Energy levels and transition matrix elements of paramagnetic crystals for maser applications

Univac computer programs for energy levels and transition probabilities for ruby and emerald

Paramagnetic energy levels of the ground state of Cr/+3/ in Al2O3

Paramagnetic energy levels of ground state of chromium 3 and aluminum oxide

Low-noise K(u)-band receiver input system

Improved maser and superconducting magnet, which operates in vacuum of closed-cycle helium refrigerator, comprise a low-noise, reliable, field-operational receiver input system

Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection?

Indexación: Web of Science.Background: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. cruzi Calreticulin (TcCRT), an endoplasmic reticulum-resident chaperone, translocated-externalized by the parasite, may mediate at least an important part of this effect. Thus, recombinant TcCRT (rTcCRT) has important in vivo antiangiogenic and antitumor activities. However, the relevant question whether the in vivo antitumor effect of T. cruzi infection is indeed mediated by the native chaperone (nTcCRT), remains open. Herein, by using specific modified anti-rTcCRT antibodies (Abs), we have neutralized the antitumor activity of T. cruzi infection and extracts thereof, thus identifying nTcCRT as a valid mediator of this effect. Methods: Polyclonal anti-rTcCRT F(ab')(2) Ab fragments were used to reverse the capacity of rTcCRT to inhibit EAhy926 endothelial cell (EC) proliferation, as detected by BrdU uptake. Using these F(ab')(2) fragments, we also challenged the capacity of nTcCRT, during T. cruzi infection, to inhibit the growth of an aggressive mammary adenocarcinoma cell line (TA3-MTXR) in mice. Moreover, we determined the capacity of anti-rTcCRT Abs to reverse the antitumor effect of an epimastigote extract (EE). Finally, the effects of these treatments on tumor histology were evaluated. Results: The rTcCRT capacity to inhibit ECs proliferation was reversed by anti-rTcCRT F(ab')(2) Ab fragments, thus defining them as valid probes to interfere in vivo with this important TcCRT function. Consequently, during infection, these Ab fragments also reversed the in vivo experimental mammary tumor growth. Moreover, anti-rTcCRT Abs also neutralized the antitumor effect of an EE, again identifying the chaperone protein as an important mediator of this anti mammary tumor effect. Finally, as determined by conventional histological parameters, in infected animals and in those treated with EE, less invasive tumors were observed while, as expected, treatment with F(ab')(2) Ab fragments increased malignancy. Conclusion: We have identified translocated/externalized nTcCRT as responsible for at least an important part of the anti mammary tumor effect of the chaperone observed during experimental infections with T. cruzi.http://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2764-

ANALISIS KELEMBAGAAN PENGEMBANGAN HUTAN ADAT DESA TORO KECAMATAN KULAWI KABUPATEN SIGI PROVINSI SULAWESI TENGAH

This research aimed to revitalizethe local institution and its implication on the management of natural resources in Lore Lindu National Park area. The research was conducted at the village of Toro, Kulawi district, Sigi Regency, Central Sulawesi, from October through December 2013. The method used in this study is the method of historical and institutional analysis and qualitative approach by interview process on key informants as respondents.The results showed that institutional revitalization was influenced by community needs on institution development caused social dynamics and community economy. New institutional revitalization has implication on structure and regulation change of local institution of Toro village. Institution in Toro was contributed by local leadership role particularly in determination of natural resources and social economy. Keywords: Institution Analysis, Development, Community Forest, Toro Community

Penguatan Pemahaman Visi Sosio-Eco-Techno-Preneurship pada Pembentukan Karakter Mahasiswa IAIN Metro

 Lembaga pendidikan dituntut untuk memiliki berbagai kemampuan baik yang berkaitan dengan masalah manajemen maupun kualitas pendidikannya agar dapat terus berkembang sesui dengan perkembangan zaman. Tujuan dari kegiatan penguatan pemahaman visi IAIN Metro “socio – eco – techno – preneurship” dalam pembentukan mahasiswa IAIN Metro adalah dapat memfasilitasi mahasiswa dengan pemahaman konsep yang menghasilkan capaian kemampuan yang matang mengenai visi IAIN Metro. Pelaksanaan pengabdian kepada masyarakat ini dilakukan melalui pendampingan melalui pengabdian participatory action research (PAR). Kegiatan pendampingan penguatan pemahamahan visi “socio – eco – techno – preneurship” dalam pembentukan karakter mahasiswa IAIN Metro di Fakultas Ekonomi dan Bisnis Islam (FEBI) IAIN Metro membuat mahasiswa dapat mengimplementasikan dalam kehidupan sehari – hari baik di lingkungan kampus maupun masyarakat

Atlantic Equatorial Undercurrent and associated cold tongue variability

The Atlantic Equatorial Undercurrent (EUC) is studied using a simulation for the period 1990–2002 with a high-resolution ocean general circulation model. Simulated transports of the EUC that supplies the annual mean upwelling in the central and eastern equatorial Atlantic are in good agreement with new transport estimates derived from ship observations, i.e., 19.9 and 14.0 Sv at 35°W and 23°W, respectively. Although the observations are not conclusive concerning the seasonal cycle of EUC transports, the simulated seasonal cycles fit largely in the observed range. The analysis of the EUC variability associated with interannual boreal summer variability of the equatorial cold tongue showed that cold tongue indices, defined either by near-surface temperature or steric height anomalies, are anticorrelated with thermocline EUC transport anomalies: A strong EUC corresponds to low near-surface temperatures and steric heights. The importance of equatorial waves for the cold tongue region is shown: Surface layer transport anomalies at 23°W and 10°W are significantly correlated with both near-surface temperature and steric height anomalies in the equatorial and coastal upwelling regions, indicating an associated eastward phase propagation along the equator toward the African coast where the signal bifurcates into two poleward branches along the coast and is reflected into a westward propagating wave

IL-10 Immunomodulation of Myeloid Cells Regulates a Murine Model of Ovarian Cancer

Elevated levels of IL-10 in the microenvironment of human ovarian cancer and murine models of ovarian cancer are well established and correlate with poor clinical prognosis. However, amongst a myriad of immunosuppressive factors, the actual contribution of IL-10 to the ovarian tumor microenvironment, the mechanisms by which it acts, and its possible functional redundancy are unknown. We previously demonstrated that elimination of the myeloid-derived suppressor cell (MDSC) compartment within the ovarian tumor ascites inhibited tumor progression and, intriguingly, significantly decreased local IL-10 levels. Here we identify a novel pathway in which the tumor-infiltrating MDSC are the predominant producers of IL-10 and, importantly, require it to develop their immunosuppressive function in vivo. Importantly, we demonstrate that the role of IL-10 is critical, and not redundant with other immunosuppressive molecules, to in vivo tumor progression: blockade of the IL-10 signaling network results in alleviation of MDSC-mediated immunosuppression, altered T cell phenotype and activity, and improved survival. These studies define IL-10 as a fundamental modulator of both MDSC and T cells within the ovarian tumor microenvironment. Importantly, IL-10 signaling is shown to be necessary to the development and maintenance of a permissive tumor microenvironment and represents a viable target for anti-tumor strategies