Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing.

Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can result in ultrastructural muscle disruption, impaired excitation-contraction coupling, inflammation and muscle protein degradation. This process is associated with delayed onset muscle soreness and is referred to as exercise-induced muscle damage. Although a certain amount of muscle damage may be necessary for adaptation to occur, excessive damage or inadequate recovery from exercise-induced muscle damage can increase injury risk, particularly in older individuals, who experience more damage and require longer to recover from muscle damaging exercise than younger adults. Furthermore, it is apparent that inter-individual variation exists in the response to exercise-induced muscle damage, and there is evidence that genetic variability may play a key role. Although this area of research is in its infancy, certain gene variations, or polymorphisms have been associated with exercise-induced muscle damage (i.e. individuals with certain genotypes experience greater muscle damage, and require longer recovery, following strenuous exercise). These polymorphisms include ACTN3 (R577X, rs1815739), TNF (-308 G>A, rs1800629), IL6 (-174 G>C, rs1800795), and IGF2 (ApaI, 17200 G>A, rs680). Knowing how someone is likely to respond to a particular type of exercise could help coaches/practitioners individualise the exercise training of their athletes/patients, thus maximising recovery and adaptation, while reducing overload-associated injury risk. The purpose of this review is to provide a critical analysis of the literature concerning gene polymorphisms associated with exercise-induced muscle damage, both in young and older individuals, and to highlight the potential mechanisms underpinning these associations, thus providing a better understanding of exercise-induced muscle damage

Protocols, performance assessment and consolidation on interfaces for standardization – D3.3

The following document presents a detailed description of the protocol for the “ Control Channels for the Cooperation of the Cognitive Management System ” (C4MS) which provides the necessary means to enable proper management of Opportunistic Networks. Additionally, the document defines the methodology that was applied for the purpose of signalling evaluation. The protocol overview presented in section 2 of the main document, provides the C4MS principles. The section includes, among others, the description of the protocol identifiers, procedures, protocol state machines and message format as well as the security asp ects. Section 3 provides a high-level description of the data structures defined within the scope of OneFIT project. The data structures are classified into five categories, i.e.: Profiles, Context, Decisions,Knowledge and Policies. The high level description is complemented by some detailed data structures in the Appendix to D3.3 Section 3[10]. Section 4 provides details on the evaluation methodology applied for the purpose of C4MS performance assessment. The section presents the evaluation plan along with a description of metrics that are to be exploited in the scope of WP3. Section 5 and Section 6 are composed of the signalling evaluation results. Section 5 focuses on the estimation of the signalling load imposed by ON management in different ON phases. Additionally some results for the initialization phase (not explicitly mentioned in the previous phases of the project)and security related aspects are also depicted. Section 6 on the other hand is focused on the evaluation of the signalling traffic generated by different ON related algorithms. Conclusions to the document are drawn in section 7. Detailed description of the C4MS procedures, implementation options based on IEEE 802.21, DIAMTER and 3GPP are depicted in the appendix to the D3.3[10] . Additionally, the appendix incorporates the detailed definition of the information data structures and final set of Message Sequence Charts (MSCs) provided for the OneFIT project.Peer ReviewedPreprin

Formulation, implementation considerations, and first performance evaluation of algorithmic solutions - D4.1

Deliverable D4.1 del projecte Europeu OneFIT (ICT-2009-257385)This deliverable contains a first version of the algorithmic solutions for enabling opportunistic networks. The presented algorithms cover the full range of identified management tasks: suitability, creation, QoS control, reconfiguration and forced terminations. Preliminary evaluations complement the proposed algorithms. Implementation considerations towards the practicality of the considered algorithms are also included.Preprin

Pharmaceuticals released from senior residences: occurrence and risk evaluation

One of the main pursuits, yet most difficult, in monitoring studies is to identify the sources of environmental pollution. In this study, we have identified health-care facilities from south European countries as an important source of pharmaceuticals in the environment. We have estimated that compounds consumed in by the elderly and released from effluents of senior residences can reach river waters at a concentration higher than 0.01 μg/L, which is the European Medicines Agency (EMA) threshold for risk evaluation of pharmaceuticals in surface waters. This study has been based on five health institutions in Portugal, Spain, and France, with 52 to 130 beds. We have compiled the pharmaceuticals dispensed on a daily base and calculated the consumption rates. From 54.9 to 1801 g of pharmaceuticals are consumed daily, with laxatives, analgesics, antiepileptics, antibiotics, and antidiabetic agents being the main drug families administered. According to excretion rates, dilution in the sewerage system, and elimination in wastewater treatment plants, macrogol, metformin, paracetamol, acetylcysteine, amoxicillin, and gabapentin, among others, are expected to reach river waters. Finally, we discuss the risk management actions related to the discharge of pharmaceuticals from senior residences to surface waters

Proposal of C4MS and inherent technical challenges – D3.1

Deliverable D3.1 del projecte Europeu OneFIT (ICT-2009-257385)The scope of OneFIT is on Opportunistic etworks and Cognitive Management Systems for Efficient Application Provision in the uture Internet. This document contains a proposal of Control Channels for Coordination of Cognitive Management Systems (C4MS) which enables delivery of guidance/assistance information from infrastructure towards the Opportunistic Networks and provides means for the management of Opportunistic Networks. This document defines first messages and elementary procedures for the C4MS as well as it identifies a preliminary set of information which is to be conveyed over C4MS. The document introduces also the inherent technical challenges related to the C4MS proposal.Postprint (published version

Effect of Endocrine Disruptor Pesticides: A Review

Endocrine disrupting chemicals (EDC) are compounds that alter the normal functioning of the endocrine system of both wildlife and humans. A huge number of chemicals have been identified as endocrine disruptors, among them several pesticides. Pesticides are used to kill unwanted organisms in crops, public areas, homes and gardens, and parasites in medicine. Human are exposed to pesticides due to their occupations or through dietary and environmental exposure (water, soil, air). For several years, there have been enquiries about the impact of environmental factors on the occurrence of human pathologies. This paper reviews the current knowledge of the potential impacts of endocrine disruptor pesticides on human health

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Reproductive impacts of tributyltin (TBT) and triphenyltin (TPT) in the hermaphroditic freshwater gastropod Lymnaea stagnalis

Tributyltin (TBT) and triphenyltin (TPT) are emblematic endocrine disruptors, which have been mostly studied in gonochoric prosobranchs. Although both compounds can simultaneously occur in the environment, they have mainly been tested separately for their effects on snail reproduction. Because large discrepancies in experimental conditions occurred in these tests, the present study aimed at comparing the relative toxicity of TBT and TPT under similar laboratory conditions in the 0–600 ng Sn/L range. Tests were performed on the simultaneous hermaphrodite Lymnaea stagnalis, a freshwater snail in which effects of TPT were unknown. Survival, shell length and reproduction were monitored in a 21d semi-static test. Frequency of abnormal eggs was assessed as an additional endpoint. TPT hampered survival while TBT did not. Major effects on shell solidity and reproduction were observed for both compounds, reproductive outputs being more severely hampered by TBT than by TPT. Considering the frequency of abnormal eggs allowed increasing test sensitivity, since snail responses to TBT could be detected at concentrations as low as 19 ng Sn/L. However, the putative mode of action of the two compounds could not be deduced from the structure of the molecules or from the response of apical endpoints. Sensitivity of L. stagnalis to TBT and TPT was compared to the sensitivity of prosobranch molluscs with different habitats and different reproductive strategies

Bilan des connaissances actuelles sur les résidus pharmaceutiques dans l’environnement: résumé du projet KNAPPE

International audienc

Bilan des connaissances actuelles sur les résidus pharmaceutiques dans l’environnement: identification des besoins

National audienc