De linguis orientalibus [Texto impreso] : deque re antiquitatis litteraria theses atque exercitationes

Sign. : []3, A-B4, C

Organizational Culture and Communication Competence Workshop: Masters Plan B

This project began as an attempt to understand how events, such as the “Great Resignation” (i.e., an unprecedented mass exit of employees from the U.S. workforce), have impacted the way in which organizations are attempting to mitigate employee turnover. In addition, this project examined what role managers might play in promoting a positive organizational culture. A review of literature identified Schein’s (1990) model of organizational culture and Spitzberg and Cupach’s (1984) conceptualization of communication competence as useful frameworks for helping managers understand and promote positive organizational culture and employee mental health and well-being. In addition, the review of literature pointed to key skills that could be developed to increase the communication competency of managers. Those skills were identified as, but are not limited to, perception checking, cognitive complexity, empathy, and role-taking. These four skills were the focus of a proposed workshop that is aimed at promoting positive organizational culture and improving managers communication competences

Système RH du sous-traitant et performance de l’échange dans le secteur aéronautique et spatial : le rôle de la qualité de la relation

Ce travail doctoral s’intéresse aux effets du système RH performant d’un sous-traitant sur la performance de l’échange avec le donneur d’ordre. Les théories des ressources et de l’échange social sont mobilisées conjointement afin d’étudier la combinaison complexe entre le système RH performant du sous-traitant, la qualité de la relation entre donneur d’ordre et sous-traitant et la performance de leur échange. Pour tester ce modèle, une étude quantitative multi-sources a été réalisée auprès de cinq grands donneurs d’ordre des secteurs aéronautique et spatial et de leurs principaux sous-traitants. Les résultats issus des analyses de modération montrent que le système RH performant améliore la performance de la relation uniquement lorsque certains aspects de la qualité de la relation avec le donneur d’ordre sont défavorables. En particulier, nos résultats montrent que l’effet du système RH performant est significatif dans trois situations : une justice inter-organisationnelle faible, un pouvoir du donneur d’ordre élevé et une dépendance conjointe faible. Les résultats de cette étude et ses limites sont discutées et des implications managériales à l’intention des donneurs d’ordre et des sous-traitants sont proposées.This doctoral work focuses on the effects of a high performance work system of a supplier on the exchange performance with the buyer. Drawing on resources and social exchange theories, we study the complex combination of a supplier’s high performance work system, buyer-supplier relationship quality and their exchange performance. To test this model, a quantitative multi-source study was conducted with five major buyers in the aeronautical and spatial industry and their main suppliers. Results from interaction analysis indicate that a high performance work system improves relationship performance only when some aspects of the relationship with the buyer are negative. In particular, our results show that the effect of a high performance work system is significant in three situations: low interorganizational justice, high buyer power and low interdependence. These findings and their limitations are discussed and managerial implications for buyers and suppliers are proposed

Système RH du sous-traitant et performance de l’échange dans le secteur aéronautique et spatial : le rôle de la qualité de la relation

Ce travail doctoral s’intéresse aux effets du système RH performant d’un sous-traitant sur la performance de l’échange avec le donneur d’ordre. Les théories des ressources et de l’échange social sont mobilisées conjointement afin d’étudier la combinaison complexe entre le système RH performant du sous-traitant, la qualité de la relation entre donneur d’ordre et sous-traitant et la performance de leur échange. Pour tester ce modèle, une étude quantitative multi-sources a été réalisée auprès de cinq grands donneurs d’ordre des secteurs aéronautique et spatial et de leurs principaux sous-traitants. Les résultats issus des analyses de modération montrent que le système RH performant améliore la performance de la relation uniquement lorsque certains aspects de la qualité de la relation avec le donneur d’ordre sont défavorables. En particulier, nos résultats montrent que l’effet du système RH performant est significatif dans trois situations : une justice inter-organisationnelle faible, un pouvoir du donneur d’ordre élevé et une dépendance conjointe faible. Les résultats de cette étude et ses limites sont discutées et des implications managériales à l’intention des donneurs d’ordre et des sous-traitants sont proposées.This doctoral work focuses on the effects of a high performance work system of a supplier on the exchange performance with the buyer. Drawing on resources and social exchange theories, we study the complex combination of a supplier’s high performance work system, buyer-supplier relationship quality and their exchange performance. To test this model, a quantitative multi-source study was conducted with five major buyers in the aeronautical and spatial industry and their main suppliers. Results from interaction analysis indicate that a high performance work system improves relationship performance only when some aspects of the relationship with the buyer are negative. In particular, our results show that the effect of a high performance work system is significant in three situations: low interorganizational justice, high buyer power and low interdependence. These findings and their limitations are discussed and managerial implications for buyers and suppliers are proposed

Imagen del SS.mo Cristo de la Agonía [ [Material gráfico]: venerada por su M.I. Cofradía y Hermandad en su capilla del Hospital Genl. de Valencia

Copia digital. España : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, d2024La Litografía V. Alegre tiene su sede en Valencia.Antonio Bergon ejerció en la segunda mitad del s. XIX.Registro de la Propiedad Intelectual, Ley de 1847: 9018; n. de solicitud de ingreso: "3064"; fecha y datos del ingreso: "Mayo 9/64

Performance of a Quantitative PCR-Based Assay and Beta-d-Glucan Detection for Diagnosis of Invasive Candidiasis in Very-Low-Birth-Weight Preterm Neonatal Patients (CANDINEO Study)

An epidemiological, multicenter, noninterventional, observational case-control study was conducted to describe the performance of serum beta-d-glucan (BDG) and Candida PCR in blood, serum, and sterile samples for the diagnosis of invasive candidiasis (IC) in very-low-birth-weight (VLBW) preterm neonates and to compare these techniques with culture of samples from blood and other sterile sites. Seventeen centers participated in the study, and the number of episodes analyzed was 159. A total of 9 episodes of IC from 9 patients (7 confirmed and 2 probable) and 150 episodes of suspected sepsis from 117 controls were identified. The prevalence of IC was 5.7% (95% confidence interval [95% CI], 2.1 to 9.3). The mortality was significantly higher in episodes of IC (44.4%) than in the non-IC episodes (11.1%, P < 0.01). The sensitivity and specificity of the PCR performed on blood/serum samples were 87.5% and 81.6%, respectively. The sensitivity and specificity of the BDG results were lower (75.0% and 64.6%). For cases with negative culture results, the PCR and the BDG results were positive in 27 (17.4%) and 52 (33.5%) episodes, respectively. The presence of multiorgan failure, improvement with empirical antifungal therapy, thrombocytopenia, and Candida colonization were significantly associated (P < 0.01) with PCR or BDG positivity regardless of the results of the cultures. Serum BDG analysis and Candida PCR could be used as complementary diagnostic techniques to detect IC in VLBW neonates.This study was initiated and financially supported by Astellas Pharma Inc. Manuel Cuenca-Estrella has received grant support from Astellas Pharma Inc., bioMérieux, Basilea, Gilead Sciences, Merck Sharp & Dohme, Pfizer, Schering Plough, Soria Melguizo SA, Ferrer International, the European Union, the ALBAN program, the Spanish Agency for International Cooperation, the Spanish Ministry of Culture and Education, the Spanish Health Research Fund, Instituto de Salud Carlos III (Spanish Ministry of Economy and Competitiveness), the Ramon Areces Foundation, and the Mutua Madrileña Foundation. Jose T. Ramos has received fees for conferences from Gilead Sciences, ViiV Healthcare, and Janssen-Cilag and grant support from the Gilead Fellowship Program. Elena Bergon-Sendin received grant support from Astellas Pharma Inc. during the conduct of the study. Paloma Anguita Alonso is an employee of Astellas Pharma Inc. The rest of us have no conflicts to report. Medical writing support was provided by Lucy Kanan on behalf of Bioscript Medical Ltd., funded by Astellas Pharma IncS

Lasers as a Bridge between Atomic and Nuclear Physics

This paper reviews the application of optical and UV laser radiation to several topics in low-energy nuclear physics. We consider the laser-induced nuclear anti-Stokes transitions, the laser-assisted and the laser-induced internal conversion, and the Electron Bridge and Inverse Electron Bridge mechanisms as tools for deexciting and exciting of low-lying nuclear isomeric states. A study of the anomalous, by low-lying, nuclear isomeric states (on an example of the $^{229}$Th nucleus) is presented in detail.Comment: 67 pages, Tex, 18 figures available upon request from [email protected]

TranscriptomeBrowser: A Powerful and Flexible Toolbox to Explore Productively the Transcriptional Landscape of the Gene Expression Omnibus Database

International audienceAs public microarray repositories are constantly growing, we are facing the challenge of designing strategies to provide productive access to the available data.\ We used a modified version of the Markov clustering algorithm to systematically extract clusters of co-regulated genes from hundreds of microarray datasets stored in the Gene Expression Omnibus database (n = 1,484). This approach led to the definition of 18,250 transcriptional signatures (TS) that were tested for functional enrichment using the DAVID knowledgebase. Over-representation of functional terms was found in a large proportion of these TS (84%). We developed a JAVA application, TBrowser that comes with an open plug-in architecture and whose interface implements a highly sophisticated search engine supporting several Boolean operators (http://tagc.univ-mrs.fr/tbrowser/). User can search and analyze TS containing a list of identifiers (gene symbols or AffyIDs) or associated with a set of functional terms.\ As proof of principle, TBrowser was used to define breast cancer cell specific genes and to detect chromosomal abnormalities in tumors. Finally, taking advantage of our large collection of transcriptional signatures, we constructed a comprehensive map that summarizes gene-gene co-regulations observed through all the experiments performed on HGU133A Affymetrix platform. We provide evidences that this map can extend our knowledge of cellular signaling pathways

Literature and Environment, the Long View: Thoughts from the Founders of ASLE

The Association for the Study of Literature and Environment (ASLE) is the primary professional organization of scholars, teachers, and writers who study the relationships among literature, culture, and the physical environment. At a recent roundtable discussion at the Western American Literature Association's Annual Conference, "flash papers" from ASLE's founders offered a fascinating array of view points reflecting on ASLE's twenty year history. Papers look at wilderness, post naturalism, science fiction, pedagogy, publishing and climate change. It is our hope that the set of papers collected here will commemorate a historical moment and spark a continuing conversation on the future of the organization

Olfactory Stem Cells, a New Cellular Model for Studying Molecular Mechanisms Underlying Familial Dysautonomia

International audienceBackground: Familial dysautonomia (FD) is a hereditary neuropathy caused by mutations in the IKBKAP gene, the most common of which results in variable tissue-specific mRNA splicing with skipping of exon 20. Defective splicing is especially severe in nervous tissue, leading to incomplete development and progressive degeneration of sensory and autonomic neurons. The specificity of neuron loss in FD is poorly understood due to the lack of an appropriate model system. To better understand and modelize the molecular mechanisms of IKBKAP mRNA splicing, we collected human olfactory ecto-mesenchymal stem cells (hOE-MSC) from FD patients. hOE-MSCs have a pluripotent ability to differentiate into various cell lineages, including neurons and glial cells.Methodology/Principal Findings: We confirmed IKBKAP mRNA alternative splicing in FD hOE-MSCs and identified 2 novel spliced isoforms also present in control cells. We observed a significant lower expression of both IKBKAP transcript and IKAP/hELP1 protein in FD cells resulting from the degradation of the transcript isoform skipping exon 20. We localized IKAP/hELP1 in different cell compartments, including the nucleus, which supports multiple roles for that protein. We also investigated cellular pathways altered in FD, at the genome-wide level, and confirmed that cell migration and cytoskeleton reorganization were among the processes altered in FD. Indeed, FD hOE-MSCs exhibit impaired migration compared to control cells. Moreover, we showed that kinetin improved exon 20 inclusion and restores a normal level of IKAP/hELP1 in FD hOE-MSCs. Furthermore, we were able to modify the IKBKAP splicing ratio in FD hOE-MSCs, increasing or reducing the WT (exon 20 inclusion):MU (exon 20 skipping) ratio respectively, either by producing free-floating spheres, or by inducing cells into neural differentiation.Conclusions/Significance: hOE-MSCs isolated from FD patients represent a new approach for modeling FD to better understand genetic expression and possible therapeutic approaches. This model could also be applied to other neurological genetic diseases