The thermodynamic landscape of carbon redox biochemistry

Redox biochemistry plays a key role in the transduction of chemical energy in all living systems. Observed redox reactions in metabolic networks represent only a minuscule fraction of the space of all possible redox reactions. Here we ask what distinguishes observed, natural redox biochemistry from the space of all possible redox reactions between natural and non-natural compounds. We generate the set of all possible biochemical redox reactions involving linear chain molecules with a fixed numbers of carbon atoms. Using cheminformatics and quantum chemistry tools we analyze the physicochemical and thermodynamic properties of natural and non-natural compounds and reactions. We find that among all compounds, aldose sugars are the ones with the highest possible number of connections (reductions and oxidations) to other molecules. Natural metabolites are significantly enriched in carboxylic acid functional groups and depleted in carbonyls, and have significantly higher solubilities than non-natural compounds. Upon constructing a thermodynamic landscape for the full set of reactions as a function of pH and of steady-state redox cofactor potential, we find that, over this whole range of conditions, natural metabolites have significantly lower energies than the non-natural compounds. For the set of 4-carbon compounds, we generate a Pourbaix phase diagram to determine which metabolites are local energetic minima in the landscape as a function of pH and redox potential. Our results suggest that, across a set of conditions, succinate and butyrate are local minima and would thus tend to accumulate at equilibrium. Our work suggests that metabolic compounds could have been selected for thermodynamic stability, and yields insight into thermodynamic and design principles governing nature’s metabolic redox reactions.https://www.biorxiv.org/content/10.1101/245811v1Othe

Encoding the infrared excess (IRX) in the NUVrK color diagram for star-forming galaxies

We present an empirical method of assessing the star formation rate (SFR) of star-forming galaxies based on their locations in the rest-frame color-color diagram (NUV-r) vs (r-K). By using the Spitzer 24 micron sample in the COSMOS field (~16400 galaxies with 0.2 < z < 1.3) and a local GALEX-SDSS-SWIRE sample (~700 galaxies with z = < L_IR / L_UV > can be described by a single vector, NRK, that combines the two colors. The calibration between and NRK allows us to recover the IR luminosity, L_IR, with an accuracy of ~0.21 dex for the COSMOS sample and ~0.27 dex for the local one. The SFRs derived with this method agree with the ones based on the observed (UV+IR) luminosities and on the spectral energy distribution fitting for the vast majority (~85 %) of the star-forming population. Thanks to a library of model galaxy SEDs with realistic prescriptions for the star formation history, we show that we need to include a two-component dust model (i.e., birth clouds and diffuse ISM) and a full distribution of galaxy inclinations in order to reproduce the behavior of the stripes in the NUVrK diagram. In conclusion, the NRK method, based only on rest-frame UV and optical colors available in most of the extragalactic fields, offers a simple alternative of assessing the SFR of star-forming galaxies in the absence of far-IR or spectral diagnostic observations.Comment: 21 pages, 22 figures, in publication in Astronomy & Astrophysic

IRMA via SDN: Intrusion Response and Monitoring Appliance via Software-Defined Networking

Recent approaches to network intrusion prevention systems (NIPSs) use software-defined networking (SDN) to take advantage of dynamic network reconfigurability and programmability, but issues remain with system component modularity, network size scalability, and response latency. We present IRMA, a novel SDN-based NIPS for enterprise networks, as a network appliance that captures data traffic, checks for intrusions, issues alerts, and responds to alerts by automatically reconfiguring network flows via the SDN control plane. With a composable, modular, and parallelizable service design, we show improved throughput and less than 100 ms average latency between alert detection and response.Roy J. Carver FellowshipOpe

The role of exercise in atrial fibrillation prevention and promotion: Finding optimal ranges for health

The cardiovascular benefits of regular exercise have been well described, including a significant reduction in cardiovascular morbidity and mortality for those meeting recommended guidelines. Yet the impact of physical activity on the incidence of atrial fibrillation (AF) has been less clear. This review seeks to define the optimal dose and duration for the prevention and treatment of AF. In doing so, we review the evidence that supports a decline in AF risk for those who achieve a weekly physical activity dose slightly above the current recommended guidelines. Furthermore, we identify the reduced AF incidence in those individuals who attain a cardiorespiratory fitness of 8 METs (metabolic equivalents of task) or more during maximal exercise testing. Finally, we review the evidence that shows an excess of AF among regular participants of endurance exercise

Multidimensional: User with File Content and Server’s status based Authentication for Secure File Operations in Cloud

The popularity of data storage in cloud servers is getting more and more favoured in recent times. Its ease of storage, availability and synchronization of personalized cloud file storage using client applications made cloud storage more popular than ever. In cloud storage system, using a basic authentication method like username and password are still one of the most popular forms of authentication. However, the security ensure by such traditional authentication method is weak and vulnerable because the user name and password can be compromised by intruders or the user account can be left open by forgetting to logoff in public computers, leading to exposure of information to unauthorised users and hackers. In recent years, using a two-factor authentication has become a trend throughout network-based cloud services, online banking system and any form of services that requires user authentication. Here, in this paper a second layer authentication in the form of session key is used to ensure the authenticity of the activities of the user after user’s web-based account is logged-in successfully. The interesting and the critical contribution in this paper is the way the session key is generated and delivers to the authentic user. The key is generated by using the hash value of the file content, file size, file last modified, pseudo-random generated by the server using CPU temperature, clock speed, system time, and network packet timings, and user based 8 digit random position selection from a 32 digit Hex to mitigate against the attacker while performing vital file activities which may lead to data lost or data destruction or when user’s credentials are compromised

Response of Macroarthropod Assemblages to the Loss of Hemlock (Tsuga canadensis), a Foundation Species

In eastern North American forests, eastern hemlock (Tsuga canadensis) is a foundation species. As hemlock is lost from forests due to the invasive hemlock woolly adelgid (Adelges tsugae) and pre-emptive salvage logging, the structure of assemblages of species associated with hemlock is expected to change. We manipulated hemlock canopy structure at hectare scales to investigate the effects of hemlock death on assemblages of ants, beetles, and spiders in a New England forest. Relative to reference hemlock stands, both in situ death of hemlock and logging and removal of hemlock altered composition and diversity of beetles and spiders, and logging increased the species richness and evenness of ant assemblages. Species composition of ant assemblages in disturbed habitats was non-random relative to the regional species pool, but we found no evidence that interspecific competition shaped the structure of ant, beetle, or spider assemblages, in either manipulated or intact forest stands. Environmental filtering by hemlock appears to maintain low levels of species richness and evenness in forest stands, suggesting that the loss of hemlock due to the hemlock woolly adelgid or human activities will not likely lead to extirpations of ant, beetle, or spider species at local scales.Organismic and Evolutionary BiologyOther Research Uni