Existence of subcritical percolation phases for generalised weight-dependent random connection models

We derive a sufficient condition for the existence of a subcritical percolation phase for a wide range of continuum percolation models where each vertex is embedded into Euclidean space and carries an independent weight. In contrast to many established models, the presence of an edge is not only allowed to depend on the distance and weights of its end vertices but can also depend on the surrounding vertex set. Our result can be applied in particular to models combining heavy-tailed degree distributions and long-range effects, which are typically well connected. Moreover, we establish bounds on the tail-distribution of the number of points and the diameter of the subcritical component of a typical point. The proofs rest on a multi-scale argument

Clinical characteristics of pediatric hospitalizations associated with 2009 pandemic influenza a (H1N1) in Northern Bavaria, Germany

Background: The 2009 pandemic influenza A (H1N1) (PIA) virus infected large parts of the pediatric population with a wide clinical spectrum and an initially unknown complication rate. The aims of our study were to define clinical characteristics and outcome of pandemic influenza A (H1N1) 2009-associated hospitalizations (PIAH) in children <18 years of age. All hospitalized cases of children <18 years of age with laboratory-confirmed pandemic influenza A (H1N1) 2009 in the region of Wuerzburg (Northern Bavaria, Germany) between July 2009 and March 2010 were identified. For these children a medical chart review was performed to determine their clinical characteristics and complications. Results: Between July 2009 and March 2010, 94 PIAH (62% males) occurred in children <18 years of age, with a median age of 7 years (IQR: 3–12 years). Underlying diseases and predisposing factors were documented in 40 (43%) children; obesity (n = 12, 30%), asthma (n = 10, 25%) and neurologic disorders (n = 8, 20%) were most frequently reported. Sixteen (17%) children received oxygen supplementation; three (3%) children required mechanical ventilation. Six (6%) children were admitted to an intensive care unit, four of them with underlying chronic diseases. Conclusions: Most PIAH demonstrated a benign course of disease. However, six children (6%) needed treatment at an intensive care unit for severe complications

Facioscapulohumeral muscular dystrophy and Charcot-Marie-Tooth neuropathy 1A-evidence for "double trouble" overlapping syndromes

Background: We report on a patient with genetically confirmed overlapping diagnoses of CMT1A and FSHD. This case adds to the increasing number of unique patients presenting with atypical phenotypes, particularly in FSHD. Even if a mutation in one disease gene has been found, further genetic testing might be warranted in cases with unusual clinical presentation. Case presentation: The reported 53 years old male patient suffered from walking difficulties and foot deformities first noticed at age 20. Later on, he developed scapuloperoneal and truncal muscle weakness, along with atrophy of the intrinsic hand and foot muscles, pes cavus, claw toes and a distal symmetric hypoesthesia. Motor nerve conduction velocities were reduced to 20 m/s in the upper extremities, and not educible in the lower extremities, sensory nerve conduction velocities were not attainable. Electromyography showed both, myopathic and neurogenic changes. A muscle biopsy taken from the tibialis anterior muscle showed a mild myopathy with some neurogenic findings and hypertrophic type 1 fibers. Whole-body muscle MRI revealed severe changes in the lower leg muscles, tibialis anterior and gastrocnemius muscles were highly replaced by fatty tissue. Additionally, fatty degeneration of shoulder girdle and straight back muscles, and atrophy of dorsal upper leg muscles were seen. Taken together, the presenting features suggested both, a neuropathy and a myopathy. Patient's family history suggested an autosomal dominant inheritance. Molecular testing revealed both, a hereditary motor and sensory neuropathy type 1A (HMSN1A, also called Charcot-Marie-Tooth neuropathy 1A, CMT1A) due to a PMP22 gene duplication and facioscapulohumeral muscular dystrophy (FSHD) due to a partial deletion of the D4Z4 locus (19 kb). Conclusion: Molecular testing in hereditary neuromuscular disorders has led to the identification of an increasing number of atypical phenotypes. Nevertheless, finding the right diagnosis is crucial for the patient in order to obtain adequate medical care and appropriate genetic counseling, especially in the background of arising curative therapies

Sound Objects, Cybernetics and Interactivity: tracing aesthetic connections between three of my recent electroacoustic compositions

Bachelorarbeit Computermusi

Die Wertigkeit der systematischen Biopsie bei der transperinealen MRT-/TRUS-fusionierten Prostatabiopsie

Einleitung: Die leitliniengerechte Prostatabiopsie (Bx) beruht auf der Kombination systematischer (sysBx) und gezielter (targBx) Biopsien und erfolgt MRT-fusioniert. Oftmals überlappen die Positionen der sysBx mit den MRT-Zielläsionen. Diese Studie untersucht die Wertigkeit der sysBx unter Berücksichtigung des "Overlap" (OL). Methode: Es erfolgte die statistische Analyse prospektiver Patientendaten nach transperinealer MRT-/TRUS-fusionierter PBx. Die Detektionsraten der sysBx wurden vor und nach Berücksichtigung des OL analysiert. Ergebnis: Die PCa-Detektionsrate der sysBx vor und nach Berücksichtigung des OL betrug 56,7 % und 51,6 % (p = 0,008, ISUP $\geq$ 1) und 43,9 % und 40,1 % (p = 0,031, ISUP $\geq$ 2). Diskussion: Die systematische Bx sollte weiterhin durchgeführt werden. Die Wertigkeit der systematischen Bx wird jedoch durch das OL überschätzt