripping of RoCoF relays. In the fault level studies, it was observed that while increasing the synchronous compensator rating, fault current and short circuit ratio increased, with a faster rate of increase the closer the synchronous compensator is to the fault. This observation suggests that synchronous compensators can also be used to minimise the risk of commutation failure of HVDC links, with the added likelihood of ensuring that the network protection operates correctly in low fault level scenarios

Extraction of Zero-Point Energy from the Vacuum: Assessment of Stochastic Electrodynamics-Based Approach as Compared to Other Methods

In research articles and patents several methods have been proposed for the extraction of zero-point energy from the vacuum. None of the proposals have been reliably demonstrated, yet they remain largely unchallenged. In this paper the underlying thermodynamics principles of equilibrium, detailed balance, and conservation laws are presented for zero-point energy extraction. The proposed methods are separated into three classes: nonlinear processing of the zero-point field, mechanical extraction using Casimir cavities, and the pumping of atoms through Casimir cavities. The first two approaches are shown to violate thermodynamics principles, and therefore appear not to be feasible, no matter how innovative their execution. The third approach, based upon stochastic electrodynamics, does not appear to violate these principles, but may face other obstacles. Initial experimental results are tantalizing but, given the lower than expected power output, inconclusive.Comment: 18 pages including 12 figure

The Performance Pay Premium and Wage Dispersion in Britain

Estimates of the performance pay (PP) premium using household survey data are upwardly biased due to the use of PP contracts in higher paying workplaces. Using nationally representative linked employer‐employee data we estimate the PP premium at the mean and across the wage distribution, after accounting for workplace heterogeneity. We then present the effects of PP on the wage distribution. Failure to account for the use of PP in high paying workplaces overstates the PP premium by one‐third. The premium rises as one moves up the wage distribution, but the effect is more modest after having accounted for workplace heterogeneity

Cambium non est mutuum: exchange and interest rates in medieval Europe

A major gap in our understanding of the medieval economy concerns interest rates, especially relating to commercial credit. Although direct evidence about interest rates is scattered and anecdotal, there is much more surviving information about exchange rates. Since both contemporaries and historians have suggested that exchange and rechange transactions could be used to disguise the charging of interest in order to circumvent the usury prohibition, it should be possible to back out the interest rates from exchange rates. The following analysis is based on a new dataset of medieval exchange rates collected from commercial correspondence in the archive of Francesco di Marco Datini of Prato, c.1383-1411. It demonstrates that the time value of money was consistently incorporated into market exchange rates. Moreover, these implicit interest rates are broadly comparable to those received from other types of commercial loan and investment. Although on average profitable, the return on any individual exchange and rechange transaction did involve a degree of uncertainty that may have justified their non-usurious nature. However, there were also practical reasons why medieval merchants may have used foreign exchange transactions as a means of extending credit

On the Link Between Central Black Holes, Bar Dynamics, and Dark Matter Halos in Spiral Galaxies

The discovery of a relationship between supermassive black hole (SMBH) mass and spiral arm pitch angle (P) is evidence that SMBHs are tied to the overall secular evolution of a galaxy. The discovery of SMBHs in late-type galaxies with little or no bulge suggests that an underlying correlation between the dark matter halo concentration and SMBH mass (MBH) exists, rather than between the bulge mass and MBH. In this paper we measure P using a two-dimensional fast fourier transform and estimate the bar pattern speeds of 40 barred spiral galaxies from the Carnegie-Irvine Galaxy Survey. The pattern speeds were derived by estimating the gravitational potentials of our galaxies from Ks-band images and using them to produce dynamical simulation models. The pattern speeds allow us to identify those galaxies with low central dark halo densities, or fast rotating bars, while P provides an estimate of MBH. We find that a wide range of MBH exists in galaxies with low central dark matter halo densities, which appears to support other theoretical results. We also find that galaxies with low central dark halo densities appear to follow more predictable trends in P versus de Vaucouleurs morphological type (T) and bar strength versus T than barred galaxies in general. The empirical relationship between MBH and total gravitational mass of a galaxy (Mtot) allows us to predict the minimum Mtot that will be observationally measured of our fast bar galaxies. These predictions will be investigated in a subsequent paper.Comment: 17 pages, 1 table, 11 figures, accepted for publication in MNRA

Feedback and the Structure of Simulated Galaxies at redshift z=2

We study the properties of simulated high-redshift galaxies using cosmological N-body/gasdynamical runs from the OverWhelmingly Large Simulations (OWLS) project. The runs contrast several feedback implementations of varying effectiveness: from no-feedback, to supernova-driven winds to powerful AGN-driven outflows. These different feedback models result in large variations in the abundance and structural properties of bright galaxies at z=2. We find that feedback affects the baryonic mass of a galaxy much more severely than its spin, which is on average roughly half that of its surrounding dark matter halo in our runs. Feedback induces strong correlations between angular momentum content and galaxy mass that leave their imprint on galaxy scaling relations and morphologies. Encouragingly, we find that galaxy disks are common in moderate-feedback runs, making up typically ~50% of all galaxies at the centers of haloes with virial mass exceeding 1e11 M_sun. The size, stellar masses, and circular speeds of simulated galaxies formed in such runs have properties that straddle those of large star-forming disks and of compact early-type galaxies at z=2. Once the detailed abundance and structural properties of these rare objects are well established it may be possible to use them to gauge the overall efficacy of feedback in the formation of high redshift galaxies.Comment: 16 pages, 12 figures. Accepted for publication in MNRAS. Minor changes to match published versio

Constructing futures: a social constructionist perspective on foresight methodology

The aim of this paper is to demonstrate the relationship between a particular epistemological perspective and foresight methodology. We draw on a body of social theory concerned with the way that meaning is produced and assimilated by society; specifically, the social construction of knowledge, which is distinguished from its nearneighbour constructivism by its focus on inter-subjectivity. We show that social constructionism, at least in its weak form, seems to be implicit in many epistemological assumptions underlying futures studies. We identify a range of distinctive methodological features in foresight studies, such as time, descriptions of difference, participation and values, and examine these from a social constructionist perspective. It appears that social constructionism is highly resonant with the way in which knowledge of the future is produced and used. A social constructionism perspective enables a methodological reflection on how, with what legitimacy, and to what social good, knowledge is produced. Foresight that produces symbols without inter-subjective meaning neither anticipates, nor produces futures. Our conclusion is that foresight is both a social construction, and a mechanism for social construction. Methodologically, foresight projects should acknowledge the socially constructed nature of their process and outcomes as this will lead to greater rigour and legitimacy

SCREENING FOR CLAUSTROPHOBIA IN MRI – A PILOT STUDY

Purpose- Claustrophobia during MRI examinations still presents a significant burden for patients and the NHS. Despite many strategies being suggested to reduce this burden, many are not routinely practiced due to questions over their cost-effectiveness. One way to ensure that strategies are cost effective is to screen for those patients who are most likely to experience difficulties during the examination.Method – This pilot study utilised the Claustrophobia Questionnaire (CLQ) to determine its predictive qualities in screening for claustrophobia in MRI. A retrospective sample of patients who withdrew from the MRI examination (citing claustrophobia as the cause) were cross matched against a population who were able to tolerate the exam.Results – The results were analysed using Mann Whitney and demonstrated a significant difference in the scores between those who could tolerate the MRI environment and those who could not.Conclusion – The CLQ may be a valid tool for screening those patients who may be unable to tolerate MRI examinations prior to attendance, enabling strategies to be targeted to this particular group

UK and US board director perceptions of the significance of gender and racial diversity on board governance

This mixed-methods study examines the perceptions and opinions of United Kingdom FTSE 350, and US Fortune 500 board of director members regarding the significance of gender and racial diversity on board governance. Perceptions were gathered from eighty-two directors using self-reported surveys and semi-structured interviews. This thesis provides: (1) an opportunity to investigate the perceptions (opinions) of directors regarding the effects of board gender and racial diversity on new board appointments and on the dynamics of board decision making (2) an opportunity to investigate the perception (opinions) of directors regarding the effects of social capital, new board appointments and the dynamics of board decision making, and (3) an opportunity to investigate comparatively the differences between UK and US director perceptions regarding the effects of board gender and racial diversity on new board appointments and board decision making. My findings indicate that directors believe that expertise and experience are by far the most important attributes when decisions on the selection of new directors are being considered. While US directors report observing tangible benefits to gender and racial diversity, for their firms, as well as a willingness to consider diversity as an attribute in the selection process; most UK directors were strongly opposed to positive discrimination measures.1 A majority of directors do not believe that their own demographic characteristics, such as race or gender were attributes to their being selected to a board position; however white males perceive that these attributes were considered attributes to the appointment of diverse directors. Moreover, in the United Kingdom, male directors reported that they may be at a disadvantage for board selection when compared to their female counterparts, hence advocating for a selection process with minimal considerations of the demographic characteristics of new directors. Directors do not seem to consider diverse social capital of directors when making board appointments. Instead, US directors were more likely to be assisted in board appointments by their having similar social capital, and UK directors indicated that they only consider director expertise, and that expertise is considered to ensure a broad mix of skills and professional experience on the board