1082 Free-breathing single-shot DENSE myocardial strain imaging using deformable registration

Free-breathing scans are often desirable in patients who find breath-holding difficult. We present a new approach for free-breathing myocardial strain imaging with displacement-encoding (DENSE) [1]. It acquires images with a single-shot sequence and removes respiratory motion using deformable registration

Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway

Melanocortin-1 receptor (MC1R) and its ligands, a-melanocyte stimulating hormone (aMSH) and agouti signaling protein (ASIP), regulate switching between eumelanin and pheomelanin synthesis in melanocytes. Here we investigated biological effects and signaling pathways of ASIP. Melan-a non agouti (a ⁄ a) mouse melanocytes produce mainly eumelanin, but ASIP combined with phenylthiourea and extra cysteine could induce over 200-fold increases in the pheomelanin to eumelanin ratio, and a tan-yellow color in pelletted cells.Moreover, ASIP-treated cells showed reduced proliferation and a melanoblast-like appearance, seen also in melanocyte lines from yellow (Ay ⁄ a and Mc1re ⁄ Mc1re) mice. However ASIP-YY, a C-terminal fragment of ASIP, induced neither biological nor pigmentary changes. As, like ASIP, ASIP-YY inhibited the cAMP rise induced by aMSH analog NDP-MSH, and reduced cAMP level without added MSH, the morphological changes and depigmentation seemed independent of cAMP signaling. Melanocytes genetically null for ASIP mediators attractin or mahogunin (Atrnmg-3J ⁄ mg-3J or Mgrn1md-nc ⁄ md-nc) also responded to both ASIP and ASIP-YY in cAMP level, while only ASIP altered their proliferation and (in part) shape. Thus, ASIP–MC1R signaling includes a cAMP-independent pathway through attractin and mahogunin, while the known cAMP-dependent component requires neither attractin nor mahogunin.Parts of the research were supported by Wellcome Trust program grants 064583 and 078327 to D.C.B. and E.V.S.; the Japan Society for the Promotion of Science KAKENHI (grants 20790808 to T.H. and 18591262 and 20591357 to K.W. and S.I.); a Grant-in-Aid from the Japanese Ministry of Health, Labour and Welfare (K.J.), the Spanish Ministry of Education and Science BFU2006-12185 (L.M.), the South West Academic Network (A.J.D. and E.V.S.), and NIH grant DK064265 (B.Y. and G.L.M.).Peer reviewe

Use of Desulfovibrio and Escherichia coli Pd-nanocatalysts in reduction of Cr(VI) and hydrogenolytic dehalogenation of polychlorinated biphenyls and used transformer oil

BACKGROUND Desulfovibrio spp. biofabricate metallic nanoparticles (e.g. ‘Bio-Pd’) which catalyse the reduction of Cr(VI) to Cr(III) and dehalogenate polychlorinated biphenyls (PCBs). Desulfovibrio spp. are anaerobic and produce H2S, a potent catalyst poison, whereas Escherichia coli can be pre-grown aerobically to high density, has well defined molecular tools, and also makes catalytically-active ‘Bio-Pd’. The first aim was to compare ‘Bio-Pd’ catalysts made by Desulfovibrio spp. and E. coli using suspended and immobilised catalysts. The second aim was to evaluate the potential for Bio-Pd-mediated dehalogenation of PCBs in used transformer oils, which preclude recovery and re-use.\ud RESULTS Catalysis via Bio-PdD. desulfuricans and Bio-PdE. coli was compared at a mass loading of Pd:biomass of 1:3 via reduction of Cr(VI) in aqueous solution (immobilised catalyst) and hydrogenolytic release of Cl- from PCBs and used transformer oil (catalyst suspensions). In both cases Bio-PdD. desulfuricans outperformed Bio-Pd E. coli by ~3.5-fold, attributable to a ~3.5-fold difference in their Pd-nanoparticle surface areas determined by magnetic measurements (Bio-PdD. desulfuricans) and by chemisorption analysis (Bio-PdE. coli). Small Pd particles were confirmed on D. desulfuricans and fewer, larger ones on E. coli via electron microscopy. Bio-PdD. desulfuricans-mediated chloride release from used transformer oil (5.6 $\pm$ 0.8 $\mu$g mL-1 ) was comparable to that observed using several PCB reference materials. \ud CONCLUSIONS At a loading of 1:3 Pd: biomass Bio-PdD. desulfuricans is 3.5-fold more active than Bio-PdE. coli, attributable to the relative catalyst surface areas reflected in the smaller nanoparticle sizes of the former. This study also shows the potential of Bio-PdD. desulfuricans to remediate used transformer oil

Displaying desire and distinction in housing

The article discusses the significance of cultural capital for the understanding of the field of housing in contemporary Britain. It explores the relationship between housing and the position of individuals in social space mapped out by means of a multiple correspondence analysis. It considers the material aspects of housing and the changing contexts that are linked to the creation and display of desire for social position and distinction expressed in talk about home decoration as personal expression and individuals' ideas of a `dream house'. It is based on an empirical investigation of taste and lifestyle using nationally representative survey data and qualitative interviews. The article shows both that personal resources and the imagination of home are linked to levels of cultural capital, and that rich methods of investigation are required to grasp the significance of these normally invisible assets to broaden the academic understanding of the field of housing in contemporary culture

Magnetic moment of an electron near a surface with dispersion

Boundary-dependent radiative corrections that modify the magnetic moment of an electron near a dielectric or conducting surface are investigated. Normal-mode quantization of the electromagnetic field and perturbation theory applied to the Dirac equation for a charged particle in a weak magnetic field yield a general formula for the magnetic moment correction in terms of any choice of electromagnetic mode functions. For two particular models, a non-dispersive dielectric and an undamped plasma, it is shown that, by using contour integration techniques over a complex wave vector, this can be simplified to a formula featuring just integrals over TE and TM reflection coefficients of the surface. Analysing the magnetic moment correction for several models of surfaces, we obtain markedly different results from the previously considered simplistic 'perfect reflector' model, which is due to the inclusion of physically important features of the surface like evanescent field modes and dispersion in the material. Remarkably, for a general dispersive dielectric surface, the magnetic moment correction of an electron nearby has a peak whose position and height can be tuned by choice of material parameters

Finite-key security against coherent attacks in quantum key distribution

The work by Christandl, K\"onig and Renner [Phys. Rev. Lett. 102, 020504 (2009)] provides in particular the possibility of studying unconditional security in the finite-key regime for all discrete-variable protocols. We spell out this bound from their general formalism. Then we apply it to the study of a recently proposed protocol [Laing et al., Phys. Rev. A 82, 012304 (2010)]. This protocol is meaningful when the alignment of Alice's and Bob's reference frames is not monitored and may vary with time. In this scenario, the notion of asymptotic key rate has hardly any operational meaning, because if one waits too long time, the average correlations are smeared out and no security can be inferred. Therefore, finite-key analysis is necessary to find the maximal achievable secret key rate and the corresponding optimal number of signals.Comment: 9 pages, 4 figure

Generation of entangled squeezed states in atomic Bose-Einstein condensates

A method for producing entangled squeezed states (ESSs) for atomic Bose-Einstein condensates (BECs) is proposed by using a BEC with three internal states and two classical laser beams. We show that it is possible to generate two-state and multi-state ESSs under certain circumstances.Comment: 6 pages, 1 figur

Atomic parity violation in cesium and implications for the 3 - 3 - 1 models

The parity violation in cesium atom is analysed in the framework of the models based on the SU(3)_C X SU(3)_L X U(1)_N gauge group. It is shown that in the minimal version, the main contribution to a deviation of weak charge \Delta Q_W due to direct Z' exchange is negative. New data on parity violation in the cesium atom seems not favour to the minimal version, while it gets a positive value in the version with right-handed neutrinos. We obtain a bound on the $Z'$ mass at a range from 1.4 TeV to 2.6 TeV. The allowed regions for the Z-Z'$mixing angle are also derived.Comment: 7 pages, Journal versio

Decoherence of Einstein-Podolsky-Rosen pairs in a noisy Andreev entangler

We investigate quantum noise effect on the transportation of nonlocal Cooper pairs accross the realistic Andreev entangler which consists of an s-wave superconductor coupled to two small quantum dots at resonance which themselves are coupled to normal leads. The noise emerges due to voltage fluctuations felt by the electrons residing on the two dots as a result of the finite resistances in the gate leads or of any resistive lead capacitively coupled to the dots. In the ideal noiseless case, the setup provides a trustable source of mobile and nonlocal spin-entangled electrons and the transport is dominated by a two-particle Breit-Wigner resonance that allows the injection of two spin-entangled electrons into different leads at the same energy [P. Recher, E. V. Sukhorukov, and D. Loss, Phys. Rev. B 63, 165314 (2001)]. We seek to revisit the transport of those nonlocal Cooper pairs as well as the efficiency of such an Andreev entangler when including the quantum noise (decoherence).Comment: 15 pages and 6 figures; final version to appear in Physical Review