A Comparison of Plasma Methylprednisolone Concentrations Following Intra-Articular Injection in Patients with Rheumatoid Arthritis and Osteoarthritis

Plasma concentrations of methylprednislone following intra-articular injection were measured in rheumatoid arthritis and osteoarthritis patients. While substantial plasma concentrations were seen in both groups of patients, there was so significant difference in the rate or extent of absorption from osteoarthritic or rheumatoid knees. This study suggests that it is the dissolution rate of the steroid formulation rather than the characteristics of the synovial membrane which determine rate and extent of systemic absorption of methylprednislone after intra-articular injection

Sonatas a 3

Georg von Bertouch (1668–1743) was a German-born musician and military officer who spent a considerable part of his adult life in Norway. He composed a cycle of twenty-four sonatas in each of the twenty-four keys, of which only eighteen survive in a fragmentary Scandinavian eighteenth-century manuscript that originally included the entire set. Two sonatas, one of which is written in C-sharp major, are scored for trumpet, two violins, and continuo; they feature virtuosic writing for the trumpet. The remaining sonatas were probably all scored for two violins and continuo. Bertouch, who in his youth had made the acquaintance of the Bach family, seems to have sent a copy of the sonatas to J. S. Bach, and Bertouch's cycle of sonatas is an interesting analogue to Bach's Well-Tempered Clavier. The edition will be of interest not only to Bach scholars and performers, but also to those studying eighteenth-century key characteristics and baroque tuning systems.</jats:p

Vor vierzig Jahren. Natur und Cultur auf der nordfriesischen Insel Nordstrand,

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