2,444 research outputs found
Surge motion of an ice floe in waves: comparison of theoretical and experimental models
A theoretical model and an experimental model of surge motions of an ice floe
due to regular waves are presented. The theoretical model is a modified version
of Morrison's equation, valid for small floating bodies. The experimental model
is implemented in a wave basin at scale 1:100, using a thin plastic disk to
model the floe. The processed experimental data displays a regime change in
surge amplitude when the incident wavelength is approximately twice the floe
diameter. It is shown that the theoretical model is accurate in the large
wavelength regime, but highly inaccurate for the small wavelength regime.Comment: 11 pages, 10 figure
Transcription factor EB activation rescues advanced αB-crystallin mutation-induced cardiomyopathy by normalizing desmin localization
Comparative ergonomic workflow and user experience analysis of MRI versus fluoroscopy-guided vascular interventions:an iliac angioplasty exemplar case study
Purpose A methodological framework is introduced to assess and compare a conventional fluoroscopy protocol for peripheral angioplasty with a new magnetic resonant imaging (MRI)-guided protocol. Different scenarios were considered during interventions on a perfused arterial phantom with regard to time-based and cognitive task analysis, user experience and ergonomics. Methods Three clinicians with different expertise performed a total of 43 simulated common iliac angioplasties (9 fluoroscopic, 34 MRI-guided) in two blocks of sessions. Six different configurations for MRI guidance were tested in the first block. Four of them were evaluated in the second block and compared to the fluoroscopy protocol. Relevant stages’ durations were collected, and interventions were audio-visually recorded from different perspectives. A cued retrospective protocol analysis (CRPA) was undertaken, including personal interviews. In addition, ergonomic constraints in the MRI suite were evaluated. Results Significant differences were found when comparing the performance between MRI configurations versus fluoroscopy. Two configurations [with times of 8.56 (0.64) and 9.48 (1.13) min] led to reduce procedure time for MRI guidance, comparable to fluoroscopy [8.49 (0.75) min]. The CRPA pointed out the main influential factors for clinical procedure performance. The ergonomic analysis quantified musculoskeletal risks for interventional radiologists when utilising MRI. Several alternatives were suggested to prevent potential low-back injuries. Conclusions This work presents a step towards the implementation of efficient operational protocols for MRI-guided procedures based on an integral and multidisciplinary framework, applicable to the assessment of current vascular protocols. The use of first-user perspective raises the possibility of establishing new forms of clinical training and education
Regression modeling of longitudinal binary outcomes with outcome-dependent observation times
Conventional longitudinal data analysis methods assume that outcomes are independent of the data-collection schedule. However, the independence assumption may be violated, for example, when adverse events trigger additional physician visits in between prescheduled follow-ups. Observation times may therefore be associated with outcome values, which may introduce bias when estimating the eect of covariates on outcomes using standard longitudinal regression methods. Existing semi-parametric methods that accommodate outcome-dependent observation times are limited to the analysis of continuous outcomes. We develop new methods for the analysis of binary outcomes, while retaining the exibility of semi-parametric models. Our methods are based on counting process approaches, rather than relying on possibly intractable likelihood-based or pseudo-likelihood-based approaches, and provide marginal, population-level inference. In simulations, we evaluate the statistical properties of our proposed methods. Comparisons are made to \u27naive\u27 GEE approaches that either do not account for outcome-dependent observation times or incorporate weights based on the observation-time process. We illustrate the utility of our proposed methods using data from a randomized controlled trial of interventions designed to improve adherence to warfarin therapy. We show that our method performs well in the presence of outcome-dependent observation times, and provide identical inference to \u27naive\u27 approaches when observation times are not associated with outcomes
On There Being Infinitely Many Thinkable Thoughts: A Reply to Porpora and a Defence of Tegmark
Flat-H Redundant Frangible Joint Design Evolution 2018: Feasibility Study Conclusions
This paper reports results of an investigation into developing a single failure tolerant pyrotechnic linear separation system which features completely redundant explosive trains suitable for human spaceflight. It is a follow up to Flat-H Redundant Frangible Joint Design Evolution 2017 and Flat-H Redundant Frangible Joint Evolution. The paper chronicles the history of the redundant frangible joint development program including testing, analysis, and design improvements from 2014 to the present culminating in a successful proof-of-concept prototype. The paper describes work done to address debris control and containment of combustion products. A performance optimization strategy is presented along with optimization results. Additionally a novel containment manifold design is presented with test results
Discovery and Early Evolution of ASASSN-19bt, the First TDE Detected by TESS
We present the discovery and early evolution of ASASSN-19bt, a tidal
disruption event (TDE) discovered by the All-Sky Automated Survey for
Supernovae (ASAS-SN) at a distance of Mpc and the first TDE to be
detected by TESS. As the TDE is located in the TESS Continuous Viewing Zone,
our dataset includes 30-minute cadence observations starting on 2018 July 25,
and we precisely measure that the TDE begins to brighten days before
its discovery. Our dataset also includes 18 epochs of Swift UVOT and XRT
observations, 2 epochs of XMM-Newton observations, 13 spectroscopic
observations, and ground data from the Las Cumbres Observatory telescope
network, spanning from 32 days before peak through 37 days after peak.
ASASSN-19bt thus has the most detailed pre-peak dataset for any TDE. The TESS
light curve indicates that the transient began to brighten on 2019 January 21.6
and that for the first 15 days its rise was consistent with a flux power-law model. The optical/UV emission is well-fit by a blackbody SED,
and ASASSN-19bt exhibits an early spike in its luminosity and temperature
roughly 32 rest-frame days before peak and spanning up to 14 days that has not
been seen in other TDEs, possibly because UV observations were not triggered
early enough to detect it. It peaked on 2019 March 04.9 at a luminosity of
ergs s and radiated
ergs during the 41-day rise to peak. X-ray observations after peak indicate a
softening of the hard X-ray emission prior to peak, reminiscent of the
hard/soft states in X-ray binaries.Comment: 23 pages, 14 figures, 5 tables. A machine-readable table containing
the host-subtracted photometry presented in this manuscript is included as an
ancillary fil
Reconsidering power and distance
A wide range of studies indicate that power and distance affect the production and interpretation of language. However, this paper argues that greater consideration needs to be given to the conceptual nature of these dimensions, and to terminological usage. In the first half of the paper, the need for this consideration is explained. A number of pragmatic studies are examined, and this reveals that authors often use the same terms with different meanings, or different terms with the same meaning, and that the parameters are rarely explicitly defined. Then the paper reviews recent calls for an extra parameter of interlocutor relations to be added: for affect to be separated from distance. In the second half of the paper, relevant social psychological research is reported, and it is concluded that the number of ‘horizontal’ dimensions of interlocutor relations needs to be reconsidered. Power, on the other hand, emerges as a robust and relatively unitary dimension, yet its label has connotations that may not be cross-culturally valid
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