The chemical abundances in the Galactic Centre from the atmospheres of Red Supergiants

The Galactic Centre (GC) has experienced a high degree of recent star-forming activity, as evidenced by the large number of massive stars currently residing there. The relative abundances of chemical elements in the GC may provide insights into the origins of this activity. Here, we present high-resolution $H$-band spectra of two Red Supergiants in the GC (IRS~7 and VR~5-7), and in combination with spectral synthesis we derive abundances for Fe and C, as well as other $\alpha$-elements Ca, Si, Mg Ti and O. We find that the C-depletion in VR~5-7 is consistent with the predictions of evolutionary models of RSGs, while the heavy depletion of C and O in IRS~7's atmosphere is indicative of deep mixing, possibly due to fast initial rotation and/or enhanced mass-loss. Our results indicate that the {\it current} surface Fe/H content of each star is slightly above Solar. However, comparisons to evolutionary models indicate that the {\it initial} Fe/H ratio was likely closer to Solar, and has been driven higher by H-depletion at the stars' surface. Overall, we find $\alpha$/Fe ratios for both stars which are consistent with the thin Galactic disk. These results are consistent with other chemical studies of the GC, given the precision to which abundances can currently be determined. We argue that the GC abundances are consistent with a scenario in which the recent star-forming activity in the GC was fuelled by either material travelling down the Bar from the inner disk, or from the winds of stars in the inner Bulge -- with no need to invoke top-heavy stellar Initial Mass Functions to explain anomalous abundance ratios.Comment: 23 pages, 5 figs. Accepted for publication in Ap

Near-Infrared Variability Study of the Central 2.3 arcmin x 2.3 arcmin of the Galactic Centre II. Identification of RR Lyrae Stars in the Milky Way Nuclear Star Cluster

Because of strong and spatially highly variable interstellar extinction and extreme source crowding, the faint (K>15) stellar population in the Milky Way's nuclear cluster is still poorly studied. RR Lyrae stars provide us with a tool to estimate the mass of the oldest, relative dim stellar population. Recently, we analyzed HST/WFC3/IR observations of the central 2.3'x2.3' of the Milky Way and found 21 variable stars with periods between 0.2 and 1d. Here, we present a further comprehensive analysis of these stars. The period-luminosity relationship of RR Lyrae is used to derive their extinctions and distances. Using multiple approaches, we classify our sample as four RRc, four RRab and three candidates, ten binaries. Especially, the four RRabs show sawtooth light curves and fall exactly onto the Oosterhoff I division in the Bailey diagram. Compared to the RRabs reported by Minniti et al, 2016, our new RRabs have higher extinction (A_K>1.8) and should be closer to the Galactic Centre. The extinction and distance of one RRab match those for the nuclear star cluster given in previous works. We perform simulations and find that after correcting for incompleteness, there could be no more than 40 RRabs within the nuclear star cluster and in our field-of-view. Through comparing with the known globular clusters of the Milky Way, we estimate that if there exists an old, metal-poor (-1.5<[Fe/H]<-1) stellar population in the Milky Way nuclear star cluster on a scale of 5x5pc, then it contributes at most 4.7x10^5 solar mass, i.e., ~18% of the stellar mass.Comment: 33 pages, 10 figures. The paper has been accepted to be published in MNRA

3-Dimensional Kinematics in low foreground extinction windows of the Galactic Bulge: Radial Velocities for 6 bulge fields

The detailed structure of the Galactic bulge still remain uncertain. The strong difficulties of obtaining observations of stars in the Galactic bulge have hindered the acquisition of a kinematic representation for the inner kpc of the Milky Way. The observation of the 3-d kinematics in several low foreground extinction windows can solve this problem. We have developed a new technique, which combines precise stellar HST positions and proper motions with integral field spectroscopy, in order to obtain reliable 3-d stellar kinematics in crowded fields of the Galactic center. In addition, we present results using the new techniques for six fields in our project. A significant vertex deviation has been found in some of the fields in agreement with previous determinations. This result confirms the presence of a stellar bar in the Galactic bulge.Comment: 14 pages, 15 figures, Accepted for publication in A&

The Effect of Hook Scarring on Angler Satisfaction on the West Fork of the Bitterroot River

Anglers in Montana are shifting towards a catch and release ethic. This shift is causing increased hook scarring in fish populations. Despite these increasing trends few studies have quantified the rate of hook scarring anglers observe, and their attitudes about hook scarring. We developed and conducted an angler survey on the West Fork of the Bitterroot, a section of river with over 30% scarring rates in Westslope Cutthroat in a 2014 Montana Fish, Wildlife and Parks (MFWP) electrofishing survey. We surveyed floating anglers as they pulled out at the end of the fishing day to get complete catch data, satisfaction information, observed hook scarring rates, attitudes about hook scarring, and equipment used. We surveyed 47 anglers of which 94% were fly-fishing and 72% were using barbless hooks. Anglers observed lower hook scarring rates than the previous MFWP electrofishing survey. On average anglers reported hook scarring rates to be very acceptable. There was no correlation between the rate of hook scarring anglers observed and satisfaction with their catch. As densities of anglers increase, more research is needed to understand the effects of angler gear type on hook scarring rates and the effect of hook scarring on angler satisfaction

Risk of acute myocardial infarction with NSAIDs in real world use : bayesian meta-analysis of individual patient data

OBJECTIVE To characterise the determinants, time course, and risks of acute myocardial infarction associated with use of oral non-steroidal anti-inflammatory drugs (NSAIDs). DESIGN Systematic review followed by a one stage bayesian individual patient data meta-analysis. DATA SOURCES Studies from Canadian and European healthcare databases. REVIEW METHODS Eligible studies were sourced from computerised drug prescription or medical databases, conducted in the general or an elderly population, documented acute myocardial infarction as specific outcome, studied selective cyclo-oxygenase-2 inhibitors (including rofecoxib) and traditional NSAIDs, compared risk of acute myocardial infarction in NSAID users with non-users, allowed for time dependent analyses, and minimised effects of confounding and misclassification bias. EXPOSURE AND OUTCOMES Drug exposure was modelled as an indicator variable incorporating the specific NSAID, its recency, duration of use, and dose. The outcome measures were the summary adjusted odds ratios of first acute myocardial infarction after study entry for each category of NSAID use at index date (date of acute myocardial infarction for cases, matched date for controls) versus non-use in the preceding year and the posterior probability of acute myocardial infarction. RESULTS A cohort of 446 763 individuals including 61 460 with acute myocardial infarction was acquired. Taking any dose of NSAIDs for one week, one month, or more than a month was associated with an increased risk of myocardial infarction. With use for one to seven days the probability of increased myocardial infarction risk (posterior probability of odds ratio >1.0) was 92% for celecoxib, 97% for ibuprofen, and 99% for diclofenac, naproxen, and rofecoxib. The corresponding odds ratios (95% credible intervals) were 1.24 (0.91 to 1.82) for celecoxib, 1.48 (1.00 to 2.26) for ibuprofen, 1.50 (1.06 to 2.04) for diclofenac, 1.53 (1.07 to 2.33) for naproxen, and 1.58 (1.07 to 2.17) for rofecoxib. Greater risk of myocardial infarction was documented for higher dose of NSAIDs. With use for longer than one month, risks did not appear to exceed those associated with shorter durations. CONCLUSIONS All NSAIDs, including naproxen, were found to be associated with an increased risk of acute myocardial infarction. Risk of myocardial infarction with celecoxib was comparable to that of traditional NSAIDS and was lower than for rofecoxib. Risk was greatest during the first month of NSAID use and with higher doses.Peer reviewe

Semantic Lexicon Acquisition for Learning Natural Language Interfaces

viii List of Tables xii List of Figures xiii Chapter 1 Introduction 1 Chapter 2 Background 6 2.1 Chill . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2.2 The Work of Jeff Siskind . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Chapter 3 Lexicon Learning and Wolfie 11 3.1 Problem Definition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 3.2 Potential Approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 3.3 The Wolfie Algorithm and an Example . . . . . . . . . . . . . . . . . . . . . . . . . 18 3.4 Generating Candidate Lexicon Items . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 3.5 Finding the Best Pair . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 3.6 Constraining Remaining Candidates . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Chapter 4 Wolfie Experimental Results: Learning for Database-Query Parsing 30 4..

Ultraviolet through Infrared Spectral Energy Distributions from 1000 SDSS Galaxies: Dust Attenuation

The meaningful comparison of models of galaxy evolution to observations is critically dependent on the accurate treatment of dust attenuation. To investigate dust absorption and emission in galaxies we have assembled a sample of ~1000 galaxies with ultraviolet (UV) through infrared (IR) photometry from GALEX, SDSS, and Spitzer and optical spectroscopy from SDSS. The ratio of IR to UV emission (IRX) is used to constrain the dust attenuation in galaxies. We use the 4000A break as a robust and useful, although coarse, indicator of star formation history (SFH). We examine the relationship between IRX and the UV spectral slope (a common attenuation indicator at high-redshift) and find little dependence of the scatter on 4000A break strength. We construct average UV through far-IR spectral energy distributions (SEDs) for different ranges of IRX, 4000A break strength, and stellar mass (M_*) to show the variation of the entire SED with these parameters. When binned simultaneously by IRX, 4000A break strength, and M_* these SEDs allow us to determine a low resolution average attenuation curve for different ranges of M_*. The attenuation curves thus derived are consistent with a lambda^{-0.7} attenuation law, and we find no significant variations with M_*. Finally, we show the relationship between IRX and the global stellar mass surface density and gas-phase-metallicity. Among star forming galaxies we find a strong correlation between IRX and stellar mass surface density, even at constant metallicity, a result that is closely linked to the well-known correlation between IRX and star-formation rate.Comment: 12 pages, 8 figures, 2 tables, appearing in the Dec 2007 GALEX special issue of ApJ Supp (29 papers

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.

Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth &gt;29X and analyze genotypes with four quantitative traits-plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and triglycerides. Common variant association yields known loci except for few variants previously poorly imputed. Rare coding variant association yields known Mendelian dyslipidemia genes but rare non-coding variant association detects no signals. A high 2M-SNP LDL-C polygenic score (top 5th percentile) confers similar effect size to a monogenic mutation (~30 mg/dl higher for each); however, among those with severe hypercholesterolemia, 23% have a high polygenic score and only 2% carry a monogenic mutation. At these sample sizes and for these phenotypes, the incremental value of WGS for discovery is limited but WGS permits simultaneous assessment of monogenic and polygenic models to severe hypercholesterolemia