The Market Place of Political Opinions:: Public Opinion Polling and its Publics in Transnational Perspective, 1930–1950

Der Markt der politischen Meinungen. Meinungsforschung und ihre Öffentlichkeiten in transnationaler Perspektive, 1930–1950 Dieser Artikel analysiert die wirtschaftliche und mediale Dynamik, die der Einführung und schnellen Verbreitung der repräsentativen Meinungsforschung zwischen 1930 und 1950 zugrunde lag. Der Artikel bringt dabei verschiedene Forschungsansätze der letzten Jahre zusammen. Er verbindet den Prozess der Medialisierung mit den Kategorien von „Aufmerksamkeit“ und „Vertrauen“ um aufzuzeigen, wie Zeitgenossen zunächst mit dieser neuen Wissenstechnik vertraut wurden, und warum sie der neuartigen Darstellung von „öffentlicher Meinung“ Glauben schenkten. Dabei betont er insbesondere die transnationale Situierung des Einführungsprozesses, die in der bestehenden Literatur bislang nur am Rande behandelt wird. Tatsächlich ist die schnelle Verbreitung der repräsentativen Meinungsforschung nicht nur eine gemeinsame Erfahrung von Demokratien seit den dreißiger Jahren des 20. Jahrhunderts, sondern ein genuin transnationaler Prozess, der auf dem Austausch von Ideen, Praktiken und Personal beruht und der beeinflusst wurde von Beobachtungen der Entwicklungen in anderen Ländern

The transition to adulthood in China, Germany and the US: Prevalence and timing in private and professional life

We explore cross-country differences in the transition to adulthood between China, Germany, and the USA. Using large-scale panel studies, we examine the timing of leaving the parental home, first marriage and first parenthood. For those born between 1933 and 1988, we observe a delay in the timing of first marriage in all three societies. But the delay is steeper in the USA than in Germany and China. The age at first childbirth is increasing in all three countries. By age 30, most individuals in China have married their first partner and become parents, whereas in the USA and Germany less than half of the population have experienced one of these events. There are large differences in educational and employment trajectories between the urban and rural populations in China, less so in the USA, whereas almost no differences are observed in Germany. The three countries are alike in the proportion of individuals who have left the parental home by age 30. In all three countries, individuals without tertiary qualifications are more likely to have experienced all three events by age 30. But with regard to first marriage, a larger share of higher-educated individuals get married by the age of 30 in the USA, whereas in China it is the less educated who are more likely to get married

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

TRAIL Receptor Signaling Regulation of Chemosensitivity In Vivo but Not In Vitro

Background: Signaling by Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) and Fas ligand (FasL) has been proposed to contribute to the chemosensitivity of tumor cells treated with various other anti-cancer agents. However, the importance of these effects and whether there are differences in vitro and in vivo is unclear. Methodology/Principal Findings: To assess the relative contribution of death receptor pathways to this sensitivity and to determine whether these effects are intrinsic to the tumor cells, we compared the chemosensitivity of isogenic BJAB human lymphoma cells where Fas and TRAIL receptors or just TRAIL receptors were inhibited using mutants of the adaptor protein FADD or by altering the expression of the homeobox transcription factor Six1. Inhibition of TRAIL receptors did not affect in vitro tumor cell killing by various anti-cancer agents indicating that chemosensitivity is not significantly affected by the tumor cell-intrinsic activation of death receptor signaling. However, selective inhibition of TRAIL receptor signaling caused reduced tumor regression and clearance in vivo when tested in a NOD/SCID mouse model. Conclusions: These data show that TRAIL receptor signaling in tumor cells can determine chemosensitivity in vivo but not in vitro and thus imply that TRAIL resistance makes tumors less susceptible to conventional cytotoxic anti-cancer drugs a

Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma

Although both Mcl-1 and Bcl-xL keep proapoptotic Bak in check, it is the loss of Mcl-1 that sensitizes cells to death receptor–mediated apoptosis

Multimessenger search for sources of gravitational waves and high-energy neutrinos: Initial results for LIGO-Virgo and IceCube

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